Patents by Inventor Bette T. Korber

Bette T. Korber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising HIV envelopes to induce CH235 lineage antibodies
    Patent number: 11884704
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: January 30, 2024
    Assignees: DUKE UNIVERSITY, TRIAD NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin O. Saunders
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE HIV-1 ANTIBODIES
    Publication number: 20230382952
    Abstract: The invention is directed to modified HIV-1 envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-1 envelopes and/or these nucleic acids to induce immune responses.
    Type: Application
    Filed: October 19, 2021
    Publication date: November 30, 2023
    Inventors: Kevin O. SAUNDERS, Barton F. HAYNES, Bette T. KORBER, Kshitij G. WAGH
  • COMPOSITIONS COMPRISING V2 OPT HIV ENVELOPES
    Publication number: 20220380412
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelopes with optimized V2 loop for antibody induction.
    Type: Application
    Filed: October 23, 2020
    Publication date: December 1, 2022
    Inventors: Kevin O. SAUNDERS, Barton F. HAYNES, Bette T. KORBER, Kshitij G. WAGH, Beatrice H. HAHN, Ronnie M. RUSSELL
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 11331386
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: May 17, 2022
    Assignees: Beth Israel Deaconess Medical Center, Inc., Triad National Security, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Compositions and methods for inducing HIV-1 antibodies
    Patent number: 11246920
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there—from, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: February 15, 2022
    Assignees: Duke University, Triad National Security, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Bette T. Korber, Peter T. Hraber, Kevin Saunders
  • Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same
    Patent number: 11230572
    Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: January 25, 2022
    Assignees: Beth Israel Deaconess Medical Center, Inc., Triad National Security, LLC
    Inventors: Dan H. Barouch, Christine Bricault, Bette T. Korber, Karina Yusim
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE CH235 LINEAGE ANTIBODIES
    Publication number: 20210277065
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 11, 2021
    Publication date: September 9, 2021
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER, Kevin O. SAUNDERS
  • COMPOSITIONS AND METHODS FOR INDUCING HIV-1 ANTIBODIES
    Publication number: 20210187091
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 24, 2021
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Bette T. KORBER, Peter T. HRABER, Kevin SAUNDERS
  • Compositions comprising HIV envelopes to induce CH235 lineage antibodies
    Patent number: 10968255
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 6, 2021
    Assignees: Duke University, Triad National Security, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin Saunders
  • Consensus/ancestral immunogens
    Patent number: 10946090
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 16, 2021
    Assignees: Duke University, The University of Alabama at Birmingham Research Foundation, Triad National Security, LLC
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise L. Monti, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS
    Publication number: 20210052720
    Abstract: The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
    Type: Application
    Filed: April 29, 2020
    Publication date: February 25, 2021
    Inventors: Barton F. Haynes, Bette T. Korber
  • Methods of inducing an immune response against HIV-1 using recombinant envelopes with improved coverage
    Patent number: 10906941
    Abstract: The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: February 2, 2021
    Inventors: Jerome Kim, Morgane Rolland, Bette T. Korber, Barton F. Haynes
  • ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
    Publication number: 20200397890
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 24, 2020
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Antibody evolution immunogens
    Patent number: 10849970
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 1, 2020
    Assignees: Duke University, Triad National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The Government of The United States of America as Represented by the Secretary of the Department of Health and Human Services, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John R. Mascola
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 10772952
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: September 15, 2020
    Assignees: Beth Israel Deaconess Medical Center, Inc., Triad National Security, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • SIGNATURE-BASED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING THE SAME
    Publication number: 20200055901
    Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Application
    Filed: October 17, 2017
    Publication date: February 20, 2020
    Inventors: Dan H. BAROUCH, Christine BRICAULT, Bette T. KORBER, Karina YUSIM
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE CH235 LINEAGE ANTIBODIES
    Publication number: 20200002383
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 1, 2017
    Publication date: January 2, 2020
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER, Kevin SAUNDERS
  • ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
    Publication number: 20190314492
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 17, 2019
    Inventors: Dan H. BAROUCH, Bette T. KORBER, William M. FISCHER
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 10426831
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 1, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., TRIAD NATIONAL SECURITY, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Compositions comprising CH848 envelopes and uses thereof
    Patent number: 10322141
    Abstract: In certain aspects the invention provides immunogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: June 18, 2019
    Assignees: DUKE UNIVERSITY, TRIAD NATIONAL SECURITY, LLC, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Barton F. Haynes, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, Peter T. Hraber