Patents by Inventor Arun K. Ghosh

Arun K. Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BACE1 inhibitors for the treatment of Alzheimer's disease
    Patent number: 11214579
    Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: January 4, 2022
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Andrew Mesecar, Margherita Brindisi, Emilio Leal Cardenas
  • ANTI-CANCER AGENTS AND PREPARATION THEREOF
    Publication number: 20210395265
    Abstract: Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.
    Type: Application
    Filed: November 9, 2020
    Publication date: December 23, 2021
    Inventor: Arun K. Ghosh
  • TRICYCLIC P2-LIGAND CONTAINING POTENT HIV-PROTEASE INHIBITORS AGAINST HIV/AIDS
    Publication number: 20210261563
    Abstract: Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 am defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.
    Type: Application
    Filed: May 4, 2021
    Publication date: August 26, 2021
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Prasanth Reddy Nyalapatla
  • Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS
    Patent number: 11028096
    Abstract: Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: June 8, 2021
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Prasanth Reddy Nyalapatla
  • Callyspongiolide, analogs thereof and uses thereof
    Patent number: 10875836
    Abstract: Described herein are compounds of the formula (I)-(III) (or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof), as well as methods of making and using compounds of the formula (I)-(III) to, among other things, treat various forms of cancer.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: December 29, 2020
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Luke A. Kassekert
  • Anti-cancer agents and preparation thereof
    Patent number: 10858371
    Abstract: Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: December 8, 2020
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • BACE1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20200299308
    Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.
    Type: Application
    Filed: October 12, 2018
    Publication date: September 24, 2020
    Inventors: Arun K. Ghosh, Andrew Mesecar, Margherita Brindisi, Emilio Leal Cardenas
  • HERBOXIDIENE DERIVATIVES AND USES THEREOF
    Publication number: 20200207746
    Abstract: Described herein are compounds of the formulae (I)-(III) and (Ia)-(IIIa) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods using compounds of the formulae (I)-(III) and (Ia)-(IIIa) to, among other things, treat cancer.
    Type: Application
    Filed: July 26, 2018
    Publication date: July 2, 2020
    Inventors: Arun K. Ghosh, Melissa Jurica
  • MACROCYCLIC HIV-1 PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20200165264
    Abstract: Described herein are compounds of the formulae (I), (Ia), (Ib), and (II) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods of making and using compounds of the formulae (I), (Ia), (Ib), and (II) to, among other things, treat HIV/AIDS.
    Type: Application
    Filed: June 29, 2018
    Publication date: May 28, 2020
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Sean Fyvie, Margherita Brindisi
  • TRICYCLIC P2-LIGAND CONTAINING POTENT HIV-PROTEASE INHIBITORS AGAINST HIV/AIDS
    Publication number: 20190359626
    Abstract: Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.
    Type: Application
    Filed: November 9, 2017
    Publication date: November 28, 2019
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Prasanth Reddy Nyalapatla
  • HIV-1 protease inhibitors and uses thereof
    Patent number: 10472372
    Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1—R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: November 12, 2019
    Assignees: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya
  • CALLYSPONGIOLIDE, ANALOGS THEREOF AND USES THEREOF
    Publication number: 20190218198
    Abstract: Described herein are compounds of the formula (I)-(III) (or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof), as well as methods of making and using compounds of the formula (I)-(III) to, among other things, treat various forms of cancer.
    Type: Application
    Filed: May 26, 2017
    Publication date: July 18, 2019
    Inventors: Arun K. Ghosh, Luke A. Kassekert
  • ANTI-CANCER AGENTS AND PREPARATION THEREOF
    Publication number: 20190218228
    Abstract: Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.
    Type: Application
    Filed: September 22, 2017
    Publication date: July 18, 2019
    Inventor: Arun K. Ghosh
  • HIV-1 PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20180244688
    Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1-R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 30, 2018
    Applicants: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya
  • Anti-cancer agents and preparation thereof
    Patent number: 10000505
    Abstract: Embodiments of the present invention provide, among other compounds, a family of spliceosome-inhibiting compounds that can be used as therapeutic anti-cancer agents. The compounds are synthesized in a process that includes the catalytic cross metathesis of a cyclic epoxy alcohol to an amide.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: June 19, 2018
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • Methods and compositions for treating HIV infections
    Patent number: 9808527
    Abstract: Described herein are compounds and compositions that are useful in the treatment of HIV, AIDS, and AIDS-related diseases. In addition, compounds are described herein that are capable of inhibiting the dimerization of HIV proteases.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: November 7, 2017
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Yasuhiro Koh
  • HIV-1 protease inhibitors and uses thereof
    Patent number: 9670225
    Abstract: Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein X1, X2, X3, R1, R2, R11, and n are defined herein. These compounds are useful as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: June 6, 2017
    Assignees: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Venkateswara Rao Kalapala, Hiroaki Mitsuya
  • Compounds and methods for treating AIDS and HIV infections
    Patent number: 9617276
    Abstract: Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: April 11, 2017
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • HIV-1 PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20170088555
    Abstract: Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein X1, X2, X3, R1, R2, R11, and n are defined herein. These compounds are useful as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection.
    Type: Application
    Filed: May 15, 2015
    Publication date: March 30, 2017
    Inventors: Arun K. Ghosh, Venkateswara Kalapala Rao, Hiroaki Mitsuya
  • Compounds for inhibition of memapsin 1
    Patent number: 9512099
    Abstract: Various embodiments of the present invention relate to, among other things, compounds that are inhibitors of Memapsin 1 and, as a result, are effective in the treatment of Alzheimer's disease or diabetes (e.g., Type 2 diabetes).
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: December 6, 2016
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh