Abstract: The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying modulators thereof. The invention relates to the fields of molecular biology, chemistry, pharmacology, and screening technology.

Abstract: A dispensing device (1) comprising a reservoir (3) for storing a fabric cleaning fluid (9) having a viscosity of over 10 Pa.s at rest or under an applied stress of up to 10 Pa, one or more dispensing orifices (13) in fluid communication with the reservoir (3), a movable platform movable (11) by means of a screw mechanism (19), whereby rotation of a screw (21) advances the movable platform (11) against the stored, fabric cleaning fluid (9) thereby dispensing a metered dose of the cleaning fluid (9) from the reservoir (3) to be dispensed via the dispensing orifices (13).

Abstract: Embodiments of the present invention introduce a novel recursive assembly process to automatically create a library of components. It starts with simple components used as building blocks and proceeds by repeatedly combining these randomly into more complex ones. The utility and quality of these random combinations of components are measured against a set of functional goals. Useful combinations then become new components in the library that can be used as building blocks for further random combination. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

Abstract: A razor which includes at least one razor blade, a container for a shaving composition and an electrically powered actuating mechanism, for causing shaving composition from the container to be discharged from the shaving head.

Abstract: An electrostimulation device (e.g., 100) consists of a single paddle (e.g., 102) and at least one lead (e.g., 110) for connecting the electrostimulation device to a pulse generator. The paddle has at least one electrode (e.g., 106) for providing electrical stimulation. The electrode(s) is provided in an area (A) of the paddle and a ratio of the width of the area to the length of the area is greater than 0.5. The present invention also relates to a paddle (e.g., 102) implantable in a vertebra.

Abstract: A gas mixing device feeds from two gas sources (1, 4), placing each gas into half of a chamber (17, 16) which is divided by a flexible physical barrier (12), such that pressure is equalised across the chambers (16, 17). Upon the release of each gas from each chamber at the same time into a mixing barrel (7), exit pressures and thus mixing characteristics are suitably controlled for a desired mix of gasses, due to the pressure balancing effect of the flexible barrier (12). The device might also be termed a divider or a dilutor. The device might be used in the mixing of low concentrations of carbon monoxide, such as 1 percent, in nitrogen with more nitrogen to dilute the concentration to 0.001 percent.

Abstract: The present invention relates to methods and products for improved production of the lantibiotic mersacidin. There is provided a method of producing a mersacidin variant which comprises introducing into a cell which is a ?MrsA host cell an expression vector encoding said variant, and recovering said variant from the cell culture. Preferred variants include the novel variants of Table 1, e.g. mersacidin F3W, said mersacidin F3W optionally having a further one or more variations, e.g. mersacidin F3W G8A. Also provided is a Bacillus cell which is a SigH deficient strain of Bacillus sp. HIL Y-85,54728 (NCIMB Accession Number NCIMB 41211); this cell may also be used in the production of mersacidin and its variants. Further aspects of the invention include a DNA cassette which comprises a nucleotide sequence encoding the mersacidin mrsA propeptide, and a method to transform a Bacillus HIL host cell with plasmid, which method includes the step of electroporation.

Abstract: A method of processing seismic data includes storing in a single file structure a first type of data representing an inline location, a second type of data representing a crossline location, and a third type of data representing at least one of a depth and time, said first, second and third type of data each being associated with a horizon of a poststack seismic trace at a location defined by said inline location and said crossline location; and storing in said single file structure at least a fourth type of data representing an attribute associated with said horizon of said poststack seismic trace at said location.

Abstract: The present invention relates generally to a heating system. More particularly, the invention encompasses an apparatus for a heating system and a method thereof. The invention also includes a heating system using microwave energy. The heating system is preferably provided for heating a heating media and heating domestic hot water. The heating system includes an enclosure and a heating tank which is located within the enclosure. A magnetron chamber is located in the enclosure above the tank. At least one heating rod with a hollow interior extends from the magnetron chamber into the lower compartment. The heating rod has an upper section that is located in the magnetron chamber and a lower section that is located in the tank. At least one heat absorbing mixture or media is located within each heating rod, and a microwave guide is located at the top or upper section of each heating rod. A magnetron is mounted on each microwave wave guide.

Abstract: A protective device for use in the protection of at least a portion of an elongated article which includes a main body, first and second parts which are connectible together such that, in an assembled position, the main body has a chamber therein. The first and second parts each have two longitudinal extending side portions, respective side edge portions of the first part being adapted to cooperate with the respective side edge portions of the second part to connect the two parts together in the assembled position.

Abstract: An electro-optic device is disclosed which has a plurality of independently-gatable portions. One example is an image intensifier having a number of segmented photocathode areas (GP). The corresponding portions of the intensifier can be energized independently via contact stripe (CS). Used in conjunction with an appropriate trigger signal generator, imaging device and beam splitter, the device may be used to capture a series of images at very high speed. An electrical device having a reflective tunnel for generating a plurality of input images is also disclosed.

Abstract: Embodiments of the present invention introduce a novel recursive assembly process to automatically create a library of components. It starts with simple components used as building blocks and proceeds by repeatedly combining these randomly into more complex ones. The utility and quality of these random combinations of components are measured against a set of functional goals. Useful combinations then become new components in the library that can be used as building blocks for further random combination. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

Abstract: An electro-optic device is disclosed which has a plurality of independently-gatable portions. One example is an image intensifier having a number of segmented photocathode areas (GP). The corresponding portions of the intensifier can be energized independently via contact strips (CS). Used in conjunction with an appropriate trigger signal generator, imaging device and beam splitter, the device may be used to capture a series of images at very high speed. An electrical device having a reflective tunnel for generating a plurality of input images is also disclosed.

Abstract: An apparatus for applying stretch film to goods on a pallet. It uses a basic core holder to hold a roll of stretch film which has an adjustable braking mechanism. In addition, the apparatus, which is portable, is ergonomically correct, easy to use, and has a pair of pre-stretch rollers which allow the stretch film to be pulled to increase its elasticity, thereby securing goods effectively on a pallet.

Abstract: Disclosed are crystallisable mutants of protein kinase B/Akt, crystals of these mutants, and X-ray coordinate data for the crystals. Methods of use of the coordinate data for identification of modulators of protein kinase activity and for structural analysis of other protein kinases are provided. Also provided are methods of activating protein kinases, in particular AGC kinases, using peptide or non-peptide mimetics of sequences from protein kinase B/Akt, or other AGC protein kinases such as PRK2.