Patents by Inventor Arun K. Ghosh

Arun K. Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating HIV
    Patent number: 9499558
    Abstract: Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: November 22, 2016
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Bruno D. Chapsal, Hiroaki Mitsuya, Cuthbert D Martyr
  • Fused tricyclic ether carbamates and their use
    Patent number: 9487541
    Abstract: Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: November 8, 2016
    Assignees: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Chun-Xiao Xu, Hiroaki Mitsuya, Garth Parham
  • ANTI-CANCER AGENTS AND PREPARATION THEREOF
    Publication number: 20160297831
    Abstract: Embodiments of the present invention provide, among other compounds, a family of spliceosome-inhibiting compounds that can be used as therapeutic anti-cancer agents. The compounds are synthesized in a process that includes the catalytic cross metathesis of a cyclic epoxy alcohol to an amide.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 13, 2016
    Inventor: Arun K. Ghosh
  • Small molecule inhibitors of HIV proteases
    Patent number: 9359317
    Abstract: Described herein are compounds, compositions, and methods for treating HIV and related diseases.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: June 7, 2016
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • HIV-1 protease inhibitors having gem-di-fluoro bicyclic P2-ligands
    Patent number: 9346820
    Abstract: Various embodiments of the present invention relate to, among other things, compounds and methods of using those compounds to treat an HIV infection. The compounds of the various embodiments of the present invention provide, among other things, therapeutic agents having enhanced penetration capability across the blood-brain barrier, such that they can enter the CNS to treat an HIV-1 infection in the CNS.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: May 24, 2016
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Sofiya Yashchuk
  • C-3 substituted bicyclooctane based HIV protease inhibitors
    Patent number: 9309213
    Abstract: C3-functionalized-cyclopentanyltetrahydrofuranyl carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are described. Compositions comprising the disclosed compound and methods of using the compounds and/or compositions for treating patients infected with HIV are also described.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: April 12, 2016
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Bruno D. Chapsal
  • COMPOUNDS AND METHODS FOR TREATING HIV
    Publication number: 20150225414
    Abstract: Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described.
    Type: Application
    Filed: April 21, 2015
    Publication date: August 13, 2015
    Inventors: Arun K. Ghosh, Bruno D. Chapsal, Hiroaki Mitsuya, Cuthbert D. Martyr
  • Inhibition of memapsin 1 cleavage in the treatment of diabetes
    Patent number: 9096541
    Abstract: Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in the treatment of disease.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: August 4, 2015
    Assignees: Oklahoma Medical Research Foundation, Purdue Research Foundation
    Inventors: Jordan Tang, Xiangping Huang, Deborah Downs, Arun K. Ghosh
  • Nonpeptide HIV-1 protease inhibitors
    Patent number: 9085571
    Abstract: Novel compounds and compositions for treating patients in need of relief from HIV, AIDS and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: July 21, 2015
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • CCR5 antagonists for treating HIV
    Patent number: 9062057
    Abstract: Compounds that modulate the CCR5 chemokine receptor, pharmaceutical compositions containing them, and uses therefor in the treatment of HIV and related diseases are described.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: June 23, 2015
    Assignees: Purdue Research Foundation, Hiroaki Mitsuya
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Venkateswararao Kalapala, Jianfeng Li
  • Compunds and methods for treating HIV
    Patent number: 9024038
    Abstract: Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: May 5, 2015
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Bruno D. Chapsal, Hiroaki Mitsuya, Cuthbert D. Martyr
  • COMPOUNDS AND METHODS FOR TREATING AIDS AND HIV INFECTIONS
    Publication number: 20150111962
    Abstract: Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 23, 2015
    Inventor: Arun K. Ghosh
  • COMPOUNDS FOR INHIBITION OF MEMAPSIN 1
    Publication number: 20150080439
    Abstract: Various embodiments of the present invention relate to, among other things, compounds that are inhibitors of Memapsin 1 and, as a result, are effective in the treatment of Alzheimer's disease or diabetes (e.g., Type 2 diabetes).
    Type: Application
    Filed: September 12, 2014
    Publication date: March 19, 2015
    Inventor: Arun K. Ghosh
  • HIV-1 PROTEASE INHIBITORS HAVING GEM-DI-FLUORO BICYCLIC P2-LIGANDS
    Publication number: 20150072958
    Abstract: Various embodiments of the present invention relate to, among other things, compounds and methods of using those compounds to treat an HIV infection. The compounds of the various embodiments of the present invention provide, among other things, therapeutic agents having enhanced penetration capability across the blood-brain barrier, such that they can enter the CNS to treat an HIV-1 infection in the CNS.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 12, 2015
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Sofiya Yashchuk
  • Compounds and methods for treating AIDS and HIV infections
    Patent number: 8921349
    Abstract: Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: December 30, 2014
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • NONPEPTIDE HIV-1 PROTEASE INHIBITORS
    Publication number: 20140315946
    Abstract: Novel compounds and compositions for treating patients in need of relief from HIV, AIDS and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Inventor: Arun K. Ghosh
  • Inhibitors of BACE1 and methods for treating Alzheimer's disease
    Patent number: 8859590
    Abstract: Inhibitors of BACE1 and compositions containing them are described. Use of the inhibitors and compositions containing them to treat Alzheimer's disease are described.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: October 14, 2014
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
    Patent number: 8802724
    Abstract: The invention described herein pertains to processes and compounds useful in the preparation of bis-tetrahydrofurans. The invention described herein also pertains to compounds useful for treating HIV infections.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: August 12, 2014
    Assignee: Purdue Research Foundation
    Inventors: Arun K. Ghosh, Cuthbert D Martyr
  • CCR5 ANTAGONISTS FOR TREATING HIV
    Publication number: 20140221420
    Abstract: Compounds that modulate the CCR5 chemokine receptor, pharmaceutical compositions containing them, and uses therefor in the treatment of HIV and related diseases are described.
    Type: Application
    Filed: March 18, 2011
    Publication date: August 7, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Venkateswararao Kalapala, Jianfeng Li
  • Nonpeptide HIV-1 protease inhibitors
    Patent number: 8791135
    Abstract: Novel compounds and compositions for treating patients in need of relief from HIV, AIDS, and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: July 29, 2014
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh