Patents by Inventor Arun K. Ghosh

Arun K. Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSED TRICYCLIC ETHER CARBAMATES AND THEIR USE
    Publication number: 20140179754
    Abstract: Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.
    Type: Application
    Filed: October 8, 2013
    Publication date: June 26, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. GHOSH, Chun-Xiao Xu, Hiroaki Mitsuya, Garth Parham
  • C-3 SUBSTITUTED BICYCLOOCTANE BASED HIV PROTEASE INHIBITORS
    Publication number: 20140148508
    Abstract: C3-functionalized-cyclopentanyltetrahydrofuranyl carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are described. Compositions comprising the disclosed compound and methods of using the compounds and/or compositions for treating patients infected with HIV are also described.
    Type: Application
    Filed: July 11, 2012
    Publication date: May 29, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya, Bruno D. Chapsal
  • SMALL MOLECULE INHIBITORS OF HIV PROTEASES
    Publication number: 20140135321
    Abstract: Described herein are compounds, compositions, and methods for treating HIV and related diseases.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 15, 2014
    Inventor: Arun K. GHOSH
  • Compounds for treatment of Alzheimer's disease
    Patent number: 8703947
    Abstract: Described herein are compounds, and pharmaceutical compositions, methods, and uses thereof for treating Alzheimer's disease.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: April 22, 2014
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • Inhibitors of Memapsin 2 Cleavage for the Treatment of Alzheimer's Disease
    Publication number: 20140066488
    Abstract: Proteases such as memapsin 2 are important enzymes, playing roles in a variety of diseases including Alzheimer's Disease. The inventors have developed inhibitors of memapsin 2 and methods of use therefore in the treatment of disease.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Applicants: Purdue Research Foundation, Oklahoma Medical Research Foundation
    Inventors: Jordan Tang, Venkateswararao Kalapala, Arun K. Ghosh
  • PROCESSES AND INTERMEDIATES FOR PREPARING SUBSTITUTED HEXAHYDROFURO [2,3-b] FURANS
    Publication number: 20130338380
    Abstract: The invention described herein pertains to processes and compounds useful in the preparation of bis-tetrahydrofurans. The invention described herein also pertains to compounds useful for treating HIV infections.
    Type: Application
    Filed: November 30, 2011
    Publication date: December 19, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. Ghosh, Cuthbert D. Martyr
  • Method of treating HIV infection
    Patent number: 8597876
    Abstract: Disclosed is a method of treating human immunodeficiency virus (HIV) infection in an antiretroviral treatment-experienced mammal, which involves administering to the mammal an effective amount of a compound of the formula: or a pharmaceutically acceptable salt, a prodrug, or an ester thereof, or a pharmaceutically acceptable composition of the compound, the salt, the prodrug, or the ester thereof, wherein A, X, Q, W, m, and R2-R6 are as defined herein.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: December 3, 2013
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Board of Trustees of the University of Illinois
    Inventors: John W. Erickson, Sergei V. Gulnik, Hiroaki Mitsuya, Arun K. Ghosh
  • Synthesis of macrocyclic cancer chemotherapy agents and methods of use
    Patent number: 8580975
    Abstract: Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: November 12, 2013
    Assignee: Purdue Research Foundation
    Inventors: Arun K Ghosh, Xiaoming Xu
  • COMPOUNDS AND METHODS FOR TREATING HIV
    Publication number: 20130289067
    Abstract: Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described.
    Type: Application
    Filed: June 27, 2013
    Publication date: October 31, 2013
    Inventors: Arun K. GHOSH, Bruno D. Chapsal, Hiroaki Mitsuya
  • Fused tricyclic ether carbamates and their use
    Patent number: 8563597
    Abstract: Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are described. Methods of using the disclosed compounds for treating patients infected with HIV are also described.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: October 22, 2013
    Assignees: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Chun-Xiao Xu, Hiroaki Mitsuya, Garth Parham
  • HIV protease inhibitors and methods for using
    Patent number: 8501961
    Abstract: Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: August 6, 2013
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • FUSED TRICYCLIC ETHER CARBAMATES AND THEIR USE
    Publication number: 20130158094
    Abstract: Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.
    Type: Application
    Filed: September 2, 2011
    Publication date: June 20, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. Ghosh, Chun-Xiao Xu, Hiroaki Mitsuya, Garth Parham
  • PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20130102593
    Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 25, 2013
    Inventors: Geoffrey M. Bilcer, Thippeswamy Devasamudram, Sudha V. Ankala, John C. Lilly, Chunfeng Liu, Hui Lei, Arun K. Ghosh, Makoto Inoue
  • Quinazoline inhibitors of BACE 1 and methods of using
    Patent number: 8394807
    Abstract: There is provided a dihydroquinazoline compound of the formula or a pharmaceutically acceptable salt thereof, wherein the values of the radicals are defined herein, as well as a pharmaceutical composition containing the compound, and a method of using the compound for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: March 12, 2013
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20120295894
    Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: December 1, 2011
    Publication date: November 22, 2012
    Inventors: Geoffrey M. BILCER, Thippeswamy Devasamudram, Sudha V. Ankala, John C. Lilly, Chunfeng Liu, Hui Lei, Arun K. Ghosh, Makoto Inoue
  • (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating
    Patent number: 8299267
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: October 30, 2012
    Assignees: CoMentis, Inc., Purdue Research Foundation
    Inventors: Arun K. Ghosh, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa M. Swanson, Sudha V. Ankala, John C. Lilly, Geoffrey M. Bilcer
  • Lasonolide compounds as reagents for inducing premature chromosome condensation and methods for treating disorders
    Patent number: 8278100
    Abstract: The present invention is directed towards lasonolide derivatives, methods of inducing premature chromosome condensation using lasonolide derivatives, and methods of treating disorders, such as cancer, in a subject, the method comprising administering to the subject a lasonolide derivative.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: October 2, 2012
    Assignee: The United States of America, as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Yves Pommier, Yongwei Zhang, Arun K. Ghosh
  • PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20120214802
    Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 23, 2012
    Inventors: Geoffrey M. Bilcer, Thippeswamy Devasamudram, Sudha V. Ankala, John C. Lilly, Chunfeng Liu, Hui Lei, Arun K. Ghosh, Makoto Inoue
  • COMPOUNDS AND METHODS FOR TREATING AIDS AND HIV INFECTIONS
    Publication number: 20120059161
    Abstract: Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
    Type: Application
    Filed: May 11, 2010
    Publication date: March 8, 2012
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Arun K. Ghosh
  • INHIBITORS OF BACE1 AND METHODS FOR TREATING ALZHEIMER'S DISEASE
    Publication number: 20110275619
    Abstract: Inhibitors of BACE1 and compositions containing them are described. Use of the inhibitors and compositions containing them to treat Alzheimer's disease are described.
    Type: Application
    Filed: December 4, 2009
    Publication date: November 10, 2011
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Arun K. Ghosh