Patents by Inventor Arun K. Ghosh

Arun K. Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20240124395
    Abstract: Inhibitors of SARS-COV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: October 23, 2023
    Publication date: April 18, 2024
    Inventors: Arun K. Ghosh, Monika Yadav, Andrew Mesecar
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20240116865
    Abstract: Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: November 8, 2023
    Publication date: April 11, 2024
    Inventors: Arun K. Ghosh, Monika Yadav, Andrew Mesecar
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20240101541
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID) and methods of using them to treat a severe acute respiratory syndrome.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 28, 2024
    Applicant: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Andrew Mesecar, Hiroaki Mitsuya
  • METHODS FOR MAKING DARUNAVIR P2-LIGAND PRECURSORS
    Publication number: 20240043438
    Abstract: A method for making an optically active P2-ligand precursor comprising converting D-xylose or a derivative thereof or D-glucose or a derivative thereof to the optically active P2-ligand precursor.
    Type: Application
    Filed: June 11, 2021
    Publication date: February 8, 2024
    Inventors: Arun K. Ghosh, William Lewis Robinson, Shivaji Markad
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20240043417
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID) and methods of using them to treat a severe acute respiratory syndrome.
    Type: Application
    Filed: November 30, 2021
    Publication date: February 8, 2024
    Applicant: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Andrew Mesecar
  • Anti-cancer agents and preparation thereof
    Patent number: 11851441
    Abstract: Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: December 26, 2023
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-b]PYRAN-8-OL
    Publication number: 20230399338
    Abstract: The disclosure relates to a method of synthesizing the high-affinity, non-petidyl ligand (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-ol, which is useful in the synthesis of various compounds, such as HIV-1 protease inhibitors.
    Type: Application
    Filed: April 10, 2023
    Publication date: December 14, 2023
    Inventors: Arun K. Ghosh, Shivaji Markad
  • Compounds for the treatment of SARS
    Patent number: 11834408
    Abstract: Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: December 5, 2023
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Monika Yadav, Andrew Mesecar
  • Herboxidiene derivatives and uses thereof
    Patent number: 11807631
    Abstract: Described herein are compounds of the formulae (I)-(III) and (Ia)-(IIIa) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods using compounds of the formulae (I)-(III) and (Ia)-(IIIa) to, among other things, treat cancer.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 7, 2023
    Assignees: Purdue Research Foundation, The Regents of the University of California
    Inventors: Arun K. Ghosh, Melissa Jurica
  • Compounds for the treatment of SARS
    Patent number: 11795159
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: October 24, 2023
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Andrew Mesecar, Dana Shahabi
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20230192671
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: March 15, 2021
    Publication date: June 22, 2023
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Andrew Mesecar
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20230183207
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: February 9, 2021
    Publication date: June 15, 2023
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20230159516
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: February 23, 2021
    Publication date: May 25, 2023
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Monika Yadav, Andrew Mesecar
  • TRICYCLIC P2-LIGAND CONTAINING POTENT HIV-PROTEASE INHIBITORS
    Publication number: 20230136594
    Abstract: Compounds of formula (I), pharmaceutical compositions comprising compounds of the formula (I), and methods of treating an HIV infection comprising administering an effective amount of one or more compounds of formula (I), or a pharmaceutical composition comprising same.
    Type: Application
    Filed: January 18, 2021
    Publication date: May 4, 2023
    Inventors: Hiroaki Mitsuya, Arun K. Ghosh, Satish Kovela
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20220411401
    Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: May 23, 2022
    Publication date: December 29, 2022
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Andrew Mesecar, Dana Shahabi
  • COMPOUNDS FOR THE TREATMENT OF SARS
    Publication number: 20220396550
    Abstract: Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
    Type: Application
    Filed: May 26, 2022
    Publication date: December 15, 2022
    Inventors: Arun K. Ghosh, Monika Yadav, Andrew Mesecar
  • BACE1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20220389030
    Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.
    Type: Application
    Filed: January 3, 2022
    Publication date: December 8, 2022
    Inventors: Arun K. Ghosh, Andrew Mesecar, Margherita Brindisi, Emilio Leal Cardenas
  • HIV-1 PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20220363688
    Abstract: Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof. The compounds disclosed herein are as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection.
    Type: Application
    Filed: January 15, 2020
    Publication date: November 17, 2022
    Inventors: Arun K. Ghosh, Satish Kovela, Hiroaki Mitsuya
  • Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS
    Patent number: 11390630
    Abstract: Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: July 19, 2022
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Prasanth Reddy Nyalapatla
  • Macrocyclic HIV-1 protease inhibitors and uses thereof
    Patent number: 11230550
    Abstract: Described herein are compounds of the formulae (I), (Ia), (Ib), and (II) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods of making and using compounds of the formulae (I), (Ia), (Ib), and (II) to, among other things, treat HIV/AIDS.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: January 25, 2022
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Sean Fyvie, Margherita Brindisi