Abstract: Systems and methods for administering trade orders are described. An embodiment comprises receiving, from a first server operated by a first trader, a communication including a first trade order and one or more selection criteria, the first trade order including at least one of a specified instrument, a specified quantity, and a specified price; determining that a database of trade orders does not contain a trade order matching the first trade order; identifying a plurality of traders satisfying the selection criteria; sending, to a plurality of second servers, a query including at least one of the specified instrument, the specified quantity, and the specified price; receiving, from a one of the plurality of second servers operated on behalf of a second trader, a positive response to the query; and facilitating execution of a trade between the first trader and the second trader for the specified instrument at the specified price.

Abstract: Systems and methods for distribution, storage, transport, administration and/or disposal of one or more therapeutic or diagnostic agents are disclosed. A storage device configured to connect to a delivery system for delivering the therapeutic or diagnostic agent has a housing with a chamber, a vessel having an access port positioned within the chamber. The door is movable relative to the housing between a closed position and an open position. In the closed position, the door covers an opening in the housing to enclose the chamber, and, in the open position, the door reveals the opening for accessing the access port of the vessel. The door is moveable between the closed position and the open position in response to actuation by an access mechanism of the delivery system.

Abstract: A method includes a data protection system determining, based on a first security threat detection process, that a storage system is possibly being targeted by a security threat; performing, based on the determining that the storage system is possibly being targeted by the security threat, a first remedial action with respect to the storage system, the first remedial action comprising generating a snapshot of data stored by the storage system; confirming, based on a second security threat detection process, whether the storage system is possibly being targeted by the security threat; and performing, based on the confirming whether the storage system is possibly being targeted by the security threat, a second remedial action with respect to the storage system, the second remedial action comprising specifying a retention duration with respect to the snapshot.

Abstract: An adaptive holder is used to provide those lacking fine hand motor control skills and limited arm and shoulder range of motion with the ability to conveniently extend and orient utensils such as forks and spoons. Used with a universal adapter cuff, the holder includes a slotted head which receives the utensil handle. A gripping portion, attached to the head, is received by the cuff. The utensil may be angularly oriented relative to the head and is secured thereto by a frictional interference fit.

Abstract: Techniques for building automated workflow sequences associated with a document review platform are provided. A method includes accessing trigger event data from a trigger event database and action data from an action database; presenting a user interface to create a workflow; adding a function block to the workflow by: detecting a selection of an add function block option; presenting a function block including at least one of (i) a user-selectable option to select a trigger event from a list of trigger events populated based on the trigger event data or (ii) a user-selectable option to select an action from a list of actions populated based on the action data; and presenting the function block including at least one of a selected trigger event or a selected action; detecting that the workflow is ready for deployment; translating the workflow into a logic-based representation of the workflow; and deploying the logic-based representation.

Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Abstract: An embodiment includes a method of vulnerability detection and mitigation in a managed network. The method includes receiving a defined state of a product on a managed endpoint of a managed network. The method includes detecting a trigger event in the managed network. The trigger event is indicative of a change to the managed device or to the product that is inconsistent with the defined state. Responsive to detection of the trigger event, the method includes automatically implementing a product modification process. The product modification process includes distribution of at least one product update to a product installed at the managed endpoint.

Abstract: Systems and methods for facilitating a response to an event notifying signal. The system includes a network monitoring module, an assessment module, and a resource response module. The network monitoring module is configured for monitoring signals received over a data network for a presence of one or more event notifying signals indicative of a relevant incident within a geographic area. The assessment module is configured for determine that the relevant incident could impact any persons or property of an enterprise or organization within the geographic area. The assessment module is also configured to identify a group of people of the enterprise or organization who could be impacted by the relevant incident. The resource response module is configured to send a response to a computing device associated with each person of the group of people. The response provides an indication of the relevant incident.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server. The approaches include intercepting requests to the SaaS server from a user group and monitoring a rate of API calls the API calls forwarded to the SaaS server, identifying one or more power users based on a notification threshold value for the user group, and managing the rate of the API calls for the requests submitted by the identified power users of the user group in accordance with an API call throttle limit, thus remediating triggering of the throughput penalty.

Abstract: A fuel cell system includes a dry end unit, a wet end unit comprising a terminal-compression plate, an insulator plate, and a base plate, and a plurality of fuel cells disposed between the dry end unit and the wet end unit. Each of the plurality of fuel cells includes a perimeter area that surrounds the plurality of fuel cells. The terminal-compression plate functions as a compression plate and a terminal plate, and where the base plate is used to uniformly compress the plurality of fuel cells through the insulator plate and the terminal-compression plate.

Abstract: Described herein are systems and methods for real-time fault detection in electrical circuits. Various embodiments provide a fault detection circuit that uses a resistor network that is controlled to detect an internal current leak in multiple directions, e.g., to ground or to a power supply. The magnitude of the leakage current may be estimated from voltage measurements at voltage pins. In addition, as part of circuit diagnostics, open and short circuit fault conditions may be identified by using current sources and measuring deflections at the voltage pins.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server. The approaches include intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, identifying one or more power users from the user group based on the rate of generated notifications, and throttling the rate of the API calls for the requests submitted by the identified power users of the user group to the SaaS server in accordance with an API call throttle limit, thus reducing triggering of the throughput penalty.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.