Abstract: The present invention provides a therapeutic agent for progressive disease caused by an increase in Eomes-positive CD4-positive T cells, comprising a compound represented by formula (I) or a salt thereof as an active ingredient. In the formula, R1 is an aldopyranose residue, R2 is a hydrogen atom or a hydroxy group, R3 is —CH2—, —CH(OH)—CH2—, or —CH?CH—, R4 is a hydrogen atom or CH3, x is 0 to 35, and y and z each are an integer satisfying y+z=0 to 3.

Abstract: Systems and methods for providing supplemental information with a response to a command are provided herein. In some embodiments, audio data representing a spoken command may be received by a cloud-based information system. A response to the command may be retrieved from a category related to the context of the command. A supplemental information database may also be provided that is pre-populated with supplemental information related to an individual having a registered account on the cloud-based information system. In response to retrieving the response to the command, supplemental information may be selected from the supplemental information database to be appended to the response to the command. A message may then be generated including the response and the supplemental information appended thereto, which in turn may be converted into audio data representing the message, which may be sent to a voice-controlled electronic device of the individual.

Abstract: A tilt sensor includes a one-way rotational drive configured to translate rotational motion of an input shaft in a first rotational direction about a first axis of the input shaft and in a second rotational direction about the first axis into rotational movement in a first rotational direction about a second axis of an output shaft. The tilt sensor further includes a pendulum coupled to the input shaft. The pendulum is configured to rotate the input shaft in the first rotational direction or the second rotational direction responsive to a tilt motion of the tilt sensor. The tilt sensor further includes a motion meter coupled to the output shaft. The motion meter is configured to display a measure of total tilt motion of the tilt sensor.

Abstract: A lightshow control system for generating a lightshow across a plurality of pixels or mobile devices comprises a controller configured to receive a lightshow operator's input and to generate a plurality of lightshow parameters. The system comprises a beacon transmitter in communication with the lightshow controller and configured to receive the lightshow parameters from the lightshow controller, encode the lightshow parameters on a beacon signal, and broadcast the beacon signal to the pixels, wherein each pixel is configured to receive and decode the beacon signal to perform one or more display actions. The decoded beacon signal includes reference timing information to facilitate synchronization of the pixels. The display actions may be based in part on the individual pixel location which is determined by the pixel based on TDOA multilateration and/or trilateration from distinct audio signals emitted by a plurality of speaker nodes.

Abstract: The present disclosure is directed toward systems, methods, and non-transitory computer readable media for providing a creativity web browser for content creation that integrates features of a content management system with internet browsing capabilities. Specifically, the disclosed systems provide a creativity web browser that includes specialized interface elements for restructuring web browsing to focus on content-related context, including a digital canvas, a content collection pane, an x-ray pane, and other elements. The disclosed systems can provide access to browsing across multiple systems or platforms, such as internet locations and/or locations within a content management system, within an integrated web browsing environment.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: Compositions containing a nucleic acid nanostructure having a desired geometric shape and immunostimulatory agent(s) bound to its surface are provided. The nanostructures can be, for example, in the form of a 6-helix bundle, or icosahedron, or a pentagonal bipyramid. The nanostructure design allows for control of the relative position and/or stoichiometry of the immunostimulatory agent(s) bound to its surface. The immunostimulatory agent(s) displayed on the nanostructure surface are arranged with the preferred number, spacing, and 3D organization to elicit a robust immune response. The displayed antigen can be a TLR agonist, such as a TLR9 agonist. The immunostimulatory compositions may thus be useful as immunogens, vaccines, adjuvants, and the like. Methods of inducing immune responses, and for targeted induction of TLR activation are also provided.

Abstract: Some implementations of the disclosure are directed to detachable endoscope shafts assemblies including detachable endoscope shafts. In one implementation, an endoscope assembly comprises: an endoscope housing comprising a distal connector including first circuitry configured to receive one or more image signals or supply power from the endoscope housing; and a detachable endoscope shaft comprising: a distal segment configured to be inserted in a patient cavity; an attachment segment proximal to the distal segment, the attachment segment configured to be removably coupled to an instrument or adapter; and a proximal connector configured to removably and electrically couple to the distal connector, the proximal connector including second circuitry configured to electrically couple to the first circuitry.

Abstract: The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

Abstract: Systems and methods for settling disputed claims and avoiding arbitration are provided. A set of settled medical claims is used to train a model to predict the settlement amount of a medical claims based on a variety of attributes of the claim. Later, when an insurance payor disputes a claim sent by a medical provider, the model is used to predict a settlement amount based on the attributes of the disputed claim. This predicted settlement amount is then sent to the payor and the medical provider as a proposed settlement amount for the disputed claim in a user interface. The medical provider and payor can either accept the proposed settlement amount or can provide a counter settlement amount through the user interface. Once both parties agree on the settlement amount, the disputed claim is settled and arbitration is avoided.

Abstract: Provided herein, inter alia, are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells (e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

Abstract: Methods and systems for the secure delivery and processing of exam questions and responses. One or more exam questions and one or more identifiers of one or more designated individuals who are authorized to print the one or more exam questions are transported using a secure protocol. Biometric information is obtained from an individual requesting to print the one or more exam questions and information is read from an embedded tag that identifies a corresponding exam sheet as a unique exam sheet for a specified exam and that identifies that the specified exam is for a particular student. The specified exam is printed on the unique exam sheet in response to a first current time being in a printing time window TW1 and the biometric information from the individual matching biometric information of one of the one or more designated individuals.

Abstract: Some implementations of the disclosure are directed to detachable endoscope shafts assemblies including detachable endoscope shafts. In one implementation, an endoscope assembly comprises: an endoscope housing comprising a distal connector including first circuitry configured to receive one or more image signals or supply power from the endoscope housing; and a detachable endoscope shaft comprising: a distal segment configured to be inserted in a patient cavity; an attachment segment proximal to the distal segment, the attachment segment configured to be removably coupled to an instrument or adapter; and a proximal connector configured to removably and electrically couple to the distal connector, the proximal connector including second circuitry configured to electrically couple to the first circuitry.

Abstract: In an embodiment, systems and method for detecting errors in prescriptions are provided. When a prescription for a medication is received by a prescription fulfillment system, the instructions associated with the prescription are analyzed to determine where the prescription for the medication includes a mistake. The analysis may be performed based on information collected from a plurality of prescriptions for the same medication that are known to not include any mistakes. If a prescription is determined to possibly include a mistake one or more actions may be taken including notifying a pharmacist, notifying the medical provider associated with the prescription, notifying the patient, and in some circumstances, rejecting the prescription. In some embodiments, the analysis may be performed by a model trained using the plurality of prescriptions known to not include any mistakes, and a plurality of prescriptions known to include some mistakes.

Abstract: An articulating cannula assembly is described. The articulating cannula assembly includes: a hand piece; a proximal housing situated above the hand piece; a cannula distally extending from the proximal housing, the cannula including an articulating segment; and a trigger that, when actuated, extends or contracts the articulating segment. The proximal housing can removably couple to the hand piece. The proximal housing can include an endoscope attachment structure for removably securing a proximal portion of an endoscope.

Abstract: Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system.

Abstract: Methods and systems are provided for Z-pinch plasma and other plasma confinement utilizing various electrode compositions and configurations. In one example, a plasma confinement system includes a plurality of electrodes, each electrode of the plurality of electrodes arranged coaxially with respect to an assembly region of the plasma confinement system and positioned so as to be exposed to the assembly region, wherein one or more electrodes of the plurality of electrodes includes an electrode material which releases hydrogen gas above a threshold temperature. In an additional or alternative example, a plasma confinement system includes an electrode body including a nosecone, and a liquid metal, a portion of the liquid metal forming a protective film between a surface of the nosecone and an exterior of the nosecone during operation of the plasma confinement system.

Abstract: A compound of formula (I): wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

Abstract: A device may include an anchor point operationally connected to a rebar, an E-clamp coupled to the anchor point, and a forcing handle configured to tighten the E-clamp to the rebar.