Abstract: Described herein is a method for treating or restoring loss of hearing and balance in a subject in need thereof. In certain aspects, the disclosed method is comprised of transplanting a humanized otocyst to a target delivery site in the subject. According to certain aspects, the otocyst is obtained from a humanized non-human mammal embryo. In certain exemplary aspects, the non-human mammal is a pig. In certain embodiments, prior to transplantation, the otocyst is cultured in a species-specific tissue culture buffer.

Abstract: A separating system for separating individual container products from a frame assembly of plastic material, particularly polypropylene, has at least one stamping device (36) that at least partially separates the respective container product from a frame waste. By the stamping device (36) including a free fall body (52) separating the respective frame waste from the associated container product from an initial position during free fall, the separation can be carried out with very high speed (free fall) and additional mechanical components for applying a constraint force on the stamping body during the creating of the separating line can be omitted.

Abstract: A separating device for separating individual container products from a frame assembly of plastic material, particularly polypropylene, has at least one stamping device (36) that at least partially separates the respective container product from a frame waste. By the stamping device (36) including a free fall body (52) separating the respective frame waste from the associated container product from an initial position during free fall, the separation can be carried out with very high speed (free fall) and additional mechanical components for applying a constraint force on the stamping body during the creating of the separating line can be omitted.

Abstract: A container of a plastic material is produced using a blow-fill-seal method, and has a container body (1) for receiving a fluid as well as a neck section (5) connected to the container body (1). At the container free end, a dispensing opening (13) for fluid is sealed via a separating region (15, 19) with a head section (17) that can be removed from the neck section (5) by actuating a movable sleeve section (35). By releasing the separating region (15, 19), the dispensing opening (13) is exposed. From the unactuated state to the actuated state in which the separating region (15, 19) is released, the sleeve section (35) is guided so as to be at least partially in contact with a guide path (23) that is part of the removable head section (17).

Abstract: The invention relates to a container, which consists in particular of a plastic material, is produced using a blow-fill-seal method, and comprises a container body (1) for receiving a fluid as well as a neck section (5) that is connected to said container body (1) and has, at its free end, a dispensing opening (13) for said fluid which is sealed, via a separating region (15, 19), with a head section (17) that can be removed from the neck section (5) by actuating a movable sleeve section (35), by releasing the separating region (15, 19) such that said dispensing opening (13) is exposed. The invention is characterized in that, from the unactuated state to the actuated state in which the separating region (15, 19) is released, the sleeve section (35) is guided so as to be at least partially in contact with a guide path (23) that is part of the removable head section (17).

Abstract: A receptacle, particularly a closed plastic ampoule produced in a blow molding method and filled in the mold, has a sleeve-type neck part (1) connected to a receptacle body (3) as an axial extension. The neck part forms a seat (11) for a pre-shaped insert (5) and is integrally molded in the mold onto a circumferential surface (9) of the insert (5). The circumferential surface (9) is equipped with at least one surface irregularity (21) having an enclosed base surface such that, due to the integral molding of the neck part (1) onto the circumferential surface (9) of the insert (5), a positive fit is present between the insert and the neck part (1). The fit forms a fixing element. The axial extension of the base surface of the surface irregularity (21) is only a small fraction of the axial extension of the circumferential surface (9).

Abstract: A method produces an applicator for applying liquid or pasty media (1), having a container (3) storing the medium (1), and an application element (5, 13) attached to the container (3) in a usage position such that the application element provides the medium (1) for application outside the container (3) by capillary action. A hose of thermoplastic plastic is extruded and inserted into a mold, forming a container (3) closed at the bottom by expanding the hose in the mold. The container (3) located in the mold is filled with the medium (1). The container (3) is separated from the hose to form an opening accessible at the top side of the container (3). The application element (5, 13) is put into the usage position by inserting the application element through the opening of the hose and fastening the application element (5, 13) while simultaneously creating a closure of the container (3) by moving movable mold parts of the mold.

Abstract: A separating system for separating individual container products from a frame assembly of plastic material, particularly polypropylene, has at least one stamping device (36) that at least partially separates the respective container product from a frame waste. By the stamping device (36) including a free fall body (52) separating the respective frame waste from the associated container product from an initial position during free fall, the separation can be carried out with very high speed (free fall) and additional mechanical components for applying a constraint force on the stamping body during the creating of the separating line can be omitted.

Abstract: A method produces and fills containers (1) made of thermoplastic plastic, in which an extruded plastic hose is inserted into an open mold having movable mold parts. The mold parts forming the container (1) are closed. The hose is expanded by a pressure gradient acting on the hose to form the container (1), preferably in the form of a bellows. The container is filled with filling material. The level of the filling material is raised by reducing container volume in the direction of the container opening. A container closure (5) for the container opening is formed from the hose by closing head jaws of the mold. In the region of the container closure (5), one section of the plastic hose remains unclosed to form a venting cannula (3). When the container volume is reduced, the level of the filling material is raised such that at least air is displaced from the container (1) through venting cannula (3). The venting cannula (3) is closed by closing auxiliary head jaws.

Abstract: A method for producing at least one structure (13) by laser action on at least one wall part (11) of a container wall (29) of a product, preferably a plastics container product (1) produced by a blow-molding, filling and sealing method. The particular structure (13) is introduced by the laser action, at least with the laser power, the period of action of the laser, the type of plastics material and the type of desired structure being taken into account, as a linear depression (17) in the one wall part (11). The depression (17) is delimited at the edge and in a manner following the profile of the linear depression (17) by in each case one elevation (27) brought about under the influence of the intrinsic material stress of the plastics material.

Abstract: A device minimizes the oxygen content in containers provided with a displacement medium or fluid by a feed unit (20). The displacement medium displaces oxygen from the container before closing. The food device (20) has one medium feed channel to introduce the displacement medium into the container and being at least partially a component of a filling device (26) for filling the container. The filling device (26) has a filling mandrel (17) with a filling channel (28), from which the media feed channel extends in a separated manner. The filling mandrel (17) has at least one further medium transport channel. The filling channel (28) is guided at its free cross-section in a ring channel region of the filling mandrel (17) having a larger cross-section. The filling channel (28) separates the medium feed channel from the medium transport channel within the ring channel region in a fluid-tight manner.

Abstract: The invention relates to a method for producing an applicator for applying liquid or pasty media (1), comprising a container (3), which stores the medium (1) in question, road an application element (5, 13), which is attached to the container (3) in a usage position in such a way that the application element provides the medium (1) outside the container (3) by capillary action for the application characterized by the following steps: creating a hose made of thermoplastic plastic by extrusion and inserting the hose into a mold, forming a container (3) closed at the bottom by expanding the hose in the mold, at least partially tiling the container (3) located in the mold with the medium (1) in question separating the container (3) from the hose in order to form an opening accessible at the top side of the container (3), putting the application element (5, 13) into the usage position thereof by at least partially inserting the application element through the opening of the hose, and fastening the application elem

Abstract: An apparatus for producing at least one container, in particular in ampoule form, made of thermoplastic material, includes a mold (13) with mold components (15, 17). A first calibrating mandrel (19) and a second calibrating mandrel (23) are movable coaxially in relation to the longitudinal direction (21) of the container (1) and in relation to one another. The first calibrating mandrel (19) through the container (1) located in the mold (13) and the second calibrating mandrel (23) from the outer side of the container (1), move into a shaping position in which they calibrate a bottom area that forms at least part of a container bottom between the mandrel ends. A severing device has a movable cutting or punching surface (37) to sever excess plastic material forming during the shaping process in interaction with a cutting or bearing edge on the mold components (17) assigned to the bottom region.

Abstract: A cleaning machine for containers, containing a housing in which various treatment stations, including a feed station and a discharge station, are accommodated, whereby the housing has two side walls located opposite each other. In order to simplify the installation of the cleaning machine, a modular construction is used, whereby at least the discharge station is formed as a module.

Abstract: A method for producing at least one structure (13) by way of laser action on at least one wall part (11) of a container wall (29) of a product, preferably a plastics container product (1) produced by a blow-moulding, filling and sealing method, is characterized in that the particular structure (13) is introduced by means of the laser action, at least with the laser power, the period of action of the laser, the type of plastics material and the type of desired structure being taken into account, as a linear depression (17) in the one wall part (11), such that said depression (17) is delimited at the edge and in a manner following the profile of the linear depression (17) by in each case one elevation (27) which is brought about under the influence of the intrinsic material stress of the plastics material.

Abstract: A device for filling containers includes an arrangement (7) for feeding filling material to at least one dosing system (5) forming a flow path (27) containing a dosing valve (29) that can be opened at least for the duration of the dosing processes to distribute the dosing amounts of the filling material via at least one filling line (9) into relevant containers. The dosing system (5) has an element (31, 33, 43) disposed in the flow path (27) downstream of the dosing valve (29) for selectively producing a suction effect in the flow path (27). A control mechanism (39) activates the element (31, 33, 43) producing the suction effect. Dosing processes are completed by closing the dosing valve (29).

Abstract: A separating device for cutting off individual containers (12) from a frame network made of a plastic material, particularly of polypropylene, has at least one punching device at least partially separating the containers (12) from a waste frame. Because the punching device can be moved by a ball screw drive (46) that can be driven by a drive unit, particularly in the form of an eclectic motor (48), along a punching axis (44) from a starting position to a punching position and back again, the separation can be done at high speed, determined by the screw shaft that can be driven by the electric motor.

Abstract: A method for cleaning containers, in particular bottles of glass or plastics, and a cleaning machine with at least one cleaning medium, with the containers cleaned at least in one station preferential for the cleaning result and/or in a procedure step with at least essentially chemical-free cleaning media. The cleaning medium is advantageously a granular material, in particular granular ice, carried under pressure with compressed air or compressed water. The cleaning machine suited for carrying out the method includes downstream of an unpacking and presoaking station, a pre-cleaning station with a high pressure water blasting pre-cleaning section, and subsequently an intensive cleaning station with at least one intensive cleaning section to which a pressure blasting system for chemical-free, granular material and a carrier medium are associated, and a disinfection station following the intensive cleaning station.

Abstract: An apparatus for conditioning plastic containers for putting them into use, in particular ampoules (13), formed into container blocks (11) side by side next to separating lines (17) at which the containers (13) can be separated from one another for use. A pre-separating station (13) is provided, into which the container blocks (11) can be moved in conveying steps and in which a swinging blade (27) is provided for each of the separating lines (17). The swinging blades (27) are coupled to a common drive (31, 33) for a cutting stroke to produce pre-separating incisions at the separating lines (17) such the cutting strokes of each swinging blade (27) takes place in a sequence offset in time in relation to the cutting strokes of other cutting blades (27).

Abstract: A receptacle of an elastically flexible plastic includes a dosing chamber (10) with a medium to be discharged. One end of the dosing chamber (10) has a discharge opening (18). The opposite end is connected via a junction point (20) to a compressible receptacle part (22) with a gaseous propelling medium. When compressing the receptacle part (22), the propelling medium forces the medium to be discharged out of the dosing chamber (10) via the discharge opening (18). The junction point (20) between the dosing chamber (10) and the receptacle part (22) is a bottleneck creating a capillary effect independent of the spatial position of the receptacle preventing transfer of the medium of the dosing chamber (10) into the receptacle part (22).