Abstract: Disclosed are mutants of protein kinase B/Akt which can be crystallised in an enzymatically active conformation, crystals of these mutants and X-ray coordinate data for the crystals. Also disclosed are methods of using the coordinate data provided for identification of modulators of protein kinase activity and for structural analysis of other protein kinases, in particular AGC kinases.

Abstract: An apparatus for applying stretch film to goods on a pallet. It uses a basic core holder to hold a roll of stretch film which has an adjustable braking mechanism. In addition, the apparatus, which is portable, is ergonomically correct, easy to use, and has a pair of pre-stretch rollers which allow the stretch film to be pulled to increase its elasticity, thereby securing goods effectively on a pallet.

Abstract: A human protein (designated Carboxy-terminal Modulating protein, CTMP) is described and is identified as having tumour suppressor properties. CTMP has been shown to interact with protein kinase B and inhibit protein kinase B activity, establishing its importance in the protein kinase B signalling pathway.

Abstract: A dishwasher rack which includes a basket supporting a plurality of fences rotatably about a common axis. The basket has a plurality of wires forming a bottom wall, a pair of side walls and a front and back wall. The bottom wall has a plurality of upwardly oriented tines connected to and extending from the bottom wall in a first area and further has an open area without upwardly oriented tines. A first fence is provided having an axle wire and a plurality of support wires. The axle wire is rotatably supported adjacent the bottom wall such that the first fence may be rotated between a front position and a back position. A second fence is provided having a connection wire and a plurality of support wires. The connection wire is rotatably connected to axle wire such that the second fence may rotate about the axle wire between a front position and a back position.

Abstract: The invention concerns RAC-PK protein kinase and fragments thereof, as well as activators and inhibitors of RAC-PK protein kinase for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK protein kinase for use in screening potential mimics or modulators thereof. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK.

Abstract: A steel bar 12 is located in a mold. A plug 22 is inserted through the end of the mold to contact a recess in the end of the portion 14 of the bar and plugs 24 are inserted through the sides of the mold into grooves 20. The plugs hold the bar in position whilst carbon fiber is injected around the bar and around portions of pins 26 to fix the pins 26 in relation to the bar.

Abstract: A secure tracking system and method of tracking for articles which are secure and include authentication and verification of users and user devices for data and information access and input. Each article to be tracked is provided with a unique secure indicia applied to the article and through which chronological histories are generated and maintained from creation of each article until at least the time when article is scrapped or otherwise destroyed. The articles can include manufactured components, assemblies, device and equipment for aircraft, automotive, military and other users, as well as jewelry and works of art.

Abstract: The invention concerns a method of modulating the activity of a polypeptide comprising the activating domain of an Ndr family kinase, by influencing the binding of an EF hand-containing calcium binding.

Abstract: A process for preparing compounds of the formula: and intermediates for use in the process.

Abstract: The interaction between PP2Ac and eRF1 is described. The invention provides a method for identifying modulators of protein expression comprising screening for agents which affect the interaction between PP2A and eRF1, screening systems incorporating methods according to the invention and modulators of protein synthesis which target the eRF1-PP2A interaction.

Abstract: A rechargeable power pack comprises a housing, an energy storage device received in the housing, and a set of contacts extending from the housing and electrically coupled to the energy storage device to provide an electrical input current to the energy storage device at a first time and an electrical output current from the energy storage device at a second time. The electrical contacts are preferably formed as a set of prongs sized and dimensioned to be received in a standard electrical outlet. The rechargeable power pack may contain a charging circuit, a discharging circuit, and a switch to selectively couple the charging circuit and the discharging circuit between the contacts and the energy storage device. Additional circuitry may be provided for decoupling the charging circuit when either a voltage, temperature, or time has exceeded some predefined value.

Abstract: The invention concerns a method for screening a compound which is a candidate modulator of signal response comprising the steps of; (a) incubating the compound with the PH domain of a signaling molecule which is capable of fluorescing; (b) determining the phospholipid-induced modulation in florescence of the PH domain, an alteration of the florescence in the presence of the compound being indicative of a functional interaction between the compound and the PH domain.

Abstract: An improved spirometry assembly (20) is provided which includes a spirometer (22) and a sensor unit (24) coupled via handle assembly (26). The spirometer (22) has a reading slot (30) as well as an optical reader (36). The sensor unit (24) includes a tab (72) having at least one characterizing indicium (76) thereon which characterizes a response parameter of the sensor unit (24) upon flow of gas therethrough. In use, the reading slot (30) receives tab (72) and the reader (36) reads the indicium (76) and generates characterizing data representative thereof which is sent to a signal processor within the spirometer (22). The assembly (20) includes a measuring device such as a pressure transducer in operative communication with the interior ofthe sensor unit (24) for measuring a condition therein during patient-induced gas flow and generates pressure data.

Abstract: The current invention describes the identification of a novel widely-expressed human and D. melanogaster serine/threonine protein kinase (designated nuclear, Dbf2-related kinase, or Ndr; previously referred to as Ndr) and the use of this kinase for the identification of agonists and antagonists. The kinase is a nuclear protein and contains a short basic peptide, KRKAETWKRNRR, responsible for the nuclear accumulation.

Abstract: A rechargeable apparatus for mounting onto a battery-powered device and providing power. The apparatus includes a housing for slideably receiving the battery-powered device, a jack that is insertable into a power outlet on the battery-powered device, a rotatable AC plug mounted to the housing, and a night light coupled to the AC plug and positioned on the housing to supply illuminating light. Also, the apparatus includes at least one rechargeable battery and a charging circuit mounted inside the housing. The jack and night light may be mounted on a support arm that extends away from the housing.

Abstract: An improved spirometry assembly (20) is provided which includes a spirometer (22) and a sensor unit (24) coupled via handle assembly (26). The spirometer (22) has a reading slot (30) as well as an optical reader (36). The sensor unit (24) includes a tab (72) having at least one characterizing indicium (76) thereon which characterizes a response parameter of the sensor unit (24) upon flow of gas therethrough. In use, the reading slot (30) receives tab (72) and the reader (36) reads the indicium (76) and generates characterizing data representative thereof which is sent to a signal processor within the spirometer (22). The assembly (20) includes a measuring device such as a pressure transducer in operative communication with the interior of the sensor unit (24) for measuring a condition therein during patient-induced gas flow and generates pressure data.

Abstract: The current invention describes the identification of a novel widely-expressed human and D. melanogaster serine/threonine protein kinase (designated nuclear, Dbf2-related kinase, or Ndr; previously referred to as Ndr) and the use of this kinase for the identification of agonists and antagonists. The kinase is a nuclear protein and contains a short basic peptide, KRKAETWKRNRR, responsible for the nuclear accumulation.

Abstract: An improved spirometry assembly (20) is provided which includes a spirometer (22) and a sensor unit (24) coupled via handle assembly (26). The spirometer (22) has a reading slot (30) as well as an optical reader (36). The sensor unit (24) includes a tab (72) having at least one characterizing indicium (76) thereon which characterizes a response parameter of the sensor unit (24) upon flow of gas therethrough. In use, the reading slot (30) receives tab (72) and the reader (36) reads the indicium (76) and generates characterizing data representative thereof which is sent to a signal processor within the spirometer (22). The assembly (20) includes a measuring device such as a pressure transducer in operative communication with the interior of the sensor unit (24) for measuring a condition therein during patient-induced gas flow and generates pressure data.

Abstract: A dual chamber airbag and method for making a dual chamber side impact airbag with an integral vented panel. A partial vent panel is formed from a section in each airbag piece such that the to partial panels meet as the airbag pieces are assembled to make the airbag. The two panels are subsequently sewn together, thereby forming an integral vented panel separating an upper and lower chamber within the airbag.