Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: A delivery device (10, 40, 100) for delivering a substance, such as an insulin formulation, to a patient includes a storage container (12, 112) containing the insulin formulation, a delivery member (20, 42) connected to the storage container by a fluid pathway for injecting the insulin formulation into the patient for delivering the insulin formulation to the patient at a controlled basal flow rate or bolus flow. The delivery device can have a pump mechanism for delivering the substance to the patient. An activated charcoal adsorbent (51 57, 87) or activated carbon is positioned in the fluid pathway between the storage container and the delivery member for removing at least a portion of a phenolic stabilizing agent from the insulin formulation before delivering to the patient.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: A medical device (100) includes an insulin pen (102), a pen needle (104) and a force sensor (106). The device also includes a microprocessor (206) to receive a signal from the force sensor (106). Audible and/or visual indicators (218, 220) provide feedback to a user to encourage proper injection technique. The device may also include an adaptor assembly comprising a sensor housing (306) and a first sensor (304) within the sensor housing, and a transfer needle assembly (308), the transfer needle assembly providing a connection (310) for a pen needle, and providing a fluid conduit between the pen needle (312) and the insulin pen (302). A second force sensor (314) is associated with a thumb button of the insulin pen (302).

Abstract: In a crop harvesting header with a center section and two wings where each wing is pivotal relative to the center section about a pivot axis extending in a generally forward direction which includes a balance system to maintain a balanced ground force distribution across the width of the header there is provided an automatic adjustment system for maintaining proper balance. The system includes a sensor which repeatedly, over a time period during which the header is operating, detects data relating to the positions, distance from the ground or weight applied to the ground of each wing frame portion, a processor arranged in response to the sensed data to calculate a value representative of the positions and an adjustment mechanism for effecting an adjustment of the balance system in response to the value.

Abstract: A lower housing has a fuel grate situated at a predetermined level within the lower housing for supporting a fuel source. The lower housing has a first wall defining a plurality of air intake openings proximate the level of the fuel grate.

Abstract: Methods, systems, apparatus, and computer program products are provided. In an example embodiment, a communication comprising form fields is received. A form field corresponding to first item information for a first item is identified. A textual item description for the first item is extracted from the form field. A code schedule is accessed and one or more codes are determined for the first item based on the textual item description and the code schedule. An item database is queried to identify second items that are relevant to the first item and a confidence level for each of the codes is determined based on the relevant second items. If a confidence level corresponding to one of the codes is greater than a configurable confidence level, a first code is selected from the codes. An item database is updated to reflect the first code being assigned to the first item.

Abstract: A cooking grate has a first, central grate portion having opposed front and back support edges for engaging with a support ledge in a grill firebox, and second and third side flanking grate portions each with front and rear support edges for engaging with the support ledge.

Abstract: A needle hub (10) for a pen needle is provided with an enlarged surface for contact with the skin of a patient. The enlarged surface is provided with a surface having a dimension and shape to enable a needle or cannula to penetrate the skin to a desired depth and permit substantially the entire exposed length of the needle or cannula to penetrate the skin to the desired depth. The surface of the needle hub can be formed by an inner cone shaped member (26) forming a first contact surface with a surface area of about 1-5 mm2 and an outer ring (28) at a peripheral edge forming a second contact surface with a combined surface area of about 15 to 50 mm2.

Abstract: A system includes a firepot within a cooking chamber, an auger that delivers pelletized fuel into the firepot, and a fan that provides combustion air to the cooking chamber. The fan operates on a periodic basis to maintain the cooking chamber in a state of high relative smoke generation compared to smoke generation that would occur in a steady-state fan operation.

Abstract: A cooking system having a pellet fueled cooking chamber, a fire chamber held in a fixed relationship with respect to the cooking chamber, and a user adjustable port that selectively allows fluid communication from the fire chamber to the cooking chamber.

Abstract: A combustion chamber has an inner wall defining an inner chamber. The inner wall is perforated to admit combustion air into the inner chamber. The combustion chamber has an outer wall defining an outer chamber. The outer wall is perforated to admit combustion air from a pressurized air plenum to the inner wall. The inner and outer wall are spaced apart such that air may flow between the inner and outer walls.

Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: A CD7+ progenitor T cell, a method of producing the CD7+ progenitor T cell, and a method of administering the CD7+ progenitor T cell. The method of producing the CD7+ progenitor T cell includes expanding CD34+ cells.

Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: A header for a crop harvester includes side drapers having a front edge adjacent the cutter bar and carrying crop to a discharge end roller at a center feed draper. A support arrangement carries the rear end of the discharge end roller to define an operating position in which an axis of the discharge end roller is at an angle to an axis of the outer end roller of the side draper with the rear end of the discharge end roller at a height below a height of the rear end of the outer end roller. This provides a main portion of the belt that lies in a common plane defined by an intermediate guide member and the outer end roller and a smaller portion of the draper belt between the guide member and the rear end of the discharge end roller which is twisted downwardly from the common plane.

Abstract: A header is supported by a pair of hydraulic float cylinders, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration and/or velocity. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. A lift force greater than that required to lift the header can be provided by a lift cylinder and can be opposed in a controlled manner to apply a controlled downforce by the back of the same cylinder or by a separate component.

Abstract: A crop harvesting header includes a reel for controlling movement of the crop in the area over the cutter bar to the transport draper carried on two reel mounting arms for upward and downward movement and for moving the reel forwardly and rearwardly along the respective reel mounting arm. The reel has a plurality of reel bats with reel fingers projecting generally radially outwardly from the reel axis where the reel bats are pivotal to vary the angle of the finger driven by a cam track member. An adjustment component defined by a follower in a guide track along one of the arms is responsive to movement of the reel along the arm which causes the cam track member to be angularly advanced and retarded about the reel axis to different adjustment angles in dependence upon the position of the reel along the mounting arms.

Abstract: A header is supported by a pair of hydraulic float cylinders, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration and/or velocity. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. A lift force greater than that required to lift the header can be provided by a lift cylinder and can be opposed in a controlled manner to apply a controlled downforce by the back of the same cylinder or by a separate component.

Abstract: Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.