Abstract: The patient interface may comprise an axis for alignment with an axis of the eye such as an optical axis of the eye. The interface may comprise a guide to allow the interface to move along the axis with the eye, which can inhibit increases in intraocular pressure when the patient is aligned with the laser. The interface may comprise a lock to hold the patient interface at a location along the axis, which can maintain alignment of the patient with the laser eye surgery system. The interface may comprise a plurality of transducers to measure forces to the eye during surgery. The laser eye surgery system can be configured in one or more of many ways to respond to the measured forces. For example, the system may offset the position of laser beam pulses to increase the accuracy of the placement of the beam pulses on the eye.

Abstract: Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: A top of rail (TOR) applicator has a bar positioned in a housing and an exit orifice on the upper portion of the bar for delivering a friction control composition to the crown of a railhead. The upper portion of the bar slopes away from the friction control composition exit orifice. The bar may be composed of an elastomer such as polyurethane. A passageway may extend from an inlet port to the exit orifice. The friction reduction composition is pumped into the inlet port, through the passageway to the exit orifice and then onto the crown of the railhead. The friction reduction composition may be thixotropic.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: Systems and methods for delaying or activating a blowout device in a sampling pipe network of an aspirated smoke detection system are provided. Some systems can include an aspirated smoke detector, a sampling pipe coupled to the aspirated smoke detector, a blowout device coupled to the sampling pipe, and a delay device coupled to the blowout device. Responsive to the aspirated smoke detector detecting a triggering event, the delay device can delay the blowout device from performing a blowout action in the sampling pipe or can instruct the blowout device to perform the blowout action in the sampling pipe.

Abstract: Systems and methods for delaying or activating a blowout device in a sampling pipe network of an aspirated smoke detection system are provided. Some systems can include an aspirated smoke detector, a sampling pipe coupled to the aspirated smoke detector, a blowout device coupled to the sampling pipe, and a delay device coupled to the blowout device. Responsive to the aspirated smoke detector detecting a triggering event, the delay device can delay the blowout device from performing a blowout action in the sampling pipe or can instruct the blowout device to perform the blowout action in the sampling pipe.

Abstract: A header is supported by a pair of hydraulic float cylinders, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration and/or velocity. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. A lift force greater than that required to lift the header can be provided by a lift cylinder and can be opposed in a controlled manner to apply a controlled downforce by the back of the same cylinder or by a separate component.

Abstract: A method and apparatus to make a sterile or aseptic connection between a container of material, such as a fluid, to a terminus using tubes or hoses interspersed with connectors. The system keeps the material container, material, connectors, tubes or hoses and terminus sterile or aseptic from when making connection through to the evacuation of the material container. The system is substantially comprised of connectors to attach tubes or hoses contiguously by making the connection within an enclosure. The enclosure is used to make and keep the portion surrounding the connectors and enclosure attachments in contact with sterilant or sanitizer as a means to make and keep the system sterile or aseptic. It further includes the means of repeating the process after a material container has been depleted followed by the connecting of a new material container to insure any potential contamination has been eradicated before the process of depletion resumes.

Abstract: A sickle cutting system is mounted on a header for forward travel over ground having a standing crop thereon and includes a cutter bar with a plurality of knife guards and at least one sickle bar with a drive system for driving the sickle bar through repeated cycles of reciprocating movement from start-up of the system through to a shut-down. The drive system includes an arrangement to halt the sickle bar on shut-down at a predetermined position of the knife blades relative to the knife guards and preferably the position where the blades lie intermediate two knife guards. The system can be halted by either a physical stop member at the required position or by detecting the position of the sickle bar during operation and causing it to halt the required position. The detection can be carried out by counting pulses generated by markers on a rotary member of the drive system.

Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: The present disclosure provides a strong, flexible catheter shaft for use in a catheter system. The flexible catheter shaft includes a nitinol tube having one or more sets of cuts therein in combination with one or more outer jacket layers. The flexible catheter shaft provides a shaft having sufficient stiffness and kink resistance to allow an operator to advance an electrode basket connected to the flexible catheter shaft through a guide catheter to a target ablation site without causing vessel trauma. The distal tip of the flexible catheter shaft is designed to have sufficient flexibility to reduce any risk of kicking out a guide catheter when tracking the electrode basket around turns in the vasculature of a patient.

Abstract: A header is supported by a pair of hydraulic float cylinders, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration and/or velocity. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. A lift force greater than that required to lift the header can be provided by a lift cylinder and can be opposed in a controlled manner to apply a controlled downforce by the back of the same cylinder or by a separate component.

Abstract: A header is supported by a pair of hydraulic float cylinders, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration and/or velocity. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. A lift force greater than that required to lift the header can be provided by a lift cylinder and can be opposed in a controlled manner to apply a controlled downforce by the back of the same cylinder or by a separate component.

Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: A crop harvesting header having a frame mounted on a propulsion vehicle has a cutter bar carrying a sickle knife and a draper transport. The draper is guided at its front edge by a longitudinally extending rail mounted on the frame for movement therewith. The cutter bar is mounted on the frame at spaced positions by spring blades attached to a fixed beam at the rear which allow up and down flexing movement of the cutter bar relative to the draper engagement member. At the center discharge the cutter bar is carried on shorter blades which are carried on a beam in front of the front draper roller. The small amount of flexing of the cutter bar combines with a balanced three piece header frame to provide effective ground following.

Abstract: In a crop harvesting machine there is provided a pair of hydraulic float cylinders for a header relative to a vehicle, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. In order to reduce static friction so that the system can react quickly, an arrangement is provided for causing relative reciprocating movement in an alternating wave pattern between the piston and cylinder.

Abstract: A workout system 10 as well as playground systems 12 are disclosed. The system 10 and 12 are particularly advantageous because each system 10 or 12 may be secured to a particular terrain via adjustable support members 14 to permit the systems 10 and 12 to support themselves on the terrain without the need of installing cumbersome construction footings to support the systems 10 and 12 onto the ground. Furthermore, the systems 10 and 12 are adapted to adjust the height of the accessories such as horizontal lift up bars 16, parallel lift up bars 18, or monkey bars 20.

Abstract: A wing includes a wing tip hinged to a main wing section. The wing tip includes a stub spar extending past an end of the wing tip. When the wing tip is extended, the stub spar extends into the main wing section to react a moment load across a length of the stub spar.

Abstract: In a crop harvesting machine there is provided a pair of hydraulic float cylinders for a header relative to a vehicle, where a float pressure to the cylinders is directly controlled by an electronic control supplying a variable control signal to a PPRR valve arrangement to maintain the float pressure at a predetermined value. At the set pressure a predetermined lifting force is provided to the header. A position sensor is used to generate an indication of movement and/or acceleration. The electronic control is arranged, in response to changes in the sensor signal, to temporarily change the control signal to vary the lifting force and thus change the dynamic response of the hydraulic float cylinder. In order to reduce static friction so that the system can react quickly, an arrangement is provided for causing relative reciprocating movement in an alternating wave pattern between the piston and cylinder.