Abstract: The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: A method for preparing high-content conjugated linoleic acid (CLA) through Purification of vegetable oil includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing corresponding methyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-based silica gel column chromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.

Abstract: The present invention relates to a fixed bed decolorization process for an polyunsaturated fatty acid, comprising a polyunsaturated fatty acid or a polyunsaturated fatty acid solution is either passed directly through a filler of the fixed bed or recycled in a filler of the fixed bed, a colorless or light-colored polyunsaturated fatty acid product is ultimately produced, at the same time, other than the color, other qualities of the polyunsaturated fatty acid remain unaffected. The decolorization process allows continuous operation or intermittent operation. The filler of the fixed bed comprises one or a mixture of activated carbon, diatomite, carclazyte, silicone and an ion-exchange resin. An upper or a middle or a bottom or a combination thereof is employed to feed a polyunsaturated fatty acid feedstock or a polyunsaturated fatty acid solution. The filler in the fixed bed can be used repeatedly.

Abstract: Apparatus and methods for controlling voltage converter are provided, in an example, a switched-mode DC-DC voltage converter can include an inductor, at least four switches coupled to the inductor and configured to direct current through the inductor to provide a desired output voltage at an output voltage terminal of the voltage converter using an input voltage supply and a ground reference of the converter, and a controller circuit, configured to receive an indication of inductor current through the inductor and to use the slope of the inductor current to control a change between two operating modes of a group of operating modes that include a boost operating mode, a buck operating mode, and a buck-boost operating mode.

Abstract: The present disclosure provides pyrimidines of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, G, Y, n, R2a, R2b, and R3 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat a disorder responsive to the blockade of one or more sodium channels. In one embodiment, compounds of the present disclosure are useful for treating pain.

Abstract: The present invention discloses a method for recycling urea in the process of separating and purifying unsaturated substances through a urea adduction method. The method comprises the following steps: liposoluble substances containing target unsaturated components are used as raw materials, and subjected to urea adduction, crystallization and filtration to produce a filtrate, from which the specific unsaturated components are obtained; the urea adduct is dissolved in a polar solvent, and after the adducted adducts are layered and released, adding a certain solvent to the urea solution to adjust the polarity, then cooling for crystallization, and recycling the urea.

Abstract: The present invention relates to a preparation method for a polyunsaturated fatty acid-calcium, primarily comprising directly reacting a polyunsaturated fatty acid material with a water-soluble calcium compound to obtain a polyunsaturated fatty acid-calcium salt. The present invention has a simple technical process, short reaction time, and high reaction yield. The produced polyunsaturated fatty acid-calcium product is of high quality, and relatively less byproducts and waste water are produced. The process is overall environmentally friendly and has small safety risks, and is suitable for scaled production.

Abstract: The present invention relates to a method for preparing glyceride type polyunsaturated fatty acids. The method comprises: firstly mixing a basic catalyst with glycerol or a glyceride uniformly; then adding the mixture to a polyunsaturated fatty acid material slowly, and carrying out an esterification reaction under certain conditions to obtain glyceride type polyunsaturated fatty acids, wherein the basic catalyst is a lower aliphatic alcohol sodium/potassium or a solution thereof. The procedure of the process is simple, has mild reaction conditions, short reaction time, high yield and good quality of the obtained product.

Abstract: The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: Apparatus and techniques described herein can include a load circuit comprising a direct current (DC) input terminal, and a source circuit comprising a direct current (DC) output terminal coupled to the DC input terminal of the load circuit. The source circuit can include a source control circuit configured to provide a current-limited DC output voltage and monitor the current-limited DC output voltage to detect an authentication signal provided at the DC output terminal by the load circuit, the load circuit configured to modulate the voltage at the DC output terminal using a pull-down circuit. The load circuit can be configured to compare the supply voltage at the DC input terminal to a reference voltage and, in response, energize other portions of the load circuit when the input current provided the DC input terminal is sufficient as indicated at least in part by the comparison.

Abstract: At least one embodiment provides a method for a nanopower boost regulator to startup from an ultra-low-voltage (such as 0.3V˜0.5V) for energy harvesting applications. The method does not necessarily require a special process or any external components such as mechanical switches. The startup circuit can include an asynchronous boost circuit to charge up an output with stacked power NMOS transistors, a ring oscillator, and/or a charge pump, along with accompanying circuitry.

Abstract: An electronic circuit can be coupled to an energy harvesting device. The output of the energy harvesting device can provide a damped oscillating waveform elicited from a transient stimulus applied to the energy harvesting device, such as in response to mechanical shock or mechanical impact excitation. A first switch can be coupled between the energy harvesting device and an inductor and configured to selectively connect the input node to the inductor. A second switch can be coupled between the inductor and an energy storage device, the second switch configured to selectively couple the inductor to the energy storage device. A control circuit can be coupled to the first and second switches, such as configured to operate the first and second switches according to one or more of an over bias flip technique, a half bias flip technique, or a bias flip technique.

Abstract: The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

Abstract: The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: Apparatus and techniques described herein can include using an electronic circuit comprising a rectifier circuit, an open-circuit voltage (OCV) sampling circuit coupled to the output of the rectifier circuit, and a regulator circuit coupled to the output of the rectifier circuit. In an example, an isolation switch can be located between the regulator circuit and the rectifier circuit, the isolation switch configured to isolate the regulator circuit from the rectifier circuit for sampling of the open-circuit voltage by the open-circuit voltage sampling circuit. In another example, a buffer circuit can be used, such as placed in-line with a divider circuit between a divider circuit and an open-circuit voltage sampling capacitor. In this manner, the buffer circuit can provide a low output impedance, isolating the voltage sampling capacitor from the divider circuit.

Abstract: A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5 ?m. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.

Abstract: The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

Abstract: An active voltage divider circuit is provided comprising: a first node; a second node; a third node; multiple FET load devices coupled in series between the first node and the second node; multiple first switches, each associated with a different FET load device and configured to selectably couple a respective associated bypass circuit between source and drain of its associated FET load device; and second switch circuitry configured to selectably couple a drain of a FET load device, from among the multiple FET load devices, to the third node.

Abstract: The present disclosure provides pyrimidine diol amides of Formula (I), and the pharmaceutically acceptable solvates and prodrugs thereof, wherein A1, X, A2, W1, W2, W3, R1, R2, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.