Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: A gaming machine includes a video display mounting configuration, such as for mounting a secondary video display to a base cabinet having a first or primary video display. The mounting comprises connectors on a display frame which drop into mounts of a display support. The mounting may include a locking mechanism. An alignment configuration is also provided, such as for aligning different gaming machine components such as two video displays and/or light rings, trim or the like, relative to one another in three dimensions.

Abstract: A gaming machine is provided with easily installable and serviceable components. The gaming machine includes a gaming cabinet having an interior space which houses components of the gaming machine, such as a subwoofer of an audio system. The subwoofer is securely mounted to the cabinet via a simple sliding mount which is secured in place with a locking element via a single fastener.

Abstract: Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.

Abstract: A fuel composition for a spark-ignition internal combustion engine comprises naphtha in an amount of at least 5% by volume, and an octane-boosting additive having the formula: (I) The well-to-wheel greenhouse gas emissions associated with the fuel composition are significantly lower than those associated with a conventional gasoline fuel of comparable performance.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A system and method are described for depositing a material onto a receiving surface, where the material is formed by use of a plasma to modify a source material in-transit to the receiving surface. The system comprises a microwave generator electronics stage. The system further includes a microwave applicator stage including a cavity resonator structure. The cavity resonator structure includes an outer conductor, an inner conductor, and a resonator cavity interposed between the outer conductor and the inner conductor. The system also includes a multi-component flow assembly including a laminar flow nozzle providing a shield gas, a zonal flow nozzle providing a functional process gas, and a source material flow nozzle configured to deliver the source material. The source material flow nozzle and zonal flow nozzle facilitate a reaction between the source material and the functional process gas within a plasma region.

Abstract: A sensor for monitoring rotors includes a rotating shaft coupled to a set of rotor blades and a non-rotating tube at least partially disposed within the rotating shaft and coupled to the rotating shaft. The non-rotating tube includes a first end and a second end, a sensor mount disposed within the non-rotating tube proximate to the second end of the non-rotating tube. One or more sensors are attached to the sensor mount.

Abstract: A roof integrated photovoltaic system includes a starter bar having a foot base and configured to be installed to a roof deck, a plurality of water shedding layers, and a photovoltaic module. One of the plurality of water shedding layers is configured to be installed over the foot base of the starter bar, and one of another of which is configured to overlap and be installed over the one of the plurality of water shedding layers. The system further includes a foot module configured to be attached to an upper portion of the photovoltaic module. A lower portion of the photovoltaic module is configured to align with the foot base of the starter bar, and the foot module is configured to be affixed on a last overlapping layer of the plurality of water shedding layers to the roof deck.

Abstract: Disclosed herein is a data storage device comprising a data path and an access controller. The data path comprises a data port configured to transmit data between a host computer and the data storage device. The data storage device is configured to register with the host computer as a block data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine is connected between the data port and the storage medium and uses a cryptographic key to decrypt the encrypted user content data. The access controller generates a challenge for an authorized device; sends the challenge to the authorized device; receives a response to the challenge from the authorized device over the communication channel; calculates the cryptographic key based on the response; and provides the cryptographic key to the cryptography engine to decrypt the encrypted user content data stored on the storage medium.

Abstract: A data storage device comprising a data path and an access controller, wherein: the data path comprises: a data port configured to transmit data between a host computer system and the data storage device, wherein the data storage device is configured to register with the host computer system as a block data storage device; a non-volatile storage medium configured to store user content data; and the access controller is configured to: repeatedly and automatically generate a dynamically changing unlock passcode for unlocking the data storage device; receive a first passcode including, at least, an input passcode provided by a user device external to the data storage device, wherein the input passcode is generated externally to the data storage device and synchronously with the generation of the unlock passcode by the access controller; and provide access to the user content data via the data port in response to the first passcode matching with a second passcode generated by the access controller, wherein the se

Abstract: Devices for the separation of components within a fluid are disclosed herein. The device typically includes layers of spacers and separation surfaces. The separation panels have channels with functionalized surfaces to attract and retain components within the fluid. The separation panels include a border (housing) to constrain the fluid.

Abstract: A coupler can connect one or more instruments to a robotic surgical arm. The coupler can include a base and an actuator. The base can be securable to the robotic surgical arm. The actuator can be operable to release or secure the stem to the base and the robotic surgical arm.

Abstract: Monoethylene glycol (MEG) may be reclaimed by a process that includes contacting a MEG-water-salt stream with a heat transfer fluid and then flash separating the MEG and water in the flash separator vessel where the pressure is higher than 0.3 barA (0.03 MPa), the temperature is in the range of above 120° C. to about 250° C., and the residence time of the MEG and water ranges from about 1 second to about 10 minutes, and then removing the MEG and water in an overhead of the flash separator vessel and removing the salt from the flash separator vessel. In some embodiments it is expected that the temperature of the process may range from above 165° C. to about 250° C. and/or that the pressure may be atmospheric.

Abstract: A device for registering a bone for a robotic knee arthroplasty with a surgical robot can include a plate and a registration device. The plate can be engageable with the bone and can include a lateral portion, a medial portion, and a hinge. The registration device can be connected to the plate and can be configured to interface with the surgical robot for registration of the plate and the bone.

Abstract: The present invention provides gene editing systems comprising gene editing dimerization switches comprising a first and second gene editing switch domain that allow for the regulation of a gene editing function by the introduction, e.g., administration, of a gene editing dimerization molecule having the ability to bring together a first gene editing switch domain and a second gene editing switch domain. A regulated gene editing function provides, e.g., less off-target side effects, and increases the therapeutic window. The present invention also provides improved FKBP/FRB-based dimerization switches wherein the FRB switch domain or the FKBP switch domain, or both the FRB and FKBP switch domains, comprise one or more mutations that optimize performance, e.g., that alter, e.g., enhance the formation of a complex between the first switch domain, the second switch domain, and the dimerization molecule, rapamycin, or a rapalog, e.g., RAD001.

Abstract: A method and system for locating a reflector in a formation. The method may comprise broadcasting a sonic waveform as a shear formation body wave or a compressional formation body wave into the formation, recording a reflected wave from a reflector with the one or more receivers as dipole data by the dipole receiver and quadrupole data by the quadrupole receiver, and processing the dipole data and the quadrupole data with an information handling system to determine a location of the reflector from the borehole sonic logging tool. The system may comprise a borehole sonic logging tool and an information handling system. The borehole sonic logging tool may comprise one or more transmitters configured to transmit a sonic waveform into a formation and one or more receivers configured to record a reflected wave as a dipole receiver for dipole data and a quadrupole receiver for quadrupole data.

Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.