Abstract: Systems and methods are provided for decentralized train control. A decentralized train system may include a plurality of wayside control units, configured for placement on or near tracks in a railway network, and one or more train-mounted units, each of which being configured for use in a particular train. Each wayside control unit may obtain information corresponding to each train that passes within its communication range, and provide obtained train-related information to each train-mounted unit passing within its communication range. Each train-mounted unit may configured to receive train-related information from each wayside control unit that comes within its communication range, process the received train-related information, assess based on the processing of the train-related information conditions relating to operation of train within the railway network, and when at least one condition meets one or more particular criteria, perform or cause performing one or more responsive actions.

Abstract: Provided are crystalline forms of nicotinamide riboside, including a Form II of nicotinamide riboside chloride: nicotinamide riboside chloride. Also disclosed are pharmaceutical compositions comprising the crystalline Form II of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline Form II of nicotinamide riboside chloride. The present disclosure also provides methods of preparing the crystalline Form II of nicotinamide riboside chloride. Also provided are a crystalline Form II of nicotinamide riboside chloride that is prepared according to any of the disclosed methods for preparing the crystalline Form II.

Abstract: Systems and methods are provided for rail vehicle signal enforcement and separation control. A vehicle-mounted system for managing operation compliance of a vehicle may include a communication subsystem that includes one or more transponders and one or more communication circuits, configured for communicating signals, and a processing subsystem, that includes at least one processor. The communication subsystem may be configured to communicate signals with one or more fixed reporting stations, with the signals including ultra-wideband (UWB) signals, and with at least some of the signals carrying data pertinent to evaluating vehicle operation compliance. The processing subsystem may be configured to evaluate vehicle operation compliance based on information obtained from at least one signal communicated with at least one reporting station. The processing subsystem may determine a rule for evaluating compliance of the vehicle, and may monitor operation of the vehicle to evaluate compliance with the rule.

Abstract: Examples of wearable systems and methods can use multiple inputs (e.g., gesture, head pose, eye gaze, voice, and/or environmental factors (e.g., location)) to determine a command that should be executed and objects in the three-dimensional (3D) environment that should be operated on. The multiple inputs can also be used by the wearable system to permit a user to interact with text, such as, e.g., composing, selecting, or editing text.

Abstract: Systems and methods are provided for worker protection. A safety vest may be configured to support worker protection receiver function in worker protection systems. Components used in conjunction with the receiver functions may be integrated into the safety vest. The components may include one or more antennas, radio receiver (or transceiver) circuitry, integrated power supply source, indication components, and acknowledgement components. The safety vest may generate safety alerts in response to receiving signals from peer transmitter devices in the worker protection systems.

Abstract: Tetrapeptide linkers for reversibly linking a first compound to a amine-containing second compound are described. Compounds containing the tetrapeptide linkers and methods of using the tetrapeptide linkers are also described.

Abstract: A vacuum bagging system may include a layer assembly defining a fluid flow channel. The layer assembly may include a contact layer mounted to a composite part positionable within an outer mold line (OML) tool. The contact layer may have a contact layer width defined by opposing contact layer side edges. The layer assembly may further include an inner layer mounted to the contact layer and having inner layer side edges located between the contact layer side edges. The fluid flow channel may extend along at least a portion of the composite part to at least one part end. The vacuum bagging system may include an internal vacuum bag positionable against the inner layer. An inner mold line (IML) tool may support the internal vacuum bag. The contact layer width may be less than an IML tool width.

Abstract: We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.

Abstract: RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2? (EPAS1) gene are described. Pharmaceutical compositions comprising one or more Hif2? RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2? RNAi triggers to tumor cells in vivo provides for inhibition of Hif2? gene expression and treatment of cancer.

Abstract: Tetrapeptide linkers for reversibly linking a first compound to a amine-containing second compound are described. Compounds containing the tetrapeptide linkers and methods of using the tetrapeptide linkers are also described.

Abstract: A dual ignition system for aircraft that includes a left and right ignition element, each having a primary module and a secondary module, both operational. A switch mechanism activated by a cockpit control panel selects either the primary mode or the secondary mode for each ignition element. The primary modules could be variable mode modules and the secondary modules could be fixed mode modules. Each module includes a sense magnet responsive to a drive shaft to detect engine position. Each fixed module has a sensor cluster activated by the sense magnet and each variable module has a position encoder activated by the sense magnet.

Abstract: RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2? (EPAS1) gene are described. Pharmaceutical compositions comprising one or more Hif2? RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2? RNAi triggers to tumor cells in vivo provides for inhibition of Hif2? gene expression and treatment of cancer.

Abstract: In one aspect, the present invention is directed to an animal feed composition that is resistant to feeding by birds, the composition comprising a feed pellet and one or more additional animal feed ingredients that is not pelletized. The feed pellet has a higher lipid content (w/w) and a higher starch content (w/w) than each of the one or more additional animal feed ingredients that is not pelletized. The invention also relates to methods for preparing and using the animal feed compositions.

Abstract: Provided are crystalline forms of nicotinamide riboside, including a Form I of nicotinamide riboside chloride according to formula (I). Also disclosed are pharmaceutical compositions comprising the crystalline Form I of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline Form I of nicotinamide riboside chloride. The present disclosure also provides methods of preparing the crystalline Form I of nicotinamide riboside chloride. Also provided are a crystalline Form I of nicotinamide riboside chloride that is prepared according to any of the disclosed methods for preparing the crystalline Form I.

Abstract: The invention is related to a method allowing a prover holding a secret key (x) to prove its identity to a verifier and to prove to this verifier that he is within a predetermined distance of this verifier, said method comprising an initialization phase during which: the prover picks a first nonce (Np) and communicates this first nonce to the verifier; the verifier picks a first random vector (a), a leak function (L?), and a second nonce (Nv); the verifier uses said leak function (L?) to compute a modified secret (x?) depending on the leak (L?(x)) of said secret; the verifier transmits to said prover said leak function and said second nonce; the prover retrieves said first random vector and said modified secret, wherein said first random vector and said modified secret are used by said prover for computing responses (ri) to challenges (ci).

Abstract: A cutting device is configured to attach to a boom arm and includes a saw assembly with a cutting portion configured to cut into a target surface. The cutting device also includes a motor assembly coupled to the saw assembly. The motor assembly has at least two motors configured to rotate the saw assembly about two different axes. The cutting device further comprises a control system operatively coupled to the motor assembly. The control system has at least two sensors coupled to the saw assembly and the control system is configured to position the saw assembly to cut a target surface based on feedback from the at least sensors.

Abstract: Embodiments include a tactile guidance system and various mechanisms for orienting and mounting the tactile guidance system on motorized vehicles such as agricultural spray vehicles. For example, a rod-shaped tactile guidance detector is positioned protruding out sideways from the inner side of each of the front wheels of a self-propelled sprayer vehicle or a tractor. The guidance system is used to detect the location of objects including crops and plants and determine a path of travel.

Abstract: Provided are crystalline forms of nicotinamide riboside, including a Form II of nicotinamide riboside chloride: nicotinamide riboside chloride. Also disclosed are pharmaceutical compositions comprising the crystalline Form II of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline Form II of nicotinamide riboside chloride. The present disclosure also provides methods of preparing the crystalline Form II of nicotinamide riboside chloride. Also provided are a crystalline Form II of nicotinamide riboside chloride that is prepared according to any of the disclosed methods for preparing the crystalline Form II.

Abstract: Embodiments of a boom system for a work vehicle has a first boom member with a plurality of first boom segments aligned lengthwise to extend along a first boom dimension and a second boom member with a plurality of second boom segments aligned lengthwise to extend in the first boom dimension and spaced from the first boom member in a second boom dimension. The boom system also has a union spanning the second boom dimension to couple the first boom member to the second boom member and having a first coupling segment joining consecutive first boom sections together and a second coupling segment joining consecutive second boom sections together.

Abstract: A system for vehicle management includes a control signal interface subsystem and a vehicle-mounted subsystem. Each of these subsystems includes an ultra-wideband (UWB) communications component. The subsystems communicate with each other through the UWB components. The vehicle mounted subsystem interfaces with a braking system of the vehicle. The vehicle mounted subsystem determines the distance between it and the control signal interface subsystem based on the time-of-flight of at least one communication between the subsystems. The vehicle-mounted subsystem can cause the braking system of the vehicle to activate if the distance between the vehicle-mounted subsystem and the control signal interface subsystem is less than a threshold.