Patents by Inventor Bette T. Korber

Bette T. Korber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding mosaic HIV-1 gag proteins
    Patent number: 9492532
    Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 15, 2016
    Assignees: DUKE UNIVERSITY, U. OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, BETH ISRAEL DEACONESS MEDICAL CENTER, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS
    Publication number: 20160317648
    Abstract: The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
    Type: Application
    Filed: December 18, 2014
    Publication date: November 3, 2016
    Inventors: Barton F. HAYNES, Bette T. KORBER
  • POLYVALENT HIV-1 IMMUNOGEN
    Publication number: 20160115205
    Abstract: The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
    Type: Application
    Filed: April 15, 2014
    Publication date: April 28, 2016
    Inventors: Jerome Kim, Morgane Rolland, Bette T. Korber, Barton F. Haynes
  • POLYVALENT VACCINE
    Publication number: 20160067329
    Abstract: The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Application
    Filed: April 17, 2015
    Publication date: March 10, 2016
    Inventors: Bette T. KORBER, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
    Publication number: 20160024156
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 28, 2016
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • ANTIBODY EVOLUTION IMMUNOGENS
    Publication number: 20150366961
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Application
    Filed: September 12, 2013
    Publication date: December 24, 2015
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Rebecca M. LYNCH, Tongqing ZHOU, Feng GAO, Scott BOYD, George M. SHAW, Beatrice H. HAHN, Thomas B. KEPLER, Bette T. KORBER, Peter KWONG, John MASCOLA
  • POLYVALENT VACCINE
    Publication number: 20150359875
    Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.
    Type: Application
    Filed: April 17, 2015
    Publication date: December 17, 2015
    Inventors: Bette T. KORBER, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • POLYVALENT VACCINE
    Publication number: 20150265700
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: May 29, 2015
    Publication date: September 24, 2015
    Inventors: Bette T. KORBER, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
    Patent number: 9044445
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine containing nucleic acids encoding HIV-1 gag mosaic proteins, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: June 2, 2015
    Assignees: LOS ALAMOS NATIONAL SECURITY, LLC, BETH ISRAEL DEACONESS MEDICAL CENTER, DUKE UNIERSITY, THE UAB RESEARCH FOUNDATION
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 9017691
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: April 28, 2015
    Assignees: Beth Israel Deaconess Medical Center, Los Alamos National Security, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
    Patent number: 9011873
    Abstract: The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: April 21, 2015
    Assignees: Los Alamos National Security, LLC, Duke University, Beth Israel Deaconess Medical Center, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • Human immunodeficiency virus type 1 clade M mosaic gag polypeptides
    Patent number: 9011875
    Abstract: The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: April 21, 2015
    Assignees: Los Alamos National Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • POLYVALENT IMMUNOGEN
    Publication number: 20130273103
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to polyvalent immunogens suitable for use in inducing an immune response to HIV-1 in a patient, and to methods of identifying such immunogens. The invention further relates to methods of inducing an anti-HIV-1 immune response using such immunogens.
    Type: Application
    Filed: September 28, 2011
    Publication date: October 17, 2013
    Applicants: LOS ALAMOS NATIONAL SECURITY, LLC, DUKE UNIVERSITY
    Inventors: Hua-xin Liao, Alan S. Lapedes, Barton F. Haynes, Bette T. Korber
  • POLYVALENT VACCINE
    Publication number: 20120231028
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: February 17, 2012
    Publication date: September 13, 2012
    Applicants: Los Alamos National Security, LLC, The University of Alabama at Birmingham Research Foundation, Duke University, Beth Israel Deaconess Medical Center
    Inventors: Bette T. KORBER, Simon PERKINS, Tanmoy BHATTACHARYA, William M. FISCHER, James THEILER, Norman LETVIN, Barton F. HAYNES, Beatrice H. HAHN, Karina YUSIM, Carla KUIKEN
  • POLYVALENT VACCINE
    Publication number: 20120121631
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: August 14, 2009
    Publication date: May 17, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Consensus/ancestral immunogens
    Publication number: 20120087938
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Application
    Filed: August 23, 2011
    Publication date: April 12, 2012
    Applicants: DUKE UNIVERSITY, THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
    Publication number: 20120076812
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 29, 2012
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
    Patent number: 8119140
    Abstract: The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: February 21, 2012
    Assignees: Los Alamos Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • POLYVALENT VACCINE
    Publication number: 20110301328
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: April 26, 2011
    Publication date: December 8, 2011
    Applicants: Los Alamos National Security, LLC, The University of Alabama at Birmingham Research Foundation, Beth Israel Deaconess Medical Center, Duke University
    Inventors: Bette T. KORBER, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins
    Patent number: 8071107
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: December 6, 2011
    Assignees: Duke University, The Regents of the University of California, The University of Alabama at Birmingham Research Foundation
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao