Abstract: The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

Abstract: Systems and methods for settling disputed claims and avoiding arbitration are provided. A set of settled medical claims is used to train a model to predict the settlement amount of a medical claims based on a variety of attributes of the claim. Later, when an insurance payor disputes a claim sent by a medical provider, the model is used to predict a settlement amount based on the attributes of the disputed claim. This predicted settlement amount is then sent to the payor and the medical provider as a proposed settlement amount for the disputed claim in a user interface. The medical provider and payor can either accept the proposed settlement amount or can provide a counter settlement amount through the user interface. Once both parties agree on the settlement amount, the disputed claim is settled and arbitration is avoided.

Abstract: Provided herein, inter alia, are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells (e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

Abstract: Methods and systems for the secure delivery and processing of exam questions and responses. One or more exam questions and one or more identifiers of one or more designated individuals who are authorized to print the one or more exam questions are transported using a secure protocol. Biometric information is obtained from an individual requesting to print the one or more exam questions and information is read from an embedded tag that identifies a corresponding exam sheet as a unique exam sheet for a specified exam and that identifies that the specified exam is for a particular student. The specified exam is printed on the unique exam sheet in response to a first current time being in a printing time window TW1 and the biometric information from the individual matching biometric information of one of the one or more designated individuals.

Abstract: In an embodiment, systems and method for detecting errors in prescriptions are provided. When a prescription for a medication is received by a prescription fulfillment system, the instructions associated with the prescription are analyzed to determine where the prescription for the medication includes a mistake. The analysis may be performed based on information collected from a plurality of prescriptions for the same medication that are known to not include any mistakes. If a prescription is determined to possibly include a mistake one or more actions may be taken including notifying a pharmacist, notifying the medical provider associated with the prescription, notifying the patient, and in some circumstances, rejecting the prescription. In some embodiments, the analysis may be performed by a model trained using the plurality of prescriptions known to not include any mistakes, and a plurality of prescriptions known to include some mistakes.

Abstract: Some implementations of the disclosure are directed to detachable endoscope shafts assemblies including detachable endoscope shafts. In one implementation, an endoscope assembly comprises: an endoscope housing comprising a distal connector including first circuitry configured to receive one or more image signals or supply power from the endoscope housing; and a detachable endoscope shaft comprising: a distal segment configured to be inserted in a patient cavity; an attachment segment proximal to the distal segment, the attachment segment configured to be removably coupled to an instrument or adapter; and a proximal connector configured to removably and electrically couple to the distal connector, the proximal connector including second circuitry configured to electrically couple to the first circuitry.

Abstract: An articulating cannula assembly is described. The articulating cannula assembly includes: a hand piece; a proximal housing situated above the hand piece; a cannula distally extending from the proximal housing, the cannula including an articulating segment; and a trigger that, when actuated, extends or contracts the articulating segment. The proximal housing can removably couple to the hand piece. The proximal housing can include an endoscope attachment structure for removably securing a proximal portion of an endoscope.

Abstract: Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system.

Abstract: Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system.

Abstract: A compound of formula (I): wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

Abstract: A device may include an anchor point operationally connected to a rebar, an E-clamp coupled to the anchor point, and a forcing handle configured to tighten the E-clamp to the rebar.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for rendering a new image that depicts a scene from a perspective of a camera at a new camera viewpoint.

Abstract: Systems and methods for electrochemical ammonia synthesis comprise electrolytes which have greater efficiency than water, thus leading to cost reductions; and/or cathode catalysts which have lower costs and higher efficiencies in comparison to the iron/nickel catalysts noted above. The electrolyte may be composed primarily of a combination of non-aqueous hydrogen bond donors and acceptors, with high nitrogen solubility and high conductivity. The cathode catalyst may be composed of either a manganese-doped oxide or carbonate material or a two-dimensional carbide or nitride material.

Abstract: The invention relates to methods of treating COVID-19 in a patient by administering therapeutically effective amounts of certain SARS-CoV-2 inhibitor compounds or pharmaceutical compositions containing them to a patient in need thereof.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: An emergency call is initiated on behalf of a remote user by another software user who determines that the remote software user is experiencing an emergency event. During a real-time communication, a remote emergency alert is received from a first client device associated with a first user. The remote emergency alert identifies a second user associated with a second client device while the first client device and the second client device are in communication via real-time communication software. Based on location information determined for the second client device responsive to the remote emergency alert, an emergency call is initiated with a public safety answering point local to the second client device for indicating an emergency event associated with the second user to the public safety answering point on behalf of the second user.

Abstract: Some implementations of the disclosure are directed to detachable endoscope shafts assemblies including detachable endoscope shafts. In one implementation, an endoscope assembly comprises: an endoscope housing comprising a distal connector including first circuitry configured to receive one or more image signals or supply power from the endoscope housing; and a detachable endoscope shaft comprising: a distal segment configured to be inserted in a patient cavity; an attachment segment proximal to the distal segment, the attachment segment configured to be removably coupled to an instrument or adapter; and a proximal connector configured to removably and electrically couple to the distal connector, the proximal connector including second circuitry configured to electrically couple to the first circuitry.

Abstract: Aircraft, aircraft wings and associated shear ties are disclosed. An example apparatus includes a first panel coupled to a second panel to define a wing box; a rib disposed chordwise within the wing box; and a stringer disposed spanwise within the wing box immediately adjacent at least one of the first panel or the second panel, the rib including a shear tie including first and second legs extending in opposite directions, the first and second legs to be coupled to at least one of the first panel, the second panel, or the stringer.

Abstract: A compound of formula (I), wherein R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

Abstract: Embodiments disclosed herein provide an organic matter processing apparatus and method for the use thereof to convert organic matter into a ground and desiccated product. The organic matter processing apparatus includes a lid assembly that is positioned at the top or head of the processing apparatus and an air treatment system. The lid assembly is operative to open to allow a user to deposit organic matter into the processing apparatus or to remove a removable bucket contained therein. The lid assembly is operative to close and provide an odor containing seal that prevents or substantially mitigates escape of odor. The air treatment system uniformly distributes untreated air through an air treatment chamber to convert the untreated air to treated air, which is exhausted out of the processing apparatus.