Abstract: A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.

Abstract: Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.

Abstract: The invention is directed to a bimetallic catalyst system adapted for the manufacture of xylenes, a process for making said catalyst system, and to the process of manufacture of xylenes using said catalyst system, providing, in embodiments, improved selectivity by at least one of higher ethylene saturation and low xylene loss, decreased susceptibility to poisoning from feedstream impurities, and ability to operate at less severe conditions.

Abstract: The invention is directed to a bimetallic catalyst system adapted for the manufacture of xylenes, a process for making said catalyst system, and to the process of manufacture of xylenes using said catalyst system, providing, in embodiments, improved selectivity by at least one of higher ethylene saturation and low xylene loss, decreased susceptibility to poisoning from feedstream impurities, and ability to operate at less severe conditions.

Abstract: Components, such as a cutting element for an earth-boring drilling tool, include an ultrasonic transducer coupled therewith and configured to transmit an acoustic signal therethrough, and transmit a data signal to a data acquisition unit in response to receiving a returning echo of the acoustic signal. An earth-boring drilling tool comprises a bit body including a plurality of components, an ultrasonic transducer, and a data acquisition unit operably coupled with the ultrasonic transducer. The data acquisition unit may be configured to receive the data signal and determine a temperature distribution of the component based, at least in part, on a time-of-flight of the acoustic signal and the returning echoes. Methods for forming such components and measuring a temperature of such components may relate to coupling and implementing such an ultrasonic transducer with a component of an earth-boring drilling tool.

Abstract: The invention is directed to a bimetallic catalyst system adapted for the manufacture of xylenes, a process for making said catalyst system, and to the process of manufacture of xylenes using said catalyst system, providing, in embodiments, improved selectivity by at least one of higher ethylene saturation and low xylene loss, decreased susceptibility to poisoning from feedstream impurities, and ability to operate at less severe conditions.

Abstract: According to an exemplary embodiment of this disclosure, a computer-implemented method includes capturing a plurality of images from a presentation. Each of the plurality of images is associated with a unique identifier. The unique identifiers are transmitted to one or more remote audience modules. The plurality of images are then transmitted to the audience modules. With a computer processor, a first image from the plurality of images is identified as a next active image. Indications are received from the one or more of the audience modules that the next active image has been received. The audience modules are instructed to update their displays from a current active image to the next active image, after the indications are received.

Abstract: According to an exemplary embodiment of this disclosure, a computer-implemented method includes capturing a plurality of images from a presentation. Each of the plurality of images is associated with a unique identifier. The unique identifiers are transmitted to one or more remote audience modules. The plurality of images are then transmitted to the audience modules. With a computer processor, a first image from the plurality of images is identified as a next active image. Indications are received from the one or more of the audience modules that the next active image has been received. The audience modules are instructed to update their displays from a current active image to the next active image, after the indications are received.

Abstract: An adjustable immobilizing joint brace has a pair of opposed, spaced apart first supports for supporting and immobilizing a joint. Each first support has a pair of first joint holes proximate a first end. One of the holes of the pair of first joint holes is spaced further from the first end of the first support than the other hole. A pair of opposed, spaced apart second supports has two opposed sides. Each second support has a pair of second joint holes proximate a joint end. The pair of second joint holes can be aligned with and attached to the pair of first joint holes on either side of the first support to form different angles of attachment between the first supports and the second supports depending on the orientation of the first supports relative to the orientation of the second supports.

Abstract: A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.

Abstract: Apparatus and methods for therapy delivery are disclosed. In one embodiment, a therapy delivery system includes a plurality of movable components including a radiation therapy nozzle and a patient pod for holding a patient, a patient registration module for determining a desired position of at least one of the plurality of movable components, and a motion control module for coordinating the movement of the least one of the plurality of movable components from a current position to the desired position.

Abstract: The invention is directed to a multimetallic catalyst and its use in a reactor system in a C9+ aromatics conversion process in order to reduce the saturation of aromatic species, reduce the production of C6+ non-aromatics byproducts, and achieve higher benzene purity. The multimetallic catalyst exhibits improved selectivity towards aromatic hydrocarbons in comparison to a traditional Pt/ZSM-5 catalyst and comprises ZSM-5, a Group 6-10 metal, and an additional metal not in Group 6-10. The C9+ aromatics conversion reactor system comprises a top bed containing the multimetallic catalyst for dealkylation of ethyl and propyl side chains, a second bed containing a catalyst comprising a hydrogenation component for transalkylation, and an optional third bed containing a catalyst without a hydrogenation component to convert non-aromatic hydrocarbons to gas products.

Abstract: A computer-implemented method for archiving a live media presentation includes archiving the live media presentation as it is being streamed from a live server, wherein the archiving includes recording the live media presentation in fixed-length segments. A segment name is associated with each of the segments, wherein each of the segment names includes a time stamp. The fixed-length segments are stored on a video on-demand (VOD) server. A manifest is generated that describes at least a portion of the live media presentation and identifies a uniform resource locator (URL) to be used by a client device to access a first one of the segments, wherein the URL includes the segment name of the first segment.

Abstract: Components, such as a cutting element for an earth-boring drilling tool include an ultrasonic transducer coupled therewith, and configured to transmit an acoustic signal therethrough, and transmit a data signal to a data acquisition unit in response to receiving a returning echo of the acoustic signals. An earth-boring drilling tool, comprises a bit body including a plurality of components, an ultrasonic transducer, and a data acquisition unit operably coupled with the ultrasonic transducer. The data acquisition unit may be configured to receive the data signal and determine a temperature distribution of the component based, at least in part, on a time-of-flight of the acoustic signals and the returning echoes. Methods for forming such components and measuring a temperature of such components may relate to coupling and implementing such an ultrasonic transducer with a component of an earth-boring drilling tool.

Abstract: In a process for producing mono-cycloalkyl-substituted aromatic compound, benzene and cyclic monoolefin are contacted with a catalyst under alkylation conditions to produce an effluent containing mono-cycloalkyl-substituted aromatic compound. The catalyst comprises a molecular sieve.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

Abstract: A process is described for producing a catalyst composition comprising an iridium component dispersed on a support. In the process, silica-containing support is treated with an iridium compound and an organic compound comprising an amino group to form an organic iridium complex on the support. The treated support is then heated in an oxidizing atmosphere at a temperature of about 325° C. to about 475° C. to partially decompose the organic metal complex on the support. The treated support is then heated in a reducing atmosphere at a temperature of about 350° C. to about 500° C. to convert the partially decomposed organic iridium complex into the desired iridium component.

Abstract: Methods of forming earth-boring tools include using a plasma spray device to gouge at least one recess through a hardfacing material and into a body. At least a portion of the recess may define a cutting element pocket in which a cutting element may be received and bonded. The recess formed using the plasma spray device optionally may be further machined to form the cutting element pocket. Earth-boring tools are fabricated using such methods.

Abstract: The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

Abstract: Compositions and methods for the treatment of norovirus infection are disclosed.