Abstract: An autonomous mobile device (AMD) may move around a physical space performing various tasks. Most of the sensors on the AMD may be directed towards the front and sides of the AMD to facilitate autonomous navigation, interactions with users, and so forth. The AMD may return to a dock to recharge batteries, replenish consumables, transfer payload, and so forth. The AMD uses the sensors to approach the vicinity of the dock. Once in the vicinity, the AMD turns around and backs into the dock. This orientation allows the AMD to continue to operate the forward-facing sensors and interact with users while docked. The AMD uses inductive sensors to detect metallic targets located at particular positions in the dock. Output from the inductive sensors provides information about the relative position of the AMD with respect to the dock and is used to steer the AMD into a desired docked position.

Abstract: A crop harvesting header includes a reel for controlling movement of the crop in the area over the cutter bar to the transport draper carried on two reel mounting arms for upward and downward movement and for moving the reel forwardly and rearwardly along the respective reel mounting arm. The reel has a plurality of reel bats with reel fingers projecting generally radially outwardly from the reel axis where the reel bats are pivotal to vary the angle of the finger driven by a cam track member. An adjustment component defined by a follower in a guide track along one of the arms is responsive to movement of the reel along the arm which causes the cam track member to be angularly advanced and retarded about the reel axis to different adjustment angles in dependence upon the position of the reel along the mounting arms.

Abstract: A medical device (100) includes an insulin pen (102), a pen needle (104) and a force sensor (106). The device also includes a microprocessor (206) to receive a signal from the force sensor (106). Audible and/or visual indicators (218, 220) provide feedback to a user to encourage proper injection technique. The device may also include an adaptor assembly comprising a sensor housing (306) and a first sensor (304) within the sensor housing, and a transfer needle assembly (308), the transfer needle assembly providing a connection (310) for a pen needle, and providing a fluid conduit between the pen needle (312) and the insulin pen (302). A second force sensor (314) is associated with a thumb button of the insulin pen (302).

Abstract: A cooking grill has a firepot configured to burn pelletized fuel fed from an auger, a cooking grate above the firepot, and a double walled enclosure interposing the firepot and the cooking grate and containing and directing flow of combustion gases from the firepot up to the cooking grate.

Abstract: A needle hub (10) for a pen needle is provided with an enlarged surface for contact with the skin of a patient. The enlarged surface is provided with a surface having a dimension and shape to enable a needle or cannula to penetrate the skin to a desired depth and permit substantially the entire exposed length of the needle or cannula to penetrate the skin to the desired depth. The surface of the needle hub can be formed by an inner cone shaped member (26) forming a first contact surface with a surface area of about 1-5 mm2 and an outer ring (28) at a peripheral edge forming a second contact surface with a combined surface area of about 15 to 50 mm2.

Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: A needle-bearing hub for a pen needle is provided with a distal patient-facing side having an enlarged surface for contact with the subject's skin. The enlarged surface is provided with a radius of curvature that increases the likelihood that the needle reaches full injection depth when an injection is performed at an inclined angle with respect to the surface of the skin and with to the desired depth less discomfort to the patient.

Abstract: A sickle cutting system is mounted on a header for forward travel over ground having a standing crop thereon and includes a cutter bar with a plurality of knife guards and two sickle bars driven at a phase angle difference where the drive system has a phase difference control component operable to drive the first and second sickle bars at a first phase angle difference typically at or around 180 degrees difference to minimize vibration when no cutting action is occurring and at a second phase angle difference which can be at or around 90 degrees to minimize variations in loading applied to the drive system when the cutting action is taking place.

Abstract: A header is supported by a pair of hydraulic float cylinders, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration and/or velocity. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. A lift force greater than that required to lift the header can be provided by a lift cylinder and can be opposed in a controlled manner to apply a controlled downforce by the back of the same cylinder or by a separate component.

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae I-XXV, as set forth herein.

Abstract: Provided herein are compositions and methods for treating cancer, treating colitis associated with immune checkpoint inhibitor therapy, colonizing the microbiome, and/or restoring the microbiome, by administering compositions or food products to a subject.

Abstract: A needle hub (10) for a pen needle is provided with an enlarged surface for contact with the skin of a patient. The enlarged surface is provided with a surface having a dimension and shape to enable a needle or cannula to penetrate the skin to a desired depth and permit substantially the entire exposed length of the needle or cannula to penetrate the skin to the desired depth. The surface of the needle hub can be formed by an inner cone shaped member (26) forming a first contact surface with a surface area of about 1-5 mm2 and an outer ring (28) at a peripheral edge forming a second contact surface with a combined surface area of about 15 to 50 mm2.

Abstract: The patient interface may comprise an axis for alignment with an axis of the eye such as an optical axis of the eye. The interface may comprise a guide to allow the interface to move along the axis with the eye, which can inhibit increases in intraocular pressure when the patient is aligned with the laser. The interface may comprise a lock to hold the patient interface at a location along the axis, which can maintain alignment of the patient with the laser eye surgery system. The interface may comprise a plurality of transducers to measure forces to the eye during surgery. The laser eye surgery system can be configured in one or more of many ways to respond to the measured forces. For example, the system may offset the position of laser beam pulses to increase the accuracy of the placement of the beam pulses on the eye.

Abstract: In a crop harvesting machine there is provided a pair of hydraulic float cylinders or springs for a header such as a rotary mower relative to a self-propelled vehicle, where a float spring force is controlled to provide a predetermined lifting force is provided to the header. The spring force is varied in response to detection of ground speed to decrease the lifting force at higher ground speeds. A position sensor is used to generate an indication of movement and/or acceleration. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. In order to reduce static friction so that the system can react quickly, an arrangement is provided for causing relative reciprocating movement in an alternating wave pattern between the piston and cylinder.

Abstract: A floor and an upright sidewall formed from two vertically coaxial components, each component having a floor baffle with a plurality of floor openings defined therein, each floor retained within a respective upright sidewall with a plurality of sidewall openings defined therein. The floor openings and the sidewall openings cooperate between the two coaxial components such that flow of gases through the floor and upright sidewall of the baffle structure is controlled by rotation of the two vertically coaxial components relative to one another.

Abstract: A cooking system having a pellet fueled cooking chamber, a fire chamber held in a fixed relationship with respect to the cooking chamber, and a user adjustable port that selectively allows fluid communication from the fire chamber to the cooking chamber.

Abstract: An power generation structure comprising a portion having a first deck portion comprising an integral multi-stage evaporator system, a second deck portion comprising an integral multi-stage condensing system, a third deck portion housing power generation equipment, a cold water pipe, and a cold water pipe connection. The the evaporator and condenser systems include a multi-stage cascading heat exchange system. Warm water conduits in the first deck portion and cold water conduits in the second deck portion are integral to the structure of the portion of the platform.

Abstract: The patient interface may comprise an axis for alignment with an axis of the eye such as an optical axis of the eye. The interface may comprise a guide to allow the interface to move along the axis with the eye, which can inhibit increases in intraocular pressure when the patient is aligned with the laser. The interface may comprise a lock to hold the patient interface at a location along the axis, which can maintain alignment of the patient with the laser eye surgery system. The interface may comprise a plurality of transducers to measure forces to the eye during surgery. The laser eye surgery system can be configured in one or more of many ways to respond to the measured forces. For example, the system may offset the position of laser beam pulses to increase the accuracy of the placement of the beam pulses on the eye.

Abstract: Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.