Abstract: The invention discloses approaches to reduce expression of a gene in a cell.

Abstract: An agricultural machine having: a header frame; a crop cutter mounted to the frame; a first transmission operatively connected to the crop cutter and defining a first power flow path to drive the crop cutter by operative motion of a first transmission input; an auger rotatably mounted to the frame to rotate relative to the frame about a rotation axis; and a second transmission operatively connected between the crop cutter and the auger and defining a second power flow path to drive the auger by operative motion of the crop cutter.

Abstract: A directional headlamp assembly for independently directing light from a pair of headlamps includes a pair of headlamp modules and a controller. Each headlamp module replaces a respective headlamp of a pair of existing headlamps of a vehicle. The headlamp module comprises a first housing, which insertable of into an opening created upon removal of the respective headlamp, so that the first housing is engaged to the vehicle. A bulb is pivotally engaged to a front of the first housing. An actuator is engaged to and positioned in the first housing. The actuator is operationally engaged to the bulb. The controller is mountable within a passenger compartment of the vehicle so that it is accessible to a driver of the vehicle. The controller is independently and operationally engaged to each of the actuators and thus is positioned to selectively actuate each actuator to direct light emitted by an associated bulb.

Abstract: In alternative embodiments, provided are compositions such as antibodies, e.g., single chain antibodies, that target 3-repeat (3R) Tau for the treatment of neurodegenerative disorders and taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation, and methods for making and using them. In alternative embodiments, provided are brain-penetrating antibodies that specifically recognize 3R Tau, and methods of using them to treat, ameliorate, prevent or decrease the symptoms of neurodegenerative disorders including taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation.

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for transporting nucleic acids such as oligonucleotides to and across the blood brain barrier (BBB) and into the central nervous system (CNS). In alternative embodiments, provided herein are ApoB11-comprising chimeric or synthetic peptides useful for the delivery of nucleic acids such as oligonucleotides to the CNS for the treatment, prevention or amelioration of a CNS disease, infection or condition, or for diagnostic purposes.

Abstract: In alternative embodiments, provided are compositions such as antibodies, e.g., single chain antibodies, that target 3-repeat (3R) Tau for the treatment of neurodegenerative disorders and taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation, and methods for making and using them. In alternative embodiments, provided are brain-penetrating antibodies that specifically recognize 3R Tau, and methods of using them to treat, ameliorate, prevent or decrease the symptoms of neurodegenerative disorders including taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation.

Abstract: The disclosure is related to searching for a second device to provide a service that a first device is attempting to establish. The first device sends a search profile and a capabilities profile to the second device using near field communication (NFC), the search profile including criteria describing the service the first device is attempting to establish, the capabilities profile including connection capabilities of the first device, receives a score from the second device, the score indicating a closeness of a match between the search profile and the capabilities profile and one or more services and capabilities of the second device, and determines whether to connect with the second device to establish the service based on the received score.

Abstract: A pressure vessel comprising a pipe closed at each end with a novel plug/compression cap, the plug at one end of the pipe having a port for connection to a pressure regulating device.

Abstract: This invention relates to methods of fabricating components of a pressure vessel using a dicyclopentadiene prepolymer formulation in which the purity of the dicyclopentadiene is at least 92% wherein the formulation further comprises a reactive ethylene monomer that renders the prepolymer formulation flowable at ambient temperatures and to pressure vessels that are fabricated by said methods.

Abstract: A pressure vessel comprising a pipe closed at each end with a novel plug/compression cap, the plug at one end of the pipe having a port for connection to a pressure regulating device.

Abstract: A pressure vessel comprising a pipe closed at each end with a novel plug/compression cap, the plug at one end of the pipe having a port for connection to a pressure regulating device.