Patents by Inventor Bette T. Korber

Bette T. Korber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising CH505 envelopes, and trimers
    Patent number: 10232034
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: March 19, 2019
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber
  • ANTIBODY EVOLUTION IMMUNOGENS
    Publication number: 20180360948
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Application
    Filed: January 8, 2018
    Publication date: December 20, 2018
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Rebecca M. LYNCH, Tongqing ZHOU, Feng GAO, Scott BOYD, George M. SHAW, Beatrice H. HAHN, Thomas B. KEPLER, Bette T. KORBER, Peter KWONG, John R. MASCOLA
  • Swarm immunization with envelopes from CH505
    Patent number: 10149902
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: December 11, 2018
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Peter T. Hraber
  • CONSENSUS/ANCESTRAL IMMUNOGENS
    Publication number: 20180296665
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Application
    Filed: November 15, 2017
    Publication date: October 18, 2018
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS (EIGHT VALENT HIV-1 COMPOSITION AND METHODS)
    Publication number: 20180271973
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens in vaccination to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens and methods of using these comprise an immune modulating component.
    Type: Application
    Filed: December 23, 2015
    Publication date: September 27, 2018
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER
  • MPER-liposome conjugates and uses thereof
    Patent number: 10076567
    Abstract: The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: September 18, 2018
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Bette T. Korber, S. Munir Alam
  • POLYVALENT VACCINE
    Publication number: 20180185471
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: December 15, 2017
    Publication date: July 5, 2018
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Antibody evolution immunogens
    Patent number: 10004800
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: June 26, 2018
    Assignees: Duke University, Los Alamos National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John Mascola
  • Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
    Patent number: 9844590
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 19, 2017
    Assignees: Duke University, Los Alamos National Security, LLC, Beth Israel Deconess Medical Center, The UAB Research Foundation
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins capable of inducing broadly reactive T- and B-cell responses
    Patent number: 9844589
    Abstract: The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: December 19, 2017
    Assignees: DUKE UNIVERSITY, THE UNIVERSITY OF ALABAMA BIRMINGHAM RESEARCH FOUNDATION, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins
    Patent number: 9821053
    Abstract: The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 21, 2017
    Assignees: Duke University, Los Alamos National Security, LLC, The UAB Research Foundation, Beth Israel Deaconess Medical Center
    Inventors: Bette T. Korber, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • SWARM IMMUNIZATION WITH 54 ENVELOPES FROM CH505
    Publication number: 20170326229
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swami immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: September 29, 2015
    Publication date: November 16, 2017
    Inventors: Barton F. HAYNES, Bette T. KORBER, Peter T. HRABER, Hua-Xin LIAO
  • HIV Vaccines Comprising One or More Population Episensus Antigens
    Publication number: 20170319679
    Abstract: Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.
    Type: Application
    Filed: October 5, 2015
    Publication date: November 9, 2017
    Applicant: Vir Biotechnology, Inc.
    Inventors: Eric E. BRUENING, Klaus FRUEH, Louis PICKER, Bette T. KORBER, James THEILER, Emily MARSHALL
  • COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF
    Publication number: 20170312303
    Abstract: In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
    Type: Application
    Filed: March 31, 2015
    Publication date: November 2, 2017
    Inventors: Barton F. HAYNES, Beatrice H. HAHN, George M. SHAW, Bette T. KORBER, Peter T. HRABER
  • COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS
    Publication number: 20170281749
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
    Type: Application
    Filed: September 25, 2015
    Publication date: October 5, 2017
    Applicants: Duke University, Los Alamos National Security, LLC
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER
  • ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
    Publication number: 20170239344
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Application
    Filed: April 17, 2017
    Publication date: August 24, 2017
    Inventors: Dan H. BAROUCH, Bette T. KORBER, William M. FISCHER
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 9670253
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: June 6, 2017
    Assignees: Beth Israel Deaconess Medical Center, Inc., Los Alamos National Security, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • MOSAIC HIV-1 SEQUENCES AND USES THEREOF
    Publication number: 20170107260
    Abstract: The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.
    Type: Application
    Filed: March 25, 2015
    Publication date: April 20, 2017
    Inventors: Barton F. Haynes, Bette T. Korber
  • SWARM IMMUNIZATION WITH ENVELOPES FROM CH505
    Publication number: 20170080082
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: Barton F. HAYNES, Feng GAO, Bette T. KORBER, Peter T. HRABER
  • MPER-LIPOSOME CONJUGATES AND USES THEREOF
    Publication number: 20170014503
    Abstract: The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 19, 2017
    Inventors: Barton F. HAYNES, Bette T. KORBER, S. Munir ALAM