Abstract: Systems and methods for training a machine-learned model are disclosed herein. The method can include obtaining, by a processor, a plurality of images, each image having a set of parameter values comprising values for a plurality of camera parameters and determining a covariance matrix for the plurality of camera parameters with respect to a plurality of projected points generated via evaluation of a projection function. The method can also include performing a whitening algorithm to identify a preconditioning matrix that, when applied to the sets of parameter values, results in the covariance matrix being approximately equal to an identity matrix and performing an optimization algorithm on the plurality of sets of parameter values, Performing the optimization algorithm can include applying an inverse of the preconditioning matrix to the plurality of sets of parameters in a forward prediction pass and applying the preconditioning matrix in a backward gradient pass.

Abstract: The invention provides a connector for attaching a first part to a second part in a connection joint, the connector comprising a body attachable to the first part and comprising link element extending from the body, wherein the link comprises substantially opposing surfaces, each surface comprising a curved region configured to nest with a complimentary curved region of a washer of the connection joint, and further comprising an opening located substantially centrally within each curved region of the arm and passing through the arm.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: A compound of formula (I): wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

Abstract: The present disclosure relates to engineered T cells and methods of making and using the same, as well as reagents for making the engineered T cells.

Abstract: The present invention relates generally to nitric oxide (NO) releasing nasal compositions and to methods of using the same.

Abstract: Systems and methods for training a neural radiance field model for noisy scenes can leverage raw noisy images in linear high dynamic range color space to train a neural radiance field model to generate view synthesis of low light and/or high contrast scenes. The trained model can then be utilized to accurately complete view rendering tasks without the preprocessing used for generating low dynamic range images. In some implementations, training on unprocessed data of a low light scene can allow for training a neural radiance field model to generate high quality view renderings of a low light scene.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: A computer-implemented method for generating personalized multimedia, is disclosed. The computer-implemented method includes determining one or more multimedia preferences associated with a user. The computer-implemented method further includes analyzing multimedia data to generate a personalized audio output based, at least in part, on the one or more multimedia preferences associated with the user. The computer-implemented method further includes modifying the multimedia data to include the generated personalized audio output using a generative adversarial network.

Abstract: Methods of partition-based analysis. In an exemplary method, a device having a port fluidically connected to a chamber may be selected. A sample-containing fluid may be placed into the port. The sample-containing fluid may be moved from the port to the chamber. Partitions of the sample-containing fluid may be formed. A monolayer of the partitions in the chamber may be created. At least a portion of the monolayer may be imaged.

Abstract: Embodiments disclosed herein provide an organic matter processing apparatus and method for the use thereof to convert organic matter into a ground and desiccated product. This can be accomplished using a bucket assembly that can grind, paddle, and heat organic matter contained therein. An algorithm is used to control the conversion of organic input to organic output by progressing through processing states based, in part, on time windows, runtimes, and sensor inputs.

Abstract: The present disclosure relates to a genetically modified host cell having increased production of one or more vitamin B compounds, wherein the host cell is genetically modified by mutating one or more native polynucleotide constructs for reducing formation of a CRP-cAMP complex in the host cell and/or introducing one or more genetic alterations increasing the degradation and/or non-CRP binding of cAMP in the host cell; whereby the production of the vitamin B compound in the genetically modified host cell is increased compared to a parent host cell.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: The present disclosure is directed toward systems, methods, and non-transitory computer readable media for generating content clusters from topic data and focus data, generating content collections from content clusters, storing and restoring desktop scene layouts, and storing and arranging video call scenes. In some embodiments, the disclosed systems generate content clusters based on topic data and focus data associated with content items within a content management system and/or accessed via the internet. The disclosed systems can also generate content collections for a user account of the content management system from the content clusters. In some embodiments, the content scene system can further store and restore desktop scene layouts for arranging application windows presenting content items. Further, the disclosed systems can store and arrange particular desktop scene layouts for video call scenes.

Abstract: A fractional training process can be performed training images to an instance of a machine-learned generative image model to obtain a partially trained instance of the model. A fractional optimization process can be performed with the partially trained instance to an instance of a machine-learned three-dimensional (3D) implicit representation model obtain a partially optimized instance of the model. Based on the plurality of training images, pseudo multi-view subject images can be generated with the partially optimized instance of the 3D implicit representation model and a fully trained instance of the generative image model; The partially trained instance of the model can be trained with a set of training data. The partially optimized instance of the machine-learned 3D implicit representation model can be trained with the machine-learned multi-view image model.

Abstract: A method to reconstruct an environment is provided. The method makes available to a wide variety of XR applications fresh and accurate 3D reconstruction data of environments with low processing time and low usage of computational resources and storage spaces. The 3D reconstruction data are structured in a way to be efficiently shared between users for multi-user experiences. The method includes obtaining plane segments of an environment, identifying surface planes of the environment by, for example, filtering and grouping the plane segments or ad hoc selection of the plane segments by a user, and inferring corner points of the environment based on the surface planes. The corner points are used to build a 3D representation of the environment when an XR application requires.

Abstract: Embodiments disclosed herein provide an organic matter processing apparatus and method for the use thereof to convert organic matter into a ground and desiccated product. This can be accomplished using a bucket assembly that can grind, paddle, and heat organic matter contained therein. An algorithm is used to control the conversion of organic input to organic output by progressing through processing states based, in part, on time windows, runtimes, and sensor inputs.

Abstract: Methods, systems, apparatuses, and non-transitory computer-readable media are provided for synthetic inertia for energy systems. In one implementation, the computer-readable media may include instructions to cause a processor to: obtain a rate of change of a frequency of alternating current of an electrical grid; determine a mapping between the rate of change of the frequency and an amount of change of output power for energy storage unit(s) coupled to the electrical grid; calculate, based on the mapping and the rate of change of the frequency, an amount of change of the output power for the energy storage unit(s); determine, based on a reference output power and the calculated amount of change, an adjusted output power; and configure, based on the adjusted output power, the energy storage unit(s) to output electricity to the electrical grid.

Abstract: The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.