Abstract: Thin-film solid state batteries architectures and methods of manufacture are provided. Architectures include solid-state batteries with one or more cathodes, electrolytes, anodes deposited onto a substrate. Architectures may be used for solid state lithium batteries. The various fabrication techniques may be used to create a solid state battery is millimeters thick or smaller. These thin-film batteries may be small, light, and have a high energy density.

Abstract: The present disclosure describes methods of inserting lithium into an electrochromic device after completion. In the disclosed methods, an ideal amount of lithium can be added post-fabrication to maximize or tailor the free lithium ion density of a layer or the coloration range of a device. Embodiments are directed towards a method to insert lithium into the main device layers of an electrochromic device as a post-processing step after the device has been manufactured. In an embodiment, the methods described are designed to maximize the coloration range while compensating for blind charge loss.

Abstract: A blood pressure device including a compressible material can be placed around a limb of a patient (e.g. a band or cuff). Further, the blood pressure device can include a sleeve that, at least partially, covers the compressible material and is capable of compressing the compressible material to occlude a patient's blood vessel without inflating the sleeve. In some embodiments, the sleeve can compress the compressible material using a motor assembly. This motor assembly can include a motor and any additional mechanical devices that can be used to facilitate compressing the compressible material. For example, the motor assembly may include one or more of the following: a cable, a pulley, and a gear assembly, such as a worm drive or any other gear assembly that can facilitate compressing the compressible material.

Abstract: An alarm system can include one or more processors. Such processors can receive physiological parameter data associated with a patient. The one or more processors can also select an alarm pattern based at least in part on an indicator of an attribute of the patient. The alarm pattern can include a plurality of different thresholds and corresponding periods of time. Further, the one or more processors can generate an alarm when a value associated with the physiological parameter data satisfies at least one threshold of the plurality of thresholds for the period of time corresponding to the at least one threshold.

Abstract: The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation—including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation.

Abstract: A fishing device for indicating a lure strike from fishes is disclosed. The device may be a strike indicator that may include a hollow body filled with trapped air, where the strike indicator includes a tab having an opening formed therein and a grommet made from a hard, durable material seated in the opening. Alternatively, the device may be a fishing lure that may be attachable to a fishing hook and having a hollow body filled with trapped air and an attachment mechanism for attaching the lure to the fishing leader and/or fishing line. For example, the fishing lure may be a fishing fly having a hollow body filled with trapped air. In either embodiment, the device may be made from a lightweight, resilient material, for example ethylene vinyl acetate or other similar thermoplastic material.

Abstract: Provided are methods for reducing food consumption, and methods for altering behavioral, neurological, psychological, or physiological responses to a food portion, mainly for use by an obese or overweight user, or by a user at risk of weight gain. Also provided are user-interactive systems and apparatuses for employing such methods.

Abstract: Systems and methods provide a real-time data display and interface for a network device by loading a page in a browser (115), the page including an engine which is executed in the browser (120) and used to automatically load a definition file (125) from a remote source in response to content within the page. Widgets are instantiated for display in the interface, each making data requests (145) at intervals which are forwarded to one or more servers in communication with the network device. Requested data is received (160) and presented in the interface there by providing the user with dynamically updated data (165). An engine for driving such display comprises executable code configured to instantiate one or more widgets for rendering within the display of the real-time data interface. The engine further includes a reference to a definition file which defines prescribed parameters for one or more of the widgets.

Abstract: Described herein are embodiments for identifying and grouping users of a system based on common interests and/or purchasing goals. In embodiments, one or more items of interest of a user are determined based on user input. A group is formed based on the on the one or more items of interest to the first user. At least a second user is identified based in part on at least one predetermined criterion and based in part on the second user having at least one or more items of interest corresponding to the one or more items of interest of the first user and the one or more items upon which the group was formed. Once the group is formed, the second user is automatically notified of the formation of the group. A third user is identified based on at least a second one of a predetermined criterion and the third user is given access to the group.

Abstract: The invention provides a chimeric CNS targeting polypeptide having a BBB-receptor binding domain and a payload polypeptide domain. The chimeric CNS targeting polypeptide can have a BBB-receptor binding domain consisting of a receptor binding domain from ApoB, ApoE, aprotinin, lipoprotein lipase, PAI-1, pseudomonas exotoxin A, transferrin, ?2-macroglobulin, insulin-like growth factor, insulin, or a functional fragment thereof. Nucleic acids encoding a chimeric CNS targeting polypeptide are also provided. Further provided is a method of delivering a polypeptide to the CNS of an individual. The method consists of administering to the individual an effective amount of a chimeric CNS targeting polypeptide, said chimeric CNS targeting polypeptide comprising a BBB-receptor binding domain and a payload polypeptide domain. The method also can deliver a polypeptide to the lysosomes of CNS cells.

Abstract: A fishing device for indicating a lure strike from fishes is disclosed. The device may be a strike indicator that may include a hollow body filled with trapped air, where the strike indicator includes a tab having an opening formed therein and a grommet made from a hard, durable material seated in the opening. Alternatively, the device may be a fishing lure that may be attachable to a fishing hook and having a hollow body filled with trapped air and an attachment mechanism for attaching the lure to the fishing leader and/or fishing line. For example, the fishing lure may be a fishing fly having a hollow body filled with trapped air. In either embodiment, the device may be made from a lightweight, resilient material, for example ethylene vinyl acetate or other similar thermoplastic material.

Abstract: A component based software program, where each component is based on a component-type. Component-types are created from base classes comprising slot definitions. The slot definitions are identified and stored in a component-type object. One or more components of the component-type are created, each comprising a reference, to a component-type object and a slotmap having storage locations for values associated with property slots definitions, in the component-type object. Values for property slots are entered into components by being placed in the storage locations. Also disclosed is a method for automatically designating unique names to components. One root component is created. Further non-root components are placed within the root component or within other components, so that all components form a tree structure. A component is assigned a unique identification string, comprising a sequential list of all of the component's ancestors and the component's name.

Abstract: A system for facilitating production of information material comprises a plurality of metadata nodes operable to process metadata describing the content of information material, and a data communications network for providing a facility for communicating the metadata between the metadata nodes. The metadata is represented as metadata strings describing the content or attributes associated with the information material. The metadata string includes a Uniform Resource Identifier (URI) providing an address of a storage location of an associated metadata resource. The metadata string is communicable separately from the information material via the network and the associated metadata resource is accessible via the network using the resource identifier. The metadata string can be arranged to provide an indication of parameters describing the information material and identifiers such as UMIDs or the like which facilitate navigation of the information material.

Abstract: An application programmer's interface provides a facility for accessing metadata describing the content or attributes of information material. The application programmer's interface comprises a signalling protocol processor operable to receive a metadata string which includes a resource identifier providing an address of a metadata resource, and a file transfer processor operable to provide access to the metadata resource in accordance with a request from the application program. The signalling protocol processor provides an efficient facility for communicating the metadata string. The metadata string may be in the form of a mark-up language such as XML. The metadata resource may be for example a proxy version of the information material, such as a video proxy if the information material is video. Accordingly, the file transfer processor is arranged to provide efficient access to the video proxy using the address provided with metadata string.

Abstract: A boom section includes a first, a second, a third, and a fourth fiber reinforced thermoset composite material layer and a flex core layer. The first fiber reinforced thermoset composite material layer has glass fibers in a vinyl ester matrix. The second fiber reinforced thermoset composite material layer is disposed over the first composite material layer and has carbon fibers in an epoxy matrix. The flex core layer is disposed over the second composite material layer. The third fiber reinforced thermoset composite material layer is disposed over the flex core layer and has aramid fibers in a vinyl ester matrix. The fourth fiber reinforced thermoset composite material layer is disposed over the third composite material layer and has glass fibers in a vinyl ester matrix.

Abstract: The invention provides a chimeric CNS targeting polypeptide having a BBB-receptor binding domain and a payload polypeptide domain. The chimeric CNS targeting polypeptide can have a BBB-receptor binding domain consisting of a receptor binding domain from ApoB, ApoE, aprotinin, lipoprotein lipase, PAI-1, pseudomonas exotoxin A, transferrin, ?2-macroglobulin, insulin-like growth factor, insulin, or a functional fragment thereof. Nucleic acids encoding a chimeric CNS targeting polypeptide are also provided. Further provided is a method of delivering a polypeptide to the CNS of an individual. The method consists of administering to the individual an effective amount of a chimeric CNS targeting polypeptide, said chimeric CNS targeting polypeptide comprising a BBB-receptor binding domain and a payload polypeptide domain. The method also can deliver a polypeptide to the lysosomes of CNS cells.

Abstract: A method of manufacturing a composite riser section with a liner assembly comprises holding the liner assembly in a horizontal position, bowing the liner assembly upward, and winding resin impregnated fibers about the liner assembly to form a structural composite overwrap. Another method of manufacturing a composite riser with a liner assembly comprises holding the liner assembly in a horizontal position between two supports, and winding resin impregnated fibers about the liner assembly to form a structural composite overwrap. A system for manufacturing a composite riser section with a liner assembly having a longitudinal axis comprises a first support and a second support that hold the liner assembly in a horizontal position therebetween, and a plurality of rollers that rotate the liner assembly about the longitudinal axis.

Abstract: This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs, lentiviral packaging systems, and lentiviral gene delivery systems. Finally, methods of transducing a cell and methods of targeting a gene to a cell or tissue using the disclosed lentiviral vectors and systems are also provided.

Abstract: The invention provides a chimeric CNS targeting polypeptide having a BBB-receptor binding domain and a payload polypeptide domain. The chimeric CNS targeting polypeptide can have a BBB-receptor binding domain consisting of a receptor binding domain from ApoB, ApoE, aprotinin, lipoprotein lipase, PAI-1, pseudomonas exotoxin A, transferrin, ?2-macroglobulin, insulin-like growth factor, insulin, or a functional fragment thereof. Nucleic acids encoding a chimeric CNS targeting polypeptide are also provided. Further provided is a method of delivering a polypeptide to the CNS of an individual. The method consists of administering to the individual an effective amount of a chimeric CNS targeting polypeptide, said chimeric CNS targeting polypeptide comprising a BBB-receptor binding domain and a payload polypeptide domain. The method also can deliver a polypeptide to the lysosomes of CNS cells.

Abstract: The present invention is a boom system comprising a first boom section having a distal end and a proximal end. A second boom section includes a distal end and a proximal end, wherein the proximal end of the second boom section is rotatably coupled to the distal end of the first boom section. At least one of the boom sections is substantially formed from composite materials.