Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.

Abstract: Various embodiments are directed to processing and executing digital asset transfers between two users. An example method includes receiving a data object defining a digital asset transfer, and the data object may be a query from the first user to initiate an outbound transfer to a second user or an approval of a request for digital asset units from the second user. The method further includes retrieving account balance data objects associated with the digital asset accounts for the first and second users. The method further includes, responsive to determining that the digital asset transfer satisfies one or more transfer conditions, executing the digital asset transfer by executing a closed-loop debit from the first user and executing a closed-loop credit to the second user. The method further includes updating the account balance data object to reflect the resulting balances of each digital asset account.

Abstract: Systems and methods for tool orientation and/or position determining system are described herein. In one example, a plurality of tool sensors can be coupled to a tool. The tool sensors can provide data to a control module or system controller. The orientation and/or position of the tool can accordingly be determined from the data. If the orientation and/or position of the tool matches a desired orientation, the tool and/or control module can provide an indication that the tool is in the desired orientation.

Abstract: Various embodiments of the present disclosure are generally directed to processing conversions of digital assets to fiat currency. An example method includes obtaining a conversion rate for a digital asset via an API, providing the conversion rate via a client device, receiving a digital asset conversion request and executing a digital asset conversion within a configurable time period. Executing the digital asset conversion includes causing digital asset units to be debited from the digital asset user account and causing fiat currency units to be credited to a fiat currency user account. The method further includes dynamically providing a notification of execution of the digital asset conversion via the client device, updating account balance data objects associated with the digital asset user account and the fiat currency user account, and subsequent to executing the digital asset conversion, executing a fiat currency transaction (e.g., a settlement) with a digital asset exchange system.

Abstract: A system and method for boosting items or news posts in a news feed on an organization news site. A boost module allows an organization communicator or administrator to set boost parameters for a selected news post. The boost parameters may include boosting a news post until it is viewed, boosting for a number of impressions, boosting until a particular date, and setting a rank for the news post relative to other boosted items. Boosting a news post may be done when the news post is created and published or after it has been published. Boosted items or news posts may include an icon or symbol to indicate the item is boosted in the user's newsfeed.

Abstract: Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.

Abstract: Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.

Abstract: A system and method for boosting items or news posts in a news feed on an organization news site. A boost module allows an organization communicator or administrator to set boost parameters for a selected news post. The boost parameters may include boosting a news post until it is viewed, boosting for a number of impressions, boosting until a particular date, and setting a rank for the news post relative to other boosted items. Boosting a news post may be done when the news post is created and published or after it has been published. Boosted items or news posts may include an icon or symbol to indicate the item is boosted in the user's newsfeed.

Abstract: Provided herein are proteins comprising T-cell receptor (TCR) constant domains with one or more stabilization mutations, nucleic acids encoding such proteins, and methods of making and using such proteins.

Abstract: A system for routing commands issued by a passenger of a vehicle to a Smart Home and/or an Internet of Things (IoT) ecosystem via a connection manager. Issued commands are obtained from utterances using speech recognition and analyzed using natural language understanding and natural language processing. Using the output of the natural understanding analysis, the connection manager determines where to send the command by identifying a target Smart Home and/or IoT ecosystem.

Abstract: A system for integrating disparate ecosystems including smart home and internet-of-things (IoT) ecosystems. The system including a vehicle assistant that executes within the context of a cloud-based application and that retrieves sensor data and utterances from a vehicle and forwards the sensor data and passenger-spoken utterances to a cloud-based application. Using the sensor data and utterances, the cloud-based application selects and executes a predetermined routine that includes at least one action to be completed in vehicle, on mobile phone or Smart Home/IoT ecosystem. The action is then complete by issuing the command to the vehicle head-unit, specified mobile phone or target ecosystem selected from a group of disparate ecosystems.

Abstract: A system for building a software application may comprise a database and a hardware processor. The database may be configured to store a plurality of object definitions, each object definition being configured to cause an executing processor to perform specific processing when executed. The hardware processor may be configured to cause a user interface to be displayed; receive, from the user interface, a selection of a plurality of the object definitions and an input specifying at least one relationship between the plurality of the object definitions; create an application definition based on the selection and the input; and provide an application interpreter configured to enable the executing processor to process the application definition. The software application may include the application definition and the application interpreter.

Abstract: A system for building a software application may comprise a database and a hardware processor. The database may be configured to store a plurality of object definitions, each object definition being configured to cause an executing processor to perform specific processing when executed. The hardware processor may be configured to cause a user interface to be displayed; receive, from the user interface, a selection of a plurality of the object definitions and an input specifying at least one relationship between the plurality of the object definitions; create an application definition based on the selection and the input; and provide an application interpreter configured to enable the executing processor to process the application definition. The software application may include the application definition and the application interpreter.

Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.

Abstract: A method of modifying a grain structure of a metal article includes disposing at least a portion of a metal article in a molten salt bath in a pressure vessel. The molten salt bath has bath temperature that is below a melting point temperature of the metal article. The method also includes pressuring the molten salt bath in the pressure vessel to a forging pressure sufficient to cause pressure-driven grain changes in the metal article.

Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.

Abstract: Systems and methods for tool orientation and/or position determining system are described herein. In one example, a plurality of tool sensors can be coupled to a tool. The tool sensors can provide data to a control module or system controller. The orientation and/or position of the tool can accordingly be determined from the data. If the orientation and/or position of the tool matches a desired orientation, the tool and/or control module can provide an indication that the tool is in the desired orientation.

Abstract: In a multi-mask alignment system and method, a carrier frame is provided having a number of apertures therethrough. A number of shadow mask-frame combinations are also provided. Each shadow mask-frame combination includes a first set of alignment features and each shadow mask-frame combination is positioned on a first side of the carrier with the frame supporting the shadow mask in alignment with one of the apertures. A single alignment stage is provided and a control system including a programmed controller is also provided. Under the control of the controller, the single alignment stage translates to each shadow mask-frame combination, one-at-a time, and adjusts the position of the shadow mask-frame combination based on positions of the first set of alignment features determined by the controller.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: The present invention provides methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in CH1/CL interface, Fabs and IgG bi-specific antibodies produced according to said processes as well as nucleic acids, vectors and host cells encoding the same.