Patents by Inventor Arthur M. Krieg

Arthur M. Krieg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040162258
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: January 30, 2004
    Publication date: August 19, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmacuetical Group, Inc., The USA as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040152656
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: February 26, 2004
    Publication date: August 5, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmacuetical Group, Inc., The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040152657
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: February 26, 2004
    Publication date: August 5, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040152649
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Application
    Filed: July 3, 2003
    Publication date: August 5, 2004
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20040147468
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: October 3, 2003
    Publication date: July 29, 2004
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040143112
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: October 21, 2003
    Publication date: July 22, 2004
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040142469
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: February 26, 2004
    Publication date: July 22, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmacuetical Group, Inc., The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040132685
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: December 22, 2003
    Publication date: July 8, 2004
    Applicant: The University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel Kline
  • Publication number: 20040106568
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Application
    Filed: July 25, 2003
    Publication date: June 3, 2004
    Applicants: University of Iowa Research Foundation, The United States of America, as Represented by the Secretary, Dept. of Health & Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040092472
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Application
    Filed: July 3, 2003
    Publication date: May 13, 2004
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20040087538
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Application
    Filed: November 21, 2003
    Publication date: May 6, 2004
    Applicant: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, George Weiner
  • Publication number: 20040087534
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: July 30, 2003
    Publication date: May 6, 2004
    Applicants: University of Iowa Research Foundation, The United States of America, as Represented by the Secretary, Dept. of Health and Human Services, Coley Pharmaceutical Group, Inc., CPG Immunopharmaceuticals, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040067905
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Application
    Filed: July 3, 2003
    Publication date: April 8, 2004
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20040053880
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Application
    Filed: July 3, 2003
    Publication date: March 18, 2004
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20040009949
    Abstract: Improved methods are provided for inhibiting nucleic acid-induced immune activation and for treating autoimmune disease. The methods involve using an inhibitory nucleic acid in synergistic combination with a small molecule antagonist of immunostimulatory CpG nucleic acids. Inhibitory nucleic acids useful according to the invention include poly G nucleic acids. Small molecule antagonists of immunostimulatory CpG nucleic acids useful according to the invention include chloroquine and derivatives of chloroquine-like molecules, including substituted 2-phenylquinolin-4-amines.
    Type: Application
    Filed: June 5, 2003
    Publication date: January 15, 2004
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20030224010
    Abstract: The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 4, 2003
    Applicants: Coley Pharmaceutical GmbH, University of Iowa Research Foundation, CPG Immunopharmaceuticals GMBH, Ottawa Health Research Institute
    Inventors: Heather L. Davis, Joachim Schorr, Arthur M. Krieg
  • Patent number: 6653292
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: November 25, 2003
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, George Weiher
  • Publication number: 20030212026
    Abstract: The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
    Type: Application
    Filed: December 9, 2002
    Publication date: November 13, 2003
    Applicant: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Christian Schetter, Jorg Vollmer
  • Publication number: 20030191079
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Application
    Filed: November 27, 2002
    Publication date: October 9, 2003
    Applicant: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20030148976
    Abstract: A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an immune response and is useful for treating a variety of immune realted disorders such as cancer, infectious disease, and allergic disorders. The nucleic acids also stimulate activation of natural killer cells and production of type 1 interferon.
    Type: Application
    Filed: August 19, 2002
    Publication date: August 7, 2003
    Inventors: Arthur M. Krieg, Jorg Vollmer