Patents by Inventor Ben SASSON

Ben SASSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of modulating G-protein-coupled receptor kinase-associated signal transduction
    Patent number: 7037891
    Abstract: The present invention concerns methods for the treatment of metabolic-related diseases by the modulation of GRK associated signal transduction. Preferred in accordance with the invention are modulators which comprise sequences derived from specific regions of the GRK.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: May 2, 2006
    Assignees: Children's Medical Center Corporation, Yissum Research and Development
    Inventor: Shmuel Ben-Sasson
  • Compositions capable of facilitating penetration across a biological barrier
    Publication number: 20050232981
    Abstract: This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium. The invention also relates to methods of treating or preventing diseases by administering such penetrating compositions to affected subjects.
    Type: Application
    Filed: April 14, 2005
    Publication date: October 20, 2005
    Inventor: Shmuel Ben-Sasson
  • Amino acid sequences capable of facilitating penetration across a biological barrier
    Publication number: 20050215478
    Abstract: The invention relates to amino acid sequences capable of facilitating penetration of an effector across a biological barrier. The invention also relates to methods of treating preventing diseases by administering or penetrating modules to affected subjects.
    Type: Application
    Filed: February 7, 2003
    Publication date: September 29, 2005
    Inventors: Shmuel Ben-Sasson, Einat Cohen
  • Anti-cancer combination and use thereof
    Publication number: 20050148521
    Abstract: The present invention relates to the surprising discovery that the combination of several agents, each well known for its established role in treating cancer, inflammation, hemostasis, bone resorption or serving as a solubilizing vehicle, results in a synergistic anti-cancer composition. Furthermore, the combination of at least three agents allows the cytotoxic agent, such as cyclophosphamide, to be used at a lower dosage than when administered alone. One predicted consequence of this treatment, therefore, is a highly desirable reduction in toxic side effects due to the cytotoxic agent.
    Type: Application
    Filed: July 23, 2004
    Publication date: July 7, 2005
    Applicants: Yissum Research Development Company of the Hebrew University, The Children's Medical Center Corporation
    Inventors: Shmuel Ben-Sasson, Lilia Tsirulnikov, Vladimir Vainstein
  • Compositions capable of facilitating penetration across a biological barrier
    Publication number: 20050136103
    Abstract: This invention relates to novel pharmaceutical compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering these compositions to affected subjects.
    Type: Application
    Filed: September 16, 2004
    Publication date: June 23, 2005
    Inventors: Shmuel Ben-Sasson, Einat Cohen
  • Compositions capable of facilitating penetration across a biological barrier
    Publication number: 20050058702
    Abstract: This invention relates to novel pharmaceutical compositions mixing one or more effectors (anionic impermeable molecules) with a counter ion to the effector (a liquid forming cation). The invention also relates to methods of treating or preventing diseases by administering pharmaceutical compositions to affected subjects.
    Type: Application
    Filed: September 17, 2003
    Publication date: March 17, 2005
    Inventors: Shmuel Ben-Sasson, Einat Cohen
  • Short peptides which selectively modulate the activity of serine/threonine kinases
    Patent number: 6833436
    Abstract: Disclosed are peptides which are peptide derivatives of the HJ loop of a serine/threonine kinase. The peptides can modulate the activity of the serine/threonine kinase. Also disclosed are methods of modulating the activity of a serine/threonine kinase in a subject by administering one of the peptides of the present invention.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: December 21, 2004
    Assignees: Children's Medical Center Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Shmuel A. Ben-Sasson
  • Tissue remodeling
    Publication number: 20040254116
    Abstract: The invention concerns a method for the modulation of tissue-remodeling processes, by contacting the tissue to be remodeled with a compound comprising a sequence derived from certain regions of TGF-&bgr; super family Ser/Thr/kinase receptors.
    Type: Application
    Filed: July 2, 2004
    Publication date: December 16, 2004
    Applicants: Children's Medical Center Corporation, Yissum Research and Development
    Inventor: Shmuel Ben-Sasson
  • Tissue remodeling
    Patent number: 6770626
    Abstract: The invention concerns a method for the modulation of tissue-remodeling processes, by contacting the tissue to be remodeled with a compound comprising a sequence derived from certain regions of TGF-&bgr; super family Ser/Thr/kinase receptors.
    Type: Grant
    Filed: December 31, 2001
    Date of Patent: August 3, 2004
    Assignees: Children's Medical Center Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Shmuel Ben-Sasson
  • Amino acid sequences capable of facilitating penetration across a biological barrier
    Publication number: 20040146549
    Abstract: This invention relates to novel pharmaceutical penetration compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering penetration compositions to affected subjects.
    Type: Application
    Filed: September 17, 2003
    Publication date: July 29, 2004
    Inventors: Shmuel A. Ben-Sasson, Einat Cohen
  • Treatment of cancer
    Publication number: 20040121952
    Abstract: The present invention concerns methods for the treatment of solid tumors by the inhibition of Lyn associated signal transduction. Preferred in accordance with the invention are inhibitors which comprise sequences derived from specific regions of the Lyn. The present invention further concerns a method for the treatment of cancer by the administration of compounds comprising Lyn-derived peptides.
    Type: Application
    Filed: June 6, 2003
    Publication date: June 24, 2004
    Applicants: Children's Medical Center Corporation, Yissum Research and Development
    Inventors: Shmuel Ben-Sasson, Hadas Reuveni
  • Short peptides which selectively modulate intracellular signalling
    Patent number: 6723694
    Abstract: Disclosed are peptides which are peptide derivatives of the HJ loop of a protein tyrosine kinase. The peptides can modulate the activity of the protein tyrosine kinase. Also disclosed are methods of modulating the activity of a protein tyrosine kinase in a subject by administering one of the peptides of the present invention.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: April 20, 2004
    Assignees: The Children's Medical Center Corp., Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Shmuel A. Ben-Sasson
  • Short peptides which selectively modulate the activity of protein kinases
    Patent number: 6723830
    Abstract: Peptides which are peptide derivatives of the &agr;D region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by administering one or more of these peptides.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: April 20, 2004
    Assignees: Children's Medical Center Corporation, Yissum Research and Development
    Inventor: Shmuel A. Ben-Sasson
  • Short peptides from the b4 and b5 regions kinases which selectively modulate protein activity
    Publication number: 20030211589
    Abstract: Peptides which are peptide derivatives of the B4-5 region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by administering one or more of these peptides.
    Type: Application
    Filed: October 23, 2002
    Publication date: November 13, 2003
    Inventor: Shmuel Ben-Sasson
  • Water-supply pack assembly
    Patent number: 6513686
    Abstract: A water-supply pack assembly adapted to hitch onto the driver's seat in an automobile, thereby making it possible for the driver to drink water drawn from the supply without having to interrupt his driving activity The assembly includes a fixture attachable to the headrest of the driver's seat and a water-supply pack mountable on the fixture so that it is then behind the back of the seat. A flexible tube extending from the outlet of the supply and terminating in a valved mouthpiece functions as a straw to permit the driver with the mouthpiece in place to suck water from the supply as he drives the vehicle.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: February 4, 2003
    Inventor: Amit Ben-Sasson
  • Modulators of activity of G-protein-coupled receptor kinases
    Publication number: 20030004103
    Abstract: The present invention concerns methods for the treatment of metabolic-related diseases by the modulation of GRK associated signal transduction. Preferred in accordance with the invention are modulators which comprise sequences derived from specific regions of the GRK.
    Type: Application
    Filed: December 11, 2001
    Publication date: January 2, 2003
    Applicant: Children's Medical Center Corporation
    Inventor: Shmuel Ben-Sasson
  • Method and system for dynamically replacing a component in a communication system
    Publication number: 20020167490
    Abstract: Disclosed is a method for replacing a remote unit in a communication system. The method includes the steps of determining that a removed remote unit has been removed from the communication system. The method also includes the step of determining that a new remote unit has been installed in the place of the removed remote unit. The steps of the method further include recalling parameters associated with the removed remote unit and providing the recalled parameters associated with the removed remote unit to the new remote unit.
    Type: Application
    Filed: January 10, 2002
    Publication date: November 14, 2002
    Inventors: Haim Weissman, Victor H. Ben-Sasson, Itsik Boger
  • Tissue remodeling
    Publication number: 20020165150
    Abstract: The invention concerns a method for the modulation of tissue-remodeling processes, by contacting the tissue to be remodeled with a compound comprising a sequence derived from certain regions of TGF-&bgr; super family Ser/Thr/kinase receptors.
    Type: Application
    Filed: December 31, 2001
    Publication date: November 7, 2002
    Applicant: Children's Medical Center Corporation
    Inventor: Shmuel Ben-Sasson
  • Short peptides which selectively modulate the activity of protein kinases
    Publication number: 20020160478
    Abstract: Peptides which are peptide derivatives of the &agr;D region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by administering one or more of these peptides.
    Type: Application
    Filed: January 8, 2002
    Publication date: October 31, 2002
    Applicant: Children's Medical Center Corporation
    Inventor: Shmuel A. Ben-Sasson
  • Treatment of prostate cancer by inhibiting Lyn tyrosine kinase
    Publication number: 20020151497
    Abstract: The present invention concerns methods for the treatment of prostate cancer by the inhibition of Lyn-kinase associated signal transduction. Preferred in accordance with the invention are inhibitors which comprise sequences derived from specific regions of the Lyn-kinase.
    Type: Application
    Filed: December 11, 2001
    Publication date: October 17, 2002
    Applicant: Children's Medical Center Corporation
    Inventor: Shmuel Ben-Sasson