Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: Provided is a system for adsorbing a gaseous component comprising nitrogen from a pressurized flow of air containing the gaseous component. The system comprises a first adsorption bed, and a second adsorption bed. Each of the adsorption beds are suitable for selectively adsorbing the gaseous component from the flow of air to produce a product gas having a higher oxygen concentration than that of the air. The system includes an adjustable feed gas supply which alternately supplies the first adsorption bed and the second adsorption bed with the air. The first adsorption bed is supplied with air during a first half cycle of operation of the system, and the second adsorption bed is then supplied with air during a second half cycle of operation of the system. The feed gas supply enables adjustment of at least one parameter relating to the amount or respective amounts of air being supplied to the first adsorption bed in the first half cycle and/or to the second adsorption bed in the second half cycle.

Abstract: A storm water drain tank module for assembly into a storm tank for storage of storm water includes a top platen, a bottom platen and a support spacer. The top platen has an upper surface and a top platen peripheral edge. The bottom platen has a bottom surface and a bottom platen peripheral edge. The support spacer is attached to the top and bottom platens to space the top platen relative to the bottom platen. A plurality of tabs and a plurality of slots are defined proximate the top and bottom platen peripheral edges, respectively. Each of the plurality of tabs extends outwardly away from the top and bottom platen peripheral edges, respectively, and each of the plurality of slots extends into the top and bottom platen peripheral edge. The plurality of slots is open in a lateral direction.

Abstract: Methods, devices, and systems for processing information are disclosed. An example device may comprise a metastructure comprising a plurality of physical features configured to transform an analog signal according to a kernel of an integral equation. The device may comprise one or more waveguides coupled to the metastructure and configured to recursively supply a transformed analog output signal of the metastructure to an input of the metastructure to iteratively cause one or more transformed analog signals output from the metastructure to converge to an analog signal representing a solution to the integral equation.

Abstract: The present disclosure provides an ankle joint mechanism, including a shank member, a first connecting link, a foot member, a second connecting link, and a force providing element. The foot member is coupled to the shank member at a first pivot point and coupled to the first connecting link at a second pivot point. The second connecting link is coupled to the first connecting link at a third pivot point and coupled to the shank member at a fourth pivot point. The force providing element is coupled to the second connecting link at a first end and coupled to either the shank member or the foot member at a second end.

Abstract: A method for aligning displayed data in an augmented reality (AR) display includes determining a selected location context associated with a piece of equipment, determining a process element associated with the piece of equipment and according to a selected engineering process, determining, according to a digital representation of the equipment, a first location of the process element, receiving meta-sensor location data for one or more meta-sensors in the piece of equipment and indicating a second location for each of the meta-sensors with respect to the selected location context, determining a third location of the AR display with respect to the selected location context, determining overlay data for the process element, determining a display location according to the first location, the third location and the location data of each meta-sensor, and displaying the overlay data at the display location.

Abstract: Disclosed herein is a data storage device with storage medium that stores encrypted user content data. A cryptography engine uses a cryptographic key to decrypt the encrypted user content data. An access controller receives, from a user device, a request to register the user device and generates a challenge for a manager device. The manager device is located remotely from the data storage device. The controller sends, to the user device, the challenge for the manager device; receives, from the user device, a response calculated by the manager device to approve the request to register; calculates the cryptographic key based at least partly on the response calculated by the manager device; and creates and stores authorization data associated with the user device. The authorisation data indicates the cryptographic key, to register the user device with the data storage device.

Abstract: An in-line security device to transfer cryptographic key material, the device comprising: a first connector configured to connect, via wire, with a host device; a second connector configured to connect, via wire, with a data storage device; a pass-through circuit between the first connector and the second connector to facilitate data communication between the host device and the data storage device; and a communication interface to send cryptographic key material to the data storage device via the second connector.

Abstract: Building integrated photovoltaic (BIPV) systems provide for solar panel arrays with improved aesthetics and efficiency that can replace a conventional roof surface structure. These BIPV systems can utilize photovoltaic PV roof tiles defined as glass tiles having photovoltaic elements embedded or incorporated into the body of the roof tile. Such PV roof tiles can include one or more lapping features for interfacing with adjacent tiles and features for electrically connecting multiples tiles within a course to an external power optimizer. Such PV roof tiles can utilize stamped glass that is stamped to define these features within an integrated glass tile and can further include texture, striations on the glass tile and/or color matched back layers or various other components to obscure visibility of any embedded solar cells and provide a more pleasing appearance.

Abstract: Multispecific molecules that include i) a tumor-targeting moiety; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A collapsible flotation device is provided and includes an inflatable member forming a closed loop and defining at least in part a first opening within the closed loop. The inflatable member has a first portion positioned to be a back support and a second portion configured to be disposed beneath a leg of the user, a floor of the first opening being disposed between the first and second portions. The inflatable member defines a second opening providing access of a foot of the user to water. The second opening has a smaller axial length than the first opening such that a third, forwardmost portion of the closed loop is positioned to be a foot support member.

Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

Abstract: Various methods and systems are provided for displaying to an operator an attenuation map of a filter relative to a current location of an anatomical feature of a subject; and in response to the anatomical feature being within a region of the attenuation map, prompting an operator to reposition the subject. In this way, centering of the anatomical feature relative to an attenuation system may be facilitated for improved image quality.

Abstract: A fill sheet for cooling heat transfer fluid in a cooling tower includes an air intake end, an air outlet end, a top edge and a bottom edge. The air outlet end is positioned opposite the air intake end along a lateral axis. The top edge connects the air intake end and the air outlet end and the bottom edge also connects the air intake end and the air outlet end. The bottom edge is positioned opposite the top edge along a vertical axis. A plurality of flutes extends generally parallel to the lateral axis between the air intake end and the air outlet end. An offset extends generally parallel to the vertical axis. A first flute of the plurality of flutes transitions from a first peak at a first side of the offset to a first valley at a second side of the offset.

Abstract: Methods of treating genital psoriasis, genital pruritus and genital psoriasis sexual activity impairment with anti-IL17A antibodies, including dose regimens and pharmaceutical formulations of anti-IL17A antibodies for use in the treatment of genital psoriasis, genital pruritus and genital psoriasis sexual activity impairment.

Abstract: The present application describes a network interface device that acts as an interface between a network service provided by a network service provider and one or more network access devices associated with a particular location and/or entity.

Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

Abstract: Molecules, e.g., multispecific molecules, targeting CSF1R or CCR2 and methods of using the same, are disclosed.