Abstract: The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.

Abstract: Techniques are disclosed for enabling attested end-to-end encryption for transporting sensitive data between devices. In one example, an origination device receives and verifies, in a secure environment, a policy profile that includes an origination key of the origination device and a destination key of a destination device. The origination device generates and seals a data encryption key based on a characteristic of the secure environment. The origination device then encrypts the data encryption key with a public key of the destination device to form an encrypted data encryption key. The origination device then signs the encrypted data encryption key with a private attestation identity key of the origination device. The origination device encrypts the sensitive data with the sealed data encryption key to form encrypted data, and then transmits the signed encrypted data encryption key and the encrypted data to the destination device for subsequent decryption of the encrypted data.

Abstract: In alternative embodiments, provided are compositions such as antibodies, e.g., single chain antibodies, that target 3-repeat (3R) Tau for the treatment of neurodegenerative disorders and taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation, and methods for making and using them. In alternative embodiments, provided are brain-penetrating antibodies that specifically recognize 3R Tau, and methods of using them to treat, ameliorate, prevent or decrease the symptoms of neurodegenerative disorders including taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation.

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for transporting nucleic acids such as oligonucleotides to and across the blood brain barrier (BBB) and into the central nervous system (CNS). In alternative embodiments, provided herein are ApoB11-comprising chimeric or synthetic peptides useful for the delivery of nucleic acids such as oligonucleotides to the CNS for the treatment, prevention or amelioration of a CNS disease, infection or condition, or for diagnostic purposes.

Abstract: In alternative embodiments, provided are compositions such as antibodies, e.g., single chain antibodies, that target 3-repeat (3R) Tau for the treatment of neurodegenerative disorders and taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation, and methods for making and using them. In alternative embodiments, provided are brain-penetrating antibodies that specifically recognize 3R Tau, and methods of using them to treat, ameliorate, prevent or decrease the symptoms of neurodegenerative disorders including taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation.

Abstract: The disclosure is related to searching for a second device to provide a service that a first device is attempting to establish. The first device sends a search profile and a capabilities profile to the second device using near field communication (NFC), the search profile including criteria describing the service the first device is attempting to establish, the capabilities profile including connection capabilities of the first device, receives a score from the second device, the score indicating a closeness of a match between the search profile and the capabilities profile and one or more services and capabilities of the second device, and determines whether to connect with the second device to establish the service based on the received score.

Abstract: A pressure vessel comprising a pipe closed at each end with a novel plug/compression cap, the plug at one end of the pipe having a port for connection to a pressure regulating device.

Abstract: This invention relates to methods of fabricating components of a pressure vessel using a dicyclopentadiene prepolymer formulation in which the purity of the dicyclopentadiene is at least 92% wherein the formulation further comprises a reactive ethylene monomer that renders the prepolymer formulation flowable at ambient temperatures and to pressure vessels that are fabricated by said methods.

Abstract: A pressure vessel comprising a pipe closed at each end with a novel plug/compression cap, the plug at one end of the pipe having a port for connection to a pressure regulating device.

Abstract: A pressure vessel comprising a pipe closed at each end with a novel plug/compression cap, the plug at one end of the pipe having a port for connection to a pressure regulating device.

Abstract: An electrochromic insert adapted to be fitted into an existing window frame allowing an existing window to be retrofit to have the benefits of electrochromics. The insert may have a scaffold that fits into a window frame. Securing the insert to the frame may occur through a variety of ways including a bracket, a flexible tab, a brace, a screw, a bolt, a projection, a detent, and an adhesive. The technology allows for the electrochromic insert to include an electrochromic device, energy collection device, an energy storage device, and an electrochromic device controller. Such a configuration may be considered autonoumous such that it need not draw power from another source.

Abstract: The disclosure is related to searching for a second device to provide a service that a first device is attempting to establish. The first device sends a search profile and a capabilities profile to the second device using near field communication (NFC), the search profile including criteria describing the service the first device is attempting to establish, the capabilities profile including connection capabilities of the first device, receives a score from the second device, the score indicating a closeness of a match between the search profile and the capabilities profile and one or more services and capabilities of the second device, and determines whether to connect with the second device to establish the service based on the received score.

Abstract: In an embodiment, a mobile device is equipped with an application processor configured to execute a HLOS and a secondary processor(s) configured to control sensor(s) coupled to the mobile device. The mobile device monitors the sensor(s) while the mobile device is operating in a low power mode that is characterized by one or more cores of the application processor being in a power collapse state or dormant state. The mobile device identifies a user action based on the monitoring and communicates, while the mobile device continues to operate in the low power mode, with detected proximate device(s) over a local wireless communications interface to request that at least one device action changing a user interface output feature and/or a user environment feature be implemented at the detected proximate device(s).

Abstract: Systems and methods for creating an infrared-control coated thin film device with certain visible light transmittance and infrared reflectance properties are disclosed. The device may be made using various techniques including physical vapor deposition, chemical vapor deposition, thermal evaporation, pulsed laser deposition, sputter deposition, and sol-gel processes. In particular, a pulsed energy microwave plasma enhanced chemical vapor deposition process may be used. Production of the device may occur at speeds greater than 50 Angstroms/second and temperatures lower than 200° C.

Abstract: The technology relates to depositing free-standing electrical devices on a substrate and electrically connecting two or more of the free-standing electrical devices with the aid of a bendable scoring lines. These bendable scoring lines allow the thin-film substrate to be bended, or folded, to form a specific shape. Electrical devices include electrochromic devices or solid state batteries.

Abstract: A fastener assembly includes an insert having a head and a sleeve extending from a bottom surface of the head, with the insert further defining an internal cavity. The head of the insert abuts a first panel with the sleeve extending through a first preformed hole in the first panel. A second panel with a second preformed hole is aligned with the first panel, and a shaft of a fastener pin is inserted through the second preformed hole and into the internal cavity of the insert. Upon rotating the fastener pin, a tee portion at the end of the shaft engages a seat positioned in the internal cavity of the insert. The fastener assembly also includes a compression member positioned around the shaft of the fastener pin that biases the tee portion of the fastener pin into engagement with the seat of the insert.

Abstract: The invention relates to improved metal/composite interfaces, particularly for risers used in offshore oil and gas production to connect a subsea oil well to a surface drilling/production facility. The invention provides a composite hoop structure configured to a bearing surface of a metal groove of metal liner over which axial fibers are laid. The composite hoop structure provides for improved transition of axial, torsional and compressive forces between composite fibers and metal surfaces of the metal liner.