Patents by Inventor Brian Hargreaves

Brian Hargreaves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090072827
    Abstract: A method for magnetic resonance imaging (MRI) a first volume and a second volume spaced apart from the first volume is provided. The first volume is excited with a first linearly varying phase with respect to k-space. The second volume is excited with a second linearly varying phase with respect to k-space, wherein the first linearly varying phase has a different slope than the second linearly varying phase. Data in k-space is acquired line by line. The acquired data in k-space is Fourier transformed to image space. An image is formed with a first volume image and a second volume image from the transformed data. Use of phase modulation allows imaging with a reduced field-of-view, which can result in faster scan times or improved performance of parallel imaging acquisition strategies.
    Type: Application
    Filed: September 14, 2007
    Publication date: March 19, 2009
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Brian Hargreaves
  • Publication number: 20080207636
    Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
    Type: Application
    Filed: February 1, 2008
    Publication date: August 28, 2008
    Applicant: AstraZeneca AB
    Inventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
  • Patent number: 7390908
    Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: June 24, 2008
    Assignee: AstraZeneca AB
    Inventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Craig Johnstone, Clifford David Jones, Darren McKerrecher, Michael Howard Block
  • Patent number: 7332908
    Abstract: Disclosed is a wideband SSFP, wherein a standard balanced SSFP MRI sequence is played with repetition times of alternating lengths, TR and TRs, where TRs<TR. The result is significantly improved tradeoff between signal bandwidth and available acquisition interval lengths. This is particularly important as it enables the combination of balanced SSFP with high field imaging for many applications such as cardiac, musculoskeletal and abdominal imaging.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: February 19, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Krishna S. Nayak, Brian A. Hargreaves
  • Patent number: 7301341
    Abstract: A time-optimal MRI gradient design method utilizes constrained optimization to design minimum-time gradient waveforms that satisfy gradient amplitude and slew-rate limitations. Constraints are expressed as linear equations which are solved using linear programming, L1-norm formulation, or second-order cone programming (SOCP).
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: November 27, 2007
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Steven M. Conolly
  • Patent number: 7298144
    Abstract: Homodyne image reconstruction is combined with an iterative decomposition of water and fat from MR signals obtained from a partial k-space signal acquisition in order to maximize the resolution of calculated water and fat images. The method includes asymmetrical acquisition of under-sampled MRI data, obtaining low resolution images, and then estimating a magnetic field map and phase maps of water and fat image signals from the low resolution images. The acquired data is again filtered and Fourier transformed to obtain an estimate of combined fat and water signals using the estimated magnetic field map and phase maps. Water and fat images are then estimated from which phases of the water and fat images are determined. The real parts of the water and fat images are then used in calculating water and fat images using a homodyne process.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: November 20, 2007
    Assignees: The Board of Trustee of the Leland Stanford Junior University, General Electric Company
    Inventors: Scott B. Reeder, Brian A. Hargreaves, Jean H. Brittain
  • Publication number: 20070257671
    Abstract: Disclosed is a wideband SSFP, wherein a standard balanced SSFP MRI sequence is played with repetition times of alternating lengths, TR and TRS, where TRS<TR. The result is significantly improved tradeoff between signal bandwidth and available acquisition interval lengths. This is particularly important as it enables the combination of balanced SSFP with high field imaging for many applications such as cardiac, musculoskeletal and abdominal imaging.
    Type: Application
    Filed: May 4, 2006
    Publication date: November 8, 2007
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Krishna Nayak, Brian Hargreaves
  • Patent number: 7230108
    Abstract: Compounds of formula (I), wherein one of R1 and R2 is selected from a group (IA), ring A is substituted pyridin-z-yl of thiazol-z-yl, the other substituents are as described in the description and their use in the treatment or prevention of a disease or medical conditions mediated through glucokinase
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 12, 2007
    Assignee: AstraZeneca AB
    Inventors: Rodney Brian Hargreaves, Christopher Daniel Davies
  • Patent number: 7199140
    Abstract: The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: April 3, 2007
    Assignee: AstraZeneca AB
    Inventors: Barry Raymond Hayter, Gordon Stuart Currie, Rodney Brian Hargreaves, Peter William Rodney Caulkett, Roger James
  • Publication number: 20070057672
    Abstract: MRI signals from two species such as fat and water are separated by repeatedly applying a steady state free precession (SSFP) sequence to an object with the phase of each RF excitation pulse in a sequence being increased by 2?n/N radians on each repetition, where acquisition number n ranges from 1 to N. Alternatively, center frequency for each scan is incremented compared with the first scan center frequency. Images are reconstructed from the acquired signals and summed. Slowing varying phase due to sources other than chemical shift can be removed. Species signals are separated based on phase (sign) of the summed image signals.
    Type: Application
    Filed: September 13, 2005
    Publication date: March 15, 2007
    Inventors: Brian Hargreaves, Neal Bangerter
  • Patent number: 7187170
    Abstract: MRI signals from two species such as fat and water are separated by repeatedly applying a steady state free precession (SSFP) sequence to an object with the phase of each RF excitation pulse in a sequence being increased by 2?n/N radians on each repetition, where acquisition number n ranges from 1 to N. Alternatively, center frequency for each scan is incremented compared with the first scan center frequency. Images are reconstructed from the acquired signals and summed. Slowing varying phase due to sources other than chemical shift can be removed. Species signals are separated based on phase (sign) of the summed image signals.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: March 6, 2007
    Assignee: The Board of Trustees of the Leland Stanford Junior Univeristy
    Inventors: Brian A. Hargreaves, Neal K. Bangerter
  • Patent number: 7160906
    Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: January 9, 2007
    Assignee: AstraZeneca AB
    Inventors: Barry Raymond Hayter, Gordon Stuart Currie, Rodney Brian Hargreaves, Roger James, Clifford David Jones, Darren McKerrecher, Joanne Victoria Allen, Peter William Rodney Caulkett, Craig Johnstone, Harold Gaskin
  • Patent number: 7151370
    Abstract: MRI signals from two species such as water and fat are separated by using two SSFP acquisitions (S1, S2) with the two species signals having two different phase differences (e.g., 180°, 90°) and binomial quadratic expansion in which the species are determined based on magnitude and sign of S1 and the magnitude of S2.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: December 19, 2006
    Assignee: The Trustees of the Leland Stanford Junior University
    Inventor: Brian A. Hargreaves
  • Publication number: 20060250132
    Abstract: Homodyne image reconstruction is combined with an iterative decomposition of water and fat from MR signals obtained from a partial k-space signal acquisition in order to maximize the resolution of calculated water and fat images. The method includes asymmetrical acquisition of under-sampled MRI data, obtaining low resolution images, and then estimating a magnetic field map and phase maps of water and fat image signals from the low resolution images. The acquired data is again filtered and Fourier transformed to obtain an estimate of combined fat and water signals using the estimated magnetic field map and phase maps. Water and fat images are then estimated from which phases of the water and fat images are determined. The real parts of the water and fat images are then used in calculating water and fat images using a homodyne process.
    Type: Application
    Filed: October 18, 2005
    Publication date: November 9, 2006
    Inventors: Scott Reeder, Brian Hargreaves, Jean Brittain
  • Patent number: 7046003
    Abstract: A pulse sequence for use in steady state free precession (SSFP) imaging sequences includes a RF pulse and a time-varying gradient pulse based on a conventional design algorithm such as the Shinnar-LeRoux (SLR) pulse design algorithm and in which amplitude of the RF pulse and gradient pulse are increased while pulse time is decreased thereby reducing imaging time and improving slab profiles.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: May 16, 2006
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Charles H. Cunningham, Steven M. Conolly
  • Publication number: 20060061358
    Abstract: A pulse sequence for use in steady state free precession (SSFP) imaging sequences includes a RF pulse and a time-varying gradient pulse based on a conventional design algorithm such as the Shinnar-LeRoux (SLR) pulse design algorithm and in which amplitude of the RF pulse and gradient pulse are increased while pulse time is decreased thereby reducing imaging time and improving slab profiles.
    Type: Application
    Filed: September 20, 2004
    Publication date: March 23, 2006
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Brian Hargreaves, Charles Cunningham, Steven Conolly
  • Patent number: 6922054
    Abstract: Magnetic resonance imaging of a body uses steady state free precession with material separation for the selective imaging of two species, such as blood or fat. The refocusing property of SSFP is used with signal phase detection to suppress either water or lipid. Phase and/or frequency of the RF excitation pulse and repetition time are selected so that resonant frequencies of water, fw, and lipid, fl, are on opposite sides of the signal null frequency.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: July 26, 2005
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Shreyas Vasanawala
  • Publication number: 20050148858
    Abstract: Disclosed is a method of quantitatively separating tissue signals based on relaxation time differences. The method uses the transient signal decay in steady-state free precession (balanced SSFP) imaging to provide an alternative to standard CPMG methods of T2-relaxometry. The balanced SSFP technique allows 3-4 times the temporal resolution of CPMG, and also slows the short T2 decay so that it can be more accurately measured.
    Type: Application
    Filed: December 8, 2003
    Publication date: July 7, 2005
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Brian Hargreaves
  • Publication number: 20050077895
    Abstract: A time-optimal MRI gradient design method utilizes constrained optimization to design minimum-time gradient waveforms that satisfy gradient amplitude and slew-rate limitations. Constraints are expressed as linear equations which are solved using linear programming, L1-norm formulation, or second-order cone programming (SOCP).
    Type: Application
    Filed: October 8, 2003
    Publication date: April 14, 2005
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY
    Inventors: Brian Hargreaves, Steven Conolly
  • Publication number: 20050040821
    Abstract: Magnetic resonance imaging of a body uses steady state free precession with material separation for the selective imaging of two species, such as blood or fat. The refocusing property of SSFP is used with signal phase detection to suppress either water or lipid. Phase and/or frequency of the RF excitation pulse and repetition time are selected so that resonant frequencies of water, fw, and lipid, fl, are on opposite sides of the signal null frequency.
    Type: Application
    Filed: August 18, 2003
    Publication date: February 24, 2005
    Inventors: Brian Hargreaves, Shreyas Vasanawala