Patents by Inventor Brian Hargreaves
Brian Hargreaves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7951830Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).Type: GrantFiled: February 2, 2009Date of Patent: May 31, 2011Assignee: AstraZeneca ABInventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
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Patent number: 7928729Abstract: A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.Type: GrantFiled: August 7, 2008Date of Patent: April 19, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Brian A. Hargreaves, Wenmiao Lu, John M. Pauly, Garry E. Gold, Kim B. Pauly
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Publication number: 20100308827Abstract: A system and method for multi-spectral MR imaging near metal include a computer programmed to calculate an MR pulse sequence comprising a plurality of RF pulses configured to excite spins in an imaging object and comprising a plurality of volume selection gradients and determine a plurality of distinct offset frequency values. For each respective determined offset frequency value, the computer is programmed to execute the MR pulse sequence having a central transmit frequency and a central receive frequency of the MR pulse sequence set to the respective determined offset frequency value. The computer is also programmed to acquire a three-dimensional (3D) MR data set for each MR pulse sequence execution and generate a composite image based on data from each of the acquired 3D MR data sets.Type: ApplicationFiled: August 20, 2010Publication date: December 9, 2010Inventors: Kevin M. Koch, Kevin F. King, Graeme C. McKinnon, Brian Hargreaves
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Patent number: 7777486Abstract: A method for magnetic resonance imaging (MRI) is provided. A magnetic resonance excitation is provided. A plurality of k-space echoes is acquired bi-directionally wherein at least one echo is an even echo acquired in a first direction and at least one echo is an odd echo acquired in a second direction opposite from the first direction. K-space echo realignment is corrected between the even and odd echoes. Field inhomogeneity induced artifacts are corrected. Chemical shift induced artifacts between at least two species are corrected.Type: GrantFiled: September 13, 2007Date of Patent: August 17, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Brian Hargreaves, Wenmiao Lu
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Patent number: 7710115Abstract: A method for magnetic resonance imaging (MRI) a first volume and a second volume spaced apart from the first volume is provided. The first volume is excited with a first linearly varying phase with respect to k-space. The second volume is excited with a second linearly varying phase with respect to k-space, wherein the first linearly varying phase has a different slope than the second linearly varying phase. Data in k-space is acquired line by line. The acquired data in k-space is Fourier transformed to image space. An image is formed with a first volume image and a second volume image from the transformed data. Use of phase modulation allows imaging with a reduced field-of-view, which can result in faster scan times or improved performance of parallel imaging acquisition strategies.Type: GrantFiled: September 14, 2007Date of Patent: May 4, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Brian Hargreaves
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Publication number: 20100033179Abstract: A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.Type: ApplicationFiled: August 7, 2008Publication date: February 11, 2010Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Brian A. Hargreaves, Wenmiao Lu, John M. Pauly, Garry E. Gold, Kim B. Pauly
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Publication number: 20090306496Abstract: A method for musculoskeletal tissue segmentation used in magnetic resonance imaging (MRI) is provided. MRI image data is collected using at least two different contrast mechanisms. Voxel values from data from each contrast mechanism are used as elements of a feature vector. The feature vector is compared with classification boundaries to classify musculoskeletal tissue type of the voxel. The previous two steps are repeated for a plurality of voxels. An image is generated from the classified musculoskeletal tissue types for the plurality of voxels to provide a musculoskeletal segmentation image.Type: ApplicationFiled: June 4, 2008Publication date: December 10, 2009Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Seungbum Koo, Brian A. Hargreaves, Garry E. Gold
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Publication number: 20090227592Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).Type: ApplicationFiled: February 2, 2009Publication date: September 10, 2009Applicant: AstraZeneca ABInventors: Scott BOYD, Peter William Rodney CAULKETT, Rodney Brian HARGREAVES, Suzanne Saxon BOWKER, Roger JAMES, Clifford David JONES, Darren McKERRECHER, Michael Howard BLOCK, Craig JOHNSTONE
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Patent number: 7576535Abstract: Disclosed is a method of quantitatively separating tissue signals based on relaxation time differences. The method uses the transient signal decay in steady-state free precession (balanced SSFP) imaging to provide an alternative to standard CPMG methods of T2-relaxometry. The balanced SSFP technique allows 3-4 times the temporal resolution of CPMG, and also slows the short T2 decay so that it can be more accurately measured.Type: GrantFiled: December 8, 2003Date of Patent: August 18, 2009Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Brian A. Hargreaves
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Patent number: 7524957Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).Type: GrantFiled: February 1, 2008Date of Patent: April 28, 2009Assignee: AstraZeneca ABInventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
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Publication number: 20090072827Abstract: A method for magnetic resonance imaging (MRI) a first volume and a second volume spaced apart from the first volume is provided. The first volume is excited with a first linearly varying phase with respect to k-space. The second volume is excited with a second linearly varying phase with respect to k-space, wherein the first linearly varying phase has a different slope than the second linearly varying phase. Data in k-space is acquired line by line. The acquired data in k-space is Fourier transformed to image space. An image is formed with a first volume image and a second volume image from the transformed data. Use of phase modulation allows imaging with a reduced field-of-view, which can result in faster scan times or improved performance of parallel imaging acquisition strategies.Type: ApplicationFiled: September 14, 2007Publication date: March 19, 2009Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Brian Hargreaves
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Publication number: 20090072826Abstract: A method for magnetic resonance imaging (MRI) is provided. A magnetic resonance excitation is provided. A plurality of k-space echoes is acquired bi-directionally wherein at least one echo is an even echo acquired in a first direction and at least one echo is an odd echo acquired in a second direction opposite from the first direction. K-space echo realignment is corrected between the even and odd echoes. Field inhomogeneity induced artifacts are corrected. Chemical shift induced artifacts between at least two species are corrected.Type: ApplicationFiled: September 13, 2007Publication date: March 19, 2009Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Brian Hargreaves, Wenmiao Lu
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Publication number: 20080207636Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).Type: ApplicationFiled: February 1, 2008Publication date: August 28, 2008Applicant: AstraZeneca ABInventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
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Patent number: 7390908Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).Type: GrantFiled: August 15, 2002Date of Patent: June 24, 2008Assignee: AstraZeneca ABInventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Craig Johnstone, Clifford David Jones, Darren McKerrecher, Michael Howard Block
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Patent number: 7332908Abstract: Disclosed is a wideband SSFP, wherein a standard balanced SSFP MRI sequence is played with repetition times of alternating lengths, TR and TRs, where TRs<TR. The result is significantly improved tradeoff between signal bandwidth and available acquisition interval lengths. This is particularly important as it enables the combination of balanced SSFP with high field imaging for many applications such as cardiac, musculoskeletal and abdominal imaging.Type: GrantFiled: May 4, 2006Date of Patent: February 19, 2008Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Krishna S. Nayak, Brian A. Hargreaves
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Patent number: 7301341Abstract: A time-optimal MRI gradient design method utilizes constrained optimization to design minimum-time gradient waveforms that satisfy gradient amplitude and slew-rate limitations. Constraints are expressed as linear equations which are solved using linear programming, L1-norm formulation, or second-order cone programming (SOCP).Type: GrantFiled: October 8, 2003Date of Patent: November 27, 2007Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Brian A. Hargreaves, Steven M. Conolly
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Patent number: 7298144Abstract: Homodyne image reconstruction is combined with an iterative decomposition of water and fat from MR signals obtained from a partial k-space signal acquisition in order to maximize the resolution of calculated water and fat images. The method includes asymmetrical acquisition of under-sampled MRI data, obtaining low resolution images, and then estimating a magnetic field map and phase maps of water and fat image signals from the low resolution images. The acquired data is again filtered and Fourier transformed to obtain an estimate of combined fat and water signals using the estimated magnetic field map and phase maps. Water and fat images are then estimated from which phases of the water and fat images are determined. The real parts of the water and fat images are then used in calculating water and fat images using a homodyne process.Type: GrantFiled: October 18, 2005Date of Patent: November 20, 2007Assignees: The Board of Trustee of the Leland Stanford Junior University, General Electric CompanyInventors: Scott B. Reeder, Brian A. Hargreaves, Jean H. Brittain
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Publication number: 20070257671Abstract: Disclosed is a wideband SSFP, wherein a standard balanced SSFP MRI sequence is played with repetition times of alternating lengths, TR and TRS, where TRS<TR. The result is significantly improved tradeoff between signal bandwidth and available acquisition interval lengths. This is particularly important as it enables the combination of balanced SSFP with high field imaging for many applications such as cardiac, musculoskeletal and abdominal imaging.Type: ApplicationFiled: May 4, 2006Publication date: November 8, 2007Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Krishna Nayak, Brian Hargreaves
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Patent number: 7230108Abstract: Compounds of formula (I), wherein one of R1 and R2 is selected from a group (IA), ring A is substituted pyridin-z-yl of thiazol-z-yl, the other substituents are as described in the description and their use in the treatment or prevention of a disease or medical conditions mediated through glucokinaseType: GrantFiled: November 13, 2003Date of Patent: June 12, 2007Assignee: AstraZeneca ABInventors: Rodney Brian Hargreaves, Christopher Daniel Davies
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Patent number: 7199140Abstract: The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.Type: GrantFiled: June 24, 2002Date of Patent: April 3, 2007Assignee: AstraZeneca ABInventors: Barry Raymond Hayter, Gordon Stuart Currie, Rodney Brian Hargreaves, Peter William Rodney Caulkett, Roger James