Patents by Inventor Brian Hargreaves

Brian Hargreaves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8706188
    Abstract: A method for musculoskeletal tissue segmentation used in magnetic resonance imaging (MRI) is provided. MRI image data is collected using at least two different contrast mechanisms. Voxel values from data from each contrast mechanism are used as elements of a feature vector. The feature vector is compared with classification boundaries to classify musculoskeletal tissue type of the voxel. The previous two steps are repeated for a plurality of voxels. An image is generated from the classified musculoskeletal tissue types for the plurality of voxels to provide a musculoskeletal segmentation image.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: April 22, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Seungbum Koo, Brian A. Hargreaves, Garry E. Gold
  • Patent number: 8587311
    Abstract: A system and method for breast imaging is disclosed. The system is constructed as a modular RF coil system for an MR imaging apparatus and includes a fitted coil former constructed to have a shape and size so as to substantially conform to a breast of a patient to be imaged and a receiver coil array positioned on the fitted coil former and having a plurality of receiver coils arranged to form a coil array. At least one of a size of each of the plurality of receiver coils and a number of the plurality of receiver coils is based on a size of the fitted coil former. Based on its coil arrangement and its proximity to the breasts of the patient to be imaged, the receiver coil array of the modular RF coil system is capable of receiving MR data for parallel imaging.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: November 19, 2013
    Assignees: General Electric Company, The Board of Trustees of the Leland Stanford, Jr. University
    Inventors: Anderson Nnewihe, Brian Hargreaves, Bruce L. Daniel, Thomas Grafendorfer, Paul David Calderon, Fraser John Laing Robb
  • Patent number: 8508225
    Abstract: A method of acquiring T2-weighted and diffusion-weighted images is provided. The method includes acquiring a first image and a second image in a single magnetic resonance imaging (MRI) scan, where the first image and the second image have different echo times (TE). The single MRI scan includes a series of repeated RF excitation pulses, where the echo signal for the first image and the echo signal for the second image are acquired between a pair of RF excitation pulses. A spoiler gradient is disposed to provide a first diffusion weighting to the first image and a second diffusion weighting to the second image, where the first image and the second image have different T2 weightings and different diffusion weightings.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: August 13, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kristin L Granlund, Ernesto Staroswiecki, Brian A. Hargreaves
  • Publication number: 20130200892
    Abstract: A method of ordering slices for interleaved MRI is provided that includes selecting a number of interleaved slice locations (NS) each having a plurality of excitations (NE,S), where S is the slice number between 1 and NS and NE,S may differ for different slice numbers, selecting an excitation duration (TS) of each the excitation in each the slice, selecting a repetition time (TR) between successive excitations of the same slice, TR has a duration of Ni×TS, Ni is the number of interleaved slices per TR period, and arranging the order for the slices such that the total scan time (T) is minimized such that TR is the product of Ni and Ts, where Ni can be arbitrarily chosen between 1 and NT/NE,max where NT is the total number of excitations for all the slices and where NE,max is the maximum number of the excitations for one slice.
    Type: Application
    Filed: February 3, 2012
    Publication date: August 8, 2013
    Inventor: Brian A. Hargreaves
  • Patent number: 8432166
    Abstract: A magnetic resonance imaging system or method is provided including a balanced steady-state free-precession transient imaging (transient bSSFP) device capable of increasing the overall signal during transient bSSFP acquisition by fully or better utilization of the magnetization through variable RF flip angles. The transient bSSFP device is capable of generating a series of echoes with a desired transverse magnetization profile MT. It is further capable of generating RF pulses each having a distinct RF flip angle for each of the echoes in the series of echoes. The transient bSSFP device is coupled to a computer capable of calculating the distinct RF flip angle for the nth echo in the series of echoes. The computer calculation utilizes a program encoding an analytical inversion of the Bloch equation. Once the RF flip angle is calculated, it is used by the transient bSSFP device in the generation of the nth echo.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: April 30, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Pauline W. Worters, Brian A. Hargreaves
  • Patent number: 8274286
    Abstract: A system and method for multi-spectral MR imaging near metal include a computer programmed to calculate an MR pulse sequence comprising a plurality of RF pulses configured to excite spins in an imaging object and comprising a plurality of volume selection gradients and determine a plurality of distinct offset frequency values. For each respective determined offset frequency value, the computer is programmed to execute the MR pulse sequence having a central transmit frequency and a central receive frequency of the MR pulse sequence set to the respective determined offset frequency value. The computer is also programmed to acquire a three-dimensional (3D) MR data set for each MR pulse sequence execution and generate a composite image based on data from each of the acquired 3D MR data sets.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: September 25, 2012
    Assignees: General Electric Company, The Board of Trustees of the Leland Standford, Jr. University
    Inventors: Kevin M. Koch, Kevin F. King, Graeme C. McKinnon, Brian Hargreaves
  • Publication number: 20120112743
    Abstract: A method of acquiring T2-weighted and diffusion-weighted images is provided. The method includes acquiring a first image and a second image in a single magnetic resonance imaging (MRI) scan, where the first image and the second image have different echo times (TE). The single MRI scan includes a series of repeated RF excitation pulses, where the echo signal for the first image and the echo signal for the second image are acquired between a pair of RF excitation pulses. A spoiler gradient is disposed to provide a first diffusion weighting to the first image and a second diffusion weighting to the second image, where the first image and the second image have different T2 weightings and different diffusion weightings.
    Type: Application
    Filed: November 10, 2010
    Publication date: May 10, 2012
    Inventors: Kristin L. Granlund, Ernesto Staroswiecki, Brian A. Hargreaves
  • Publication number: 20110241683
    Abstract: A system and method for breast imaging is disclosed. The system is constructed as a modular RF coil system for an MR imaging apparatus and includes a fitted coil former constructed to have a shape and size so as to substantially conform to a breast of a patient to be imaged and a receiver coil array positioned on the fitted coil former and having a plurality of receiver coils arranged to form a coil array. At least one of a size of each of the plurality of receiver coils and a number of the plurality of receiver coils is based on a size of the fitted coil former. Based on its coil arrangement and its proximity to the breasts of the patient to be imaged, the receiver coil array of the modular RF coil system is capable of receiving MR data for parallel imaging.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 6, 2011
    Inventors: Anderson Nnewihe, Brian Hargreaves, Bruce L. Daniel, Thomas Grafendorfer, Paul David Calderon, Fraser John Laing Robb
  • Publication number: 20110210732
    Abstract: A magnetic resonance imaging system or method is provided including a balanced steady-state free-precession transient imaging (transient bSSFP) device capable of increasing the overall signal during transient bSSFP acquisition by fully or better utilization of the magnetization through variable RF flip angles. The transient bSSFP device is capable of generating a series of echoes with a desired transverse magnetization profile MT. It is further capable of generating RF pulses each having a distinct RF flip angle for each of the echoes in the series of echoes. The transient bSSFP device is coupled to a computer capable of calculating the distinct RF flip angle for the nth echo in the series of echoes. The computer calculation utilizes a program encoding an analytical inversion of the Bloch equation. Once the RF flip angle is calculated, it is used by the transient bSSFP device in the generation of the nth echo.
    Type: Application
    Filed: March 1, 2010
    Publication date: September 1, 2011
    Inventors: Pauline W. Worters, Brian A. Hargreaves
  • Patent number: 7951830
    Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: May 31, 2011
    Assignee: AstraZeneca AB
    Inventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
  • Patent number: 7928729
    Abstract: A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: April 19, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Wenmiao Lu, John M. Pauly, Garry E. Gold, Kim B. Pauly
  • Publication number: 20100308827
    Abstract: A system and method for multi-spectral MR imaging near metal include a computer programmed to calculate an MR pulse sequence comprising a plurality of RF pulses configured to excite spins in an imaging object and comprising a plurality of volume selection gradients and determine a plurality of distinct offset frequency values. For each respective determined offset frequency value, the computer is programmed to execute the MR pulse sequence having a central transmit frequency and a central receive frequency of the MR pulse sequence set to the respective determined offset frequency value. The computer is also programmed to acquire a three-dimensional (3D) MR data set for each MR pulse sequence execution and generate a composite image based on data from each of the acquired 3D MR data sets.
    Type: Application
    Filed: August 20, 2010
    Publication date: December 9, 2010
    Inventors: Kevin M. Koch, Kevin F. King, Graeme C. McKinnon, Brian Hargreaves
  • Patent number: 7777486
    Abstract: A method for magnetic resonance imaging (MRI) is provided. A magnetic resonance excitation is provided. A plurality of k-space echoes is acquired bi-directionally wherein at least one echo is an even echo acquired in a first direction and at least one echo is an odd echo acquired in a second direction opposite from the first direction. K-space echo realignment is corrected between the even and odd echoes. Field inhomogeneity induced artifacts are corrected. Chemical shift induced artifacts between at least two species are corrected.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: August 17, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Hargreaves, Wenmiao Lu
  • Patent number: 7710115
    Abstract: A method for magnetic resonance imaging (MRI) a first volume and a second volume spaced apart from the first volume is provided. The first volume is excited with a first linearly varying phase with respect to k-space. The second volume is excited with a second linearly varying phase with respect to k-space, wherein the first linearly varying phase has a different slope than the second linearly varying phase. Data in k-space is acquired line by line. The acquired data in k-space is Fourier transformed to image space. An image is formed with a first volume image and a second volume image from the transformed data. Use of phase modulation allows imaging with a reduced field-of-view, which can result in faster scan times or improved performance of parallel imaging acquisition strategies.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: May 4, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Brian Hargreaves
  • Publication number: 20100033179
    Abstract: A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.
    Type: Application
    Filed: August 7, 2008
    Publication date: February 11, 2010
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Wenmiao Lu, John M. Pauly, Garry E. Gold, Kim B. Pauly
  • Publication number: 20090306496
    Abstract: A method for musculoskeletal tissue segmentation used in magnetic resonance imaging (MRI) is provided. MRI image data is collected using at least two different contrast mechanisms. Voxel values from data from each contrast mechanism are used as elements of a feature vector. The feature vector is compared with classification boundaries to classify musculoskeletal tissue type of the voxel. The previous two steps are repeated for a plurality of voxels. An image is generated from the classified musculoskeletal tissue types for the plurality of voxels to provide a musculoskeletal segmentation image.
    Type: Application
    Filed: June 4, 2008
    Publication date: December 10, 2009
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Seungbum Koo, Brian A. Hargreaves, Garry E. Gold
  • Publication number: 20090227592
    Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
    Type: Application
    Filed: February 2, 2009
    Publication date: September 10, 2009
    Applicant: AstraZeneca AB
    Inventors: Scott BOYD, Peter William Rodney CAULKETT, Rodney Brian HARGREAVES, Suzanne Saxon BOWKER, Roger JAMES, Clifford David JONES, Darren McKERRECHER, Michael Howard BLOCK, Craig JOHNSTONE
  • Patent number: 7576535
    Abstract: Disclosed is a method of quantitatively separating tissue signals based on relaxation time differences. The method uses the transient signal decay in steady-state free precession (balanced SSFP) imaging to provide an alternative to standard CPMG methods of T2-relaxometry. The balanced SSFP technique allows 3-4 times the temporal resolution of CPMG, and also slows the short T2 decay so that it can be more accurately measured.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: August 18, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Brian A. Hargreaves
  • Patent number: 7524957
    Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: April 28, 2009
    Assignee: AstraZeneca AB
    Inventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
  • Publication number: 20090072826
    Abstract: A method for magnetic resonance imaging (MRI) is provided. A magnetic resonance excitation is provided. A plurality of k-space echoes is acquired bi-directionally wherein at least one echo is an even echo acquired in a first direction and at least one echo is an odd echo acquired in a second direction opposite from the first direction. K-space echo realignment is corrected between the even and odd echoes. Field inhomogeneity induced artifacts are corrected. Chemical shift induced artifacts between at least two species are corrected.
    Type: Application
    Filed: September 13, 2007
    Publication date: March 19, 2009
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Hargreaves, Wenmiao Lu