Patents by Inventor Ben SASSON

Ben SASSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6121236
    Abstract: Disclosed are novel multivalent ligands represented by the following structural formula: ##STR1## B is a multilinker backbone. n is an integer from two to about twenty.Each L is a covalent bond or linking group.Each P is a peptide having from about 10 to about 30 amino acid residues. At least two of the peptides P are a peptide derivative of an AHR of an angiogenic protein, a hybrid peptide, a peptide derivative of a hybrid peptide or a combination thereof. Each peptide and each linker or covalent bond is independently chosen. The disclosed multivalent ligands can be used to modulate angiogenesis in a mammal.Also disclosed are novel peptide derivatives of an AHR of an angiogenic protein, novel hybrid peptides, peptide derivatives of the novel hybrid peptides and polypeptide multivalent ligands thereof.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: September 19, 2000
    Assignee: The Children's Medical Center Corporation
    Inventor: Shmuel A. Ben-Sasson
  • Patent number: 5674482
    Abstract: A biologically active polymeric compound comprising an alkylaryl or heteroalkylaryl backbone having about 5 to about 50 repeating aromatic ring-containing units and which, according to the computer program marketed as SYBYL.RTM. version 5.2 running on a DEC VAX.RTM. 11/750 computer, is capable of forming a linear backbone having a helical secondary structure, and wherein the maximum diameter of the helical structure, as measured by the alkylaryl or heteroalkylaryl backbone, is less than 3 times greater than the maximum diameter of the aryl group of the alkylaryl or heteroalkylaryl backbone.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: October 7, 1997
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals, Inc.
    Inventors: John R. Regan, Michael N. Chang, Jack Newman, Schmuel Ben-Sasson
  • Patent number: 5571506
    Abstract: This invention relates to aromatic oligomeric compounds useful in the treatment of cardiovascular, bone metabolic, hypolipidaemic, neuronal, gastrointestinal and elastase-mediated connective tissue degradation disorders and disorders which may be treated by agents effective in binding DNA, to processes for preparation of such oligomeric compounds, to pharmaceutical compositions including such oligomeric compounds, and to their use in the treatment of such disorders.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: November 5, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John R. Regan, Daniel G. McGarry, Michael N. Chang, Jeffrey N. Barton, Jack Newman, Schmuel Ben-Sasson
  • Patent number: 4840795
    Abstract: The present invention relates to the aluminum hydroxide having a specific surface area of at least 350 m.sup.2, preferably at least 400 m.sup.2, per g. and to a process for its preparation. The aluminum hydroxide should be capable of absorbing at least 1 g of fat per g. of material. The aluminum hydroxide is preferably part of a pharmaceutical preparation.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: June 20, 1989
    Assignee: Rafa Laboratories
    Inventor: Shmuel Ben-Sasson
  • Patent number: 4780307
    Abstract: The present invention relates to the aluminum hydroxide having a specific surface area of at least 350 m.sup.2, preferably at least 400 m.sup.2, per g. and to a process for its preparation. The aluminum hydroxide should be capable of absorbing at least 1 g of fat per g. of material. The aluminum hydroxide is preferably part of a pharmaceutical preparation.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: October 25, 1988
    Assignee: Rafa Laboratories Ltd.
    Inventor: Shmuel Ben-Sasson