Abstract: A switching regulator or other apparatus or techniques can include load current monitoring to provide a digital representation of an estimated load current. Load current monitoring can be performed by a circuit including a counter circuit, a comparator circuit, and a digitally-controlled source coupled to the counter circuit and configured to adjust a bias condition of a sensing device in response to a count provided by the counter circuit in order to establish a proportional relationship between a current conducted by the sensing device and a corresponding current conducted by a power switching device. The counter circuit is configured to increment and decrement the count in response to information provided by the comparator output and the count is generally indicative of the estimated load current, such as an average load current.

Abstract: In one aspect, this disclosure relates to a method of controlling current output from a switching regulator to a load via an inductor. Inductor current information can be sampled at a peak level, such as just before a transistor configured to cause current to flow through the inductor is turned off. The sampled inductor current can be compared with a reference current, and a current limit threshold can be adjusted based on the comparison. The output current of the switching regulator can be controlled based on a comparison of the current limit threshold with an indicator of current flowing through the inductor. This method can accurately and efficiently limit current in a switching regulator.

Abstract: A device to detect an electrical signal is provided. The device includes sensing, output, and pull-down nodes. The device includes a pull-down circuit having a native metal-oxide-semiconductor field-effect transistor (MOSFET) to pull down the output node to approximately a voltage of the pull-down node. The device includes a switch circuit having a junction field-effect transistor (JFET). The JFET turns on the pull-down circuit in response to a voltage of the sensing node being less than a first threshold. The JFET also turns off the pull-down circuit in response to the voltage of the sensing node being greater than the first threshold.

Abstract: The present disclosure provides pyrimidine diol amides of Formula (I), and the pharmaceutically acceptable solvates and prodrugs thereof, wherein A1, X, A2, W1, W2, W3, R1, R2, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: The invention relates to compounds of Formula I: wherein Ar1, Ar2, Ar3, L1, L2, Y, Z and v are defined in the specification, and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof.

Abstract: An apparatus comprises an output port for a circuit load, a first input port for an energy harvest source, an input/output port a second energy source, a first circuit path from the energy harvest source to the second energy source at the input/output port and to the variable load at the output port, a second circuit path from the second energy source to the output port, a cold start circuit that produces a first voltage level at the output port by charging a capacitor at the output port using energy of the energy harvest source, and a main converter circuit that produces a second regulated voltage level at the input/output port using energy of the energy harvest source when the voltage at the output port capacitor is above a specified voltage value and uses the energy of the capacitor at the output port during startup of the main converter circuit.

Abstract: The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

Abstract: The present disclosure provides pyrimidine diol amides of Formula (I), and the pharmaceutically acceptable solvates and prodrugs thereof, wherein A1, X, A2, W1, W2, W3, R1, R2, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

Abstract: An apparatus comprises a switching power circuit and a control circuit. The switching power converter circuit includes an output port for electrical coupling to a variable load, an input port for electrically coupling to a first energy source, wherein the energy density of the first energy source is insufficient to meet a peak energy requirement of the variable load, an input/output port for electrical coupling to a second energy source, and one inductor electrically coupled to the input port and a circuit node, wherein the electrical coupling is non-switchable. The control circuit is configured to charge the inductor using the first energy source via the input port, to provide energy from the inductor to the load via the output port, and to provide both of, via the input/output port, energy from the inductor to the second energy source and energy from the second energy source to the variable load.

Abstract: A device to sense voltage is provided. The device includes a first circuit operatively coupled to one or more nodes. The first circuit senses an electrical characteristic of each of the one or more nodes. The first circuit generates an adjustment signal based on the electrical characteristic sensed at each of the one or more nodes. A second circuit operatively receives a first voltage and a second voltage, the second circuit being configured to generate a third voltage by scaling the second voltage. The second circuit generates a comparison signal based on a comparison of the first voltage and the third voltage.

Abstract: This application discusses, among other things apparatus and methods for a voltage boost circuit. In an example, a voltage boost circuit can include first and second inverters, sharing a first supply node, and sharing a second supply node, a first charge transfer capacitor, configured to couple a first clock signal to the first inverter output, a second charge transfer capacitor, configured to couple a second clock signal to the second inverter output, the second clock signal being out-of-phase with the first clock signal, a first gate drive capacitor, configured to couple the first clock signal to the second inverter input, and a second gate drive capacitor, configured to couple the second clock signal to the first inverter input.

Abstract: The invention discloses a method for preparing high-content zeaxanthin. In the conventional preparation methods, some methods adopt certain toxic organic solvents; some methods require the multi-step crystallization process; and some methods are featured by long reaction time, high temperature and lower product yield, thus being not suitable for industrial production. The invention adopts lutein crystal or its fatty acid ester as the raw material and utilizes isomerization reaction to produce zeaxanthin, and is characterized in that a mixed catalyst consisting of an organic base catalyst and a cocatalyst is used in the isomerization reaction, wherein the cocatalyst is palladium carbon. The invention has the advantages of simple process route, low reaction temperature, short reaction time, good product purity and high yield, thus being suitable for industrial production, and no poisonous and harmful organic solvent residues in the product, thus being suitable for the use as a food additive or drug.

Abstract: The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

Abstract: The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

Abstract: Apparatus and techniques for controlling measurement of an electrical parameter of an energy source can be used to obtain information for use in enhancing a power transfer efficiency between the energy source and a load. For example, during a first measurement cycle, information indicative of the electrical parameter of the energy source can be obtained using a measurement circuit during a first sampling duration in which the load is decoupled from the energy source. The information indicative of the obtained electrical parameter can be compared to a threshold. In response to the comparing, a different second sampling duration can be determined for use in obtaining information indicative of the electrical parameter during a subsequent measurement cycle. The information indicative of the electrical parameter of the energy source includes information for use in enhancing the power transfer efficiency between the energy source and the load.

Abstract: A switching regulator or other apparatus or techniques can include load current monitoring to provide a digital representation of an estimated load current. Load current monitoring can be performed by a circuit including a counter circuit, a comparator circuit, and a digitally-controlled source coupled to the counter circuit and configured to adjust a bias condition of a sensing device in response to a count provided by the counter circuit in order to establish a proportional relationship between a current conducted by the sensing device and a corresponding current conducted by a power switching device. The counter circuit is configured to increment and decrement the count in response to information provided by the comparator output and the count is generally indicative of the estimated load current, such as an average load current.

Abstract: Embodiments are directed to processing queries using schema graph traversal and to establishing a schema graph that allows queries to be answered by traversing graph nodes. In one scenario, a computer system receives a query which specifies relational tables and corresponding relationships that are to be retrieved from a relational database. The computer system accesses a schema graph that includes graph nodes representing relational tables, as well as edges that identify relationships between the relational tables. The graph nodes include relational data that was loaded from one storage area (e.g. a non-volatile storage area), and the schema graph is stored in a second storage area (e.g. a volatile storage area). The computer system then traverses the schema graph, beginning at a set of graph nodes and continuing along the edges to other graph nodes until the query has been satisfied, and then reports the results of the graph traversal.

Abstract: The present disclosure proposes a fully integrated accurate LED output current controlling circuit and method, which can be seamlessly combined with true PWM dimming. The current controlling circuit has an auto zero function in the light-emitting diode driver to eliminate offsets caused by the system, process variations, parasitic effects, dimming and so on in an LED driver application, and thus is capable of controlling the LED current with high accuracy. Moreover, the driver of the present disclosure does not require the use of external components such as an external resistor to regulate current accuracy.

Abstract: A method and system to inhibit the switching of a current mode switching converter having high and low side switching elements coupled to an output inductor, the other end of which is coupled to an output node, and operated with respective modulated switching signals to regulate an output voltage Vout produced at the node. A current IC that varies with the difference between a reference voltage and a voltage proportional to Vout is compared with and a current IDETECT—PEAK which varies with the current conducted by the high side switching element; the result of the comparison of IC and IDETECT—PEAK is used to control the regulation of Vout during normal operation. Current IC is also compared with a current IDETECT—VALLEY which varies with the current conducted by the low side switching element. When IDETECT—VALLEY>IC, a ‘skip mode’ is triggered during which the switching signals are inhibited.