Abstract: Aerosol formulations of granisetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: Memory devices, methods and systems are described in which a non-transitory memory device stores instructions that, when executed by a processor, cause the processor to: receive, via an input component, at least one message from a network element in a multi-layer network comprising information indicative of at least one failure of a working path; determine based at least in part on information indicative of a data transport path coincident with the working path in a second layer in the network different from the first layer, an alternate path in the first layer for transmission of the data through the multi-layer network; and transmit, via an output component, at least one signal comprising configuration instructions to at least one line module, the configuration instructions directing the line module to switch and transmit the data using the alternate path.

Abstract: A 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine are provided. Specifically, a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and use thereof as a therapeutic agent, in particular as an A2a or A2b receptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the A2a or A2b receptor are provided. Each substituent in general formula (I) is defined in the description.

Abstract: A method, comprises measuring, by circuitry of a computer system, a first bandwidth of data traffic of a transport path over a time period, the transport path passing through a plurality of nodes and conforming to a protocol using a number of time slots to allocate a second bandwidth to the transport path. The method further includes passing a signal, from the computer system to at least one of the nodes of the transport path, the signal including at least one instruction that when executed by circuitry of the at least one node causes a change to the number of time slots allocated to the transport path.

Abstract: A method and node are disclosed. In the method, circuitry of a first node generates a link state advertising message including bandwidth information indicative of unreserved number of optical channel data unit containers for a plurality of different types of signals supported by an interface of the first node. The link state advertising message is transmitted from the first node to a plurality of second nodes within a mesh network.

Abstract: Vesicular stomatitis virus glycoprotein (VSVG) can both load protein cargo onto exosomes and increase their delivery ability via a pseudotyping mechanism. By fusing a set of fluorescent and luminescent reporters with VSVG, we show the successful targeting and incorporation of VSVG fusions into exosomes by gene transfection and fluorescence tracking. VSVG pseudotyping of exosomes does not affect the size or distributions of the exosomes, and both the full-length VSVG and the VSVG without the ectodomain integrate into the exosomal membrane, suggesting that the ectodomain is not required for protein loading. Finally, exosomes pseudotyped with full-length VSVG are internalized by multiple-recipient cell types to a greater degree compared to exosomes loaded with VSVG without the ectodomain, confirming a role of the ectodomain in cell tropism.

Abstract: Methods, nodes and control modules are disclosed. In the method, circuitry of a first node in a mesh network converts an optical layer in a working path between the first node and a second node, to a data stream in a digital layer. The working path carries data traffic from the first node to the second node in the optical layer of the mesh network when there is no failure in the working path. Circuitry of the first node in the mesh network detects a failure in the working path due to detection of an error in the data stream in the digital layer. The circuitry of the first node establishes, through transmission of at least one signal from the first node to the second node, a restoration path in the optical layer based on, at least in part, detection of the error in the data stream in the digital layer.

Abstract: The present invention relates to a benzofuran derivative, a preparation method thereof and a use thereof in medicine. In particular, the present invention relates to the benzofuran derivative as shown by general formula (I), the preparation method thereof, a pharmaceutical composition containing the derivative, and uses thereof as an EZH2 inhibitor and in the prevention and/or treatment of diseases such as tumours and cancers, etc., and in particular, uses thereof in the prevention and/or treatment of non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, follicular lymphoma and synovial sarcoma, wherein the definitions of the substituents in the general formula (I) are the same as those defined in the description.

Abstract: The present disclosure provides for palonosetron formulations, such as aerosol formulations of palonosetron for pulmonary delivery. Also provided are uses of the formulation, such as reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, or surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: Methods and systems are disclosed for storing, in a non-transitory memory device, multi-layer network information comprising at least one of link availability, bandwidth availability, priority levels for paths in a multi-layer network, path status in the multi-layer network, and status for network elements in the multi-layer network; receiving, via at least one input component, a message from a network element in the network comprising information indicative of a failure of a working path in the network; determining, automatically, based at least in part on the multi-layer network information, an alternate path for transmission of the data traffic through the network; and transmitting, via at least one output component, at least one signal comprising configuration instructions to at least one optical line module, the configuration instructions directing the optical line module to switch and select the data traffic using the alternate path.

Abstract: Systems and methods for a multi-layer network to achieve network resource isolation among clients using the same server network, such as a VPN in a multi-layered network and interaction within the node, may include interaction between a server layer (e.g. L0 Photonic network) and the client layer (e.g. L1 network) that help the client layer (L1) gather information about the server-layer (L0) connection affinities. For example, the use of server layer (L0) connection affinities to construct Virtual Network Topologies (VNT) and/or network abstractions for customer traffic isolations in client layer (L1), the use of VNT to offer physical and/or logical network resource isolation for L1 customers, and provide L1 VPN services in a multi-layer environment.

Abstract: Aerosol formulations of granisetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: Engineered exosomes for the delivery of bioactive cargo are provided. The exosomes incorporate a tetraspanin transmembrane anchoring scaffold onto the membrane of the exosome. The tetraspanin transmembrane anchoring scaffold has a C-terminal attachment site in the inner-vesicle space of the exosome, a N-terminal attachment site in the inner-vesicle space or the outer-vesicle space, and/or a loop attachment site in the outer-vesicle space. Peptides can be attached to the different attachments sites in any form or combination. Tetrapanins naturally anchor on the exosome membrane, are biocompatible, and allow for robust loading and delivery of bioactive cargos in mammalian system.

Abstract: A network device may receive an activation instruction. The network device may provide network resources. The activation instruction may request the network device to activate a particular network resource that is deactivated. The activation instruction may be associated with a license that identifies the particular network resource and identifies a resource request of a user. The network device may configure, based on the activation instruction, a component of the network device to activate the particular network resource. The component, after being configured to activate the particular network resource, may allow data flows, received by the network device, to be provided towards a destination device using the particular network resource. The network device may receive a data flow and provide, by the component of the network device, the data flow towards the destination device using the particular network resource.

Abstract: Aerosol formulations of granisetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: Aerosol formulations of ondansetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: A method for receiving, by circuitry of an optical node adapted for wavelength multiplexing and wavelength switching, over an OSC an optical signal comprising overhead information indicative of status of at least one of an optical layer in an OTN; terminating the optical signal; notifying software of the status of the optical layer; detecting, based on the status of the optical layer, a uni-directional or bi-directional failure of a working path between the optical node and a second optical node, wherein the working path carries data traffic from the first optical node to the second optical node in the OTN when there is no failure in the working path; and switching, triggered by the uni-directional or bi-directional failure of the working path, to select the data traffic from a protection path, wherein the protection path carries data traffic between the optical node and the second optical node.

Abstract: A switch node provided with a switch, an input interface and an output interface. The input interface is adapted to couple to a first communication link to receive a first TDM frame having a user payload field containing a first user data from the first communication link, and a frame overhead field containing a first identification. The input interface is configured to validate the first identification in the frame overhead field and reject the first TDM frame responsive to the first identification being invalid, and to forward the first user data to the switch responsive to the first identification being valid. The output interface is adapted to couple to a second communication link. The output interface is configured to receive the first user data from the switch, and to generate a second TDM frame having a second user payload field containing the first user data, and a second frame overhead field containing a second identification that is different from the first identification.

Abstract: Embodiments herein include methods and apparatuses for providing optical channel protection by a switching controller in an optical networking system. The switching controller may receive, from a light module, a digital fault status message that indicates whether a digital frame demodulated from an optical signal include a fault. The switching controller may receive from an Optical Supervisory Channel (OSC) module, an Optical Layer Defect Propagation (OLDP) status message that indicates an OSC status of the optical signal on a current optical path. The switching controller may receive, from an Optical Add Drop Multiplexer (OADM) module, an optical power status message that indicates a measured power level of the optical signal on the optical path. Based on at least one of the OLDP status, the optical power status, or the digital fault status message, the switching controller may determine the optical path as a working path or a protecting path.

Abstract: A method, performed in a network that includes a group of nodes, includes identifying a path through a set of the nodes, where each node, in the set of nodes, has a data plane and a control plane; establishing a control plane tunnel, associated with the path, within the control plane of the nodes in the set of nodes; establishing a data plane tunnel, associated with the path, within the data plane of the nodes in the set of nodes, where the data plane tunnel is associated with the control plane tunnel and established through the same set of nodes; and transmitting a control message through the control plane tunnel to change a state of the data plane tunnel.