Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: A rental self-service (“RSS”) computer system, including a processor and a memory, is provided. The processor is programmed to: (i) verify that a policyholder is eligible to receive a replacement rental; (ii) transmit a customized link to the eligible policyholder; (iii) receive an access request for access of a rental self-service portal, (iv) retrieve policyholder data using information extracted from the customized link; (v) pre-populate a portion of a searchable interface of the rental self-service portal using the retrieved policyholder data; (vi) cause rental vehicle data to be displayed to enable the policyholder to view available rental options and select a vehicle class; (vii) calculate a policyholder cost for renting a selected vehicle class; and (viii) cause to be displayed on the user device (a) the calculated policyholder cost and (b) an option to confirm the rental reservation.

Abstract: An analog tamper-detection apparatus (ATAMP) for onboard analysis of a target device includes a plurality of antennas, each antenna of the plurality of antennas disposed within the target device and being electrically isolated from components of the target device. The ATAMP device further includes radio frequency (RF) front-end (RFFE) transmitter circuitry coupled to the plurality of antennas, the RFFE transmitter circuitry configured to illuminate the target device with a plurality of electromagnetic signals emitted via the plurality of antennas, to generate a plurality of mixed RF signals. The ATAMP device further includes RFFE receiver circuitry configured to receive emissions from the target device based on the mixed RF signals, and processing circuitry configured to perform subsequent analysis and evaluation of the target device based on the received emissions. The processing circuitry further generates a notification of the subsequent analysis and evaluation.

Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Abstract: An analog front-end circuit for self-calibrating a comparator, the circuit comprising a comparator in a comparator measurement path; a preamplifier coupled to the comparator by a set of switches; and an amplifier coupled to the preamplifier, the preamplifier receiving a reference signal as a first input and a user-definable reference as a second input, the user-definable reference generating a user-definable value chosen to create a known condition at an output of the preamplifier, the preamplifier determines a residual value that represents a measurement error in a signal path comprising the comparator and is used to adjust the user-definable reference value to calibrate the signal path such that threshold boundaries for the comparator can be adjusted to tighten a comparator specification.

Abstract: A rental self-service (“RSS”) computer system for enabling a policyholder of an automobile insurance policy to initiate an insurance replacement rental reservation after submission of an initial loss claim is provided. The RSS computer system includes a processor in communication with a memory. The processor is programmed to: (i) retrieve policyholder insurance data from an insurance provider database using a claim identifier associated with the initial loss claim submission, and a policyholder identifier associated with the policyholder; (ii) verify that the policyholder is eligible to receive an insurance replacement rental; (iii) cause to be displayed on a user device associated with the policyholder a searchable interface configured to enable the policyholder to search for at least one vendor location; (iv) receive a selected vehicle class inputted by the policyholder; (v) calculate a policyholder cost; (vi) display a cost summary; and (vii) receive confirmation of a rental reservation request.

Abstract: An RF clocked device can include a signal processor operable to receive an RF signal having an RF signal frequency and output a clock signal having a clock frequency based on the RF signal frequency. The RF clocked device can also include a clock operable to receive, and operate, using the clock signal. The clock can output at least one of a time and a date. In addition, a clock system can include an RF clocked device. The RF clocked device can include a signal processor operable to receive an RF signal having an RF signal frequency and output a clock signal having a clock frequency based on the RF signal frequency. The RF clocked device can also include a clock operable to receive, and operate, using the clock signal. The clock can output at least one of a time and a date. The clock system can also include a client device operable to receive timing information from the RF clocked device.

Abstract: Described herein are systems and methods that allow for automatic detection of the highest available cell voltage and/or location of the top voltage in a battery stack, in real-time, without having to use separate, dedicated PCBs for different battery stack configurations, and without having to manually configure PCBs based on the number of cells each battery stack has. In certain embodiments, automatic detection is accomplished by a software-configurable battery management circuit that supports any battery pack size without the need to perform hardware modifications or the added cost of customizing boards for battery stacks that have different numbers of cells. In addition, a novel diode-OR analog multiplexer circuit allows the chip to be powered prior to the selection of the top cell.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: An analog tamper-detection apparatus (ATAMP) for onboard analysis of a target device includes a plurality of antennas, each antenna of the plurality of antennas disposed within the target device and being electrically isolated from components of the target device. The ATAMP device further includes radio frequency (RF) front-end (RFFE) transmitter circuitry coupled to the plurality of antennas, the RFFE transmitter circuitry configured to illuminate the target device with a plurality of electromagnetic signals emitted via the plurality of antennas, to generate a plurality of mixed RF signals. The ATAMP device further includes RFFE receiver circuitry configured to receive emissions from the target device based on the mixed RF signals, and processing circuitry configured to perform subsequent analysis and evaluation of the target device based on the received emissions. The processing circuitry further generates a notification of the subsequent analysis and evaluation.

Abstract: A helicopter includes a gimbal assembly, a first rotor assembly, a second rotor assembly, a fuselage, and a controller. The first rotor assembly, the second rotor assembly, and the fuselage are mechanically coupled to the gimbal assembly. The first rotor assembly includes a first rotor and the second rotor assembly includes a second rotor, the first rotor including a plurality of first fixed-pitch blades and the second rotor including a plurality of second fixed-pitch blades. Each of the plurality of first and the second fixed-pitch blades are coupled to a hub of its respective rotor via a hinge mechanism that is configured to allow each of the fixed-pitch blades to pivot from a first position to a second position, the first position being substantially parallel to the fuselage and the second position being substantially perpendicular to the fuselage.

Abstract: Described herein are systems and methods that reduce settling time in amplifier circuits, such as voltage sense amplifiers (VSA) or current sense amplifiers (CSA) circuits, that comprise a feedback path. When the feedback path is interrupted via a switch, a CSA circuit switches to open loop. A sample-and-hold circuit holds the output voltage of the amplifier, such that when a load is connected to the CSA circuit, the open loop settling time, which is shorter than the closed loop settling time, is allowed to pass before the CSA output voltage is measured, thereby, advantageously preventing any potential disturbance present at the CSA output from being fed back to the CSA input.

Abstract: An information handling system performs a method for analyzing attacks against a networked system of information handling systems. The method includes detecting a threat indicator, representing the threat indicator in part by numerical parameters, normalizing the numerical parameters, calculating one or more measures of association between the threat indicator and other threat indicators, finding an association of the threat indicator with another threat indicator based upon the normalized numerical parameters, and assigning to the threat indicator a probability that a threat actor group caused the attack, wherein the threat actor group was assigned to the other threat indicator.

Abstract: An information handling system performs a method for analyzing attacks against a networked system of information handling systems. The method includes detecting a threat indicator, representing the threat indicator in part by numerical parameters, normalizing the numerical parameters, calculating one or more measures of association between the threat indicator and other threat indicators, finding an association of the threat indicator with another threat indicator based upon the normalized numerical parameters, and assigning to the threat indicator a probability that a threat actor group caused the attack, wherein the threat actor group was assigned to the other threat indicator. In some embodiments, the normalizing may include transforming a distribution of the numerical parameters to a distribution with a standard deviation of 1 and a mean of 0. In some embodiments, the normalizing may include applying an empirical cumulative distribution function.

Abstract: Described herein are systems and methods that allow for automatic detection of the highest available cell voltage and/or location of the top voltage in a battery stack, in real-time, without having to use separate, dedicated PCBs for different battery stack configurations, and without having to manually configure PCBs based on the number of cells each battery stack has. In certain embodiments, automatic detection is accomplished by a software-configurable battery management circuit that supports any battery pack size without the need to perform hardware modifications or the added cost of customizing boards for battery stacks that have different numbers of cells. In addition, a novel diode-OR analog multiplexer circuit allows the chip to be powered prior to the selection of the top cell.

Abstract: A system for adjusting the compliance of a wheel is provided. In one embodiment, wheel segments are adjusted, causing the stiffness of the wheel to change. Such adjustments can be made while the wheel is rotating, allowing the wheel compliance to be changed while a vehicle is in motion.

Abstract: An improved wearable locator has an ultra-low power RF transceiver, GPS receiver, cellular network RF transceiver, processor, programmable non-volatile memory, LCD display, accelerometer and rechargeable battery. To ensure that the locator is within a perimeter, it can cooperate with a subordinate unit that includes an ultra-low power RF transceiver, processor, power supply, DC charging output, rechargeable battery, visual, audible and tactile enunciators and pushbutton, and can be plugged into an outlet or be unplugged and be mobile. Other wireless units can be used to define a perimeter.

Abstract: Described herein are systems and methods for real-time fault detection in electrical circuits. Various embodiments provide a fault detection circuit that uses a resistor network that is controlled to detect an internal current leak in multiple directions, e.g., to ground or to a power supply. The magnitude of the leakage current may be estimated from voltage measurements at voltage pins. In addition, as part of circuit diagnostics, open and short circuit fault conditions may be identified by using current sources and measuring deflections at the voltage pins.

Abstract: Described herein are systems and methods that reduce settling time in amplifier circuits, such as voltage sense amplifiers (VSA) or current sense amplifiers (CSA) circuits, that comprise a feedback path. When the feedback path is interrupted via a switch, a CSA circuit switches to open loop. A sample-and-hold circuit holds the output voltage of the amplifier, such that when a load is connected to the CSA circuit, the open loop settling time, which is shorter than the closed loop settling time, is allowed to pass before the CSA output voltage is measured, thereby, advantageously preventing any potential disturbance present at the CSA output from being fed back to the CSA input.

Abstract: A method of automatically generating a calibration file for a card handling device comprises automatically generating a calibration file stored in memory of a main control system for a card handling device. Automatically generating the calibration file comprises identifying at least one parameter associated with a rank area around a rank of at least a portion of the card, identifying at least one parameter associated with a suit area around a suit of the at least a portion of the card, and storing the at least one parameter associated with the rank area and the at least one parameter associated with the suit area in the calibration file. Additionally, a method of automatically generating deck libraries for one or more decks of cards comprises automatically generating a plurality of master images for the cards of the first deck type using the parameters from the calibration file.