Abstract: The invention concerns a method of making a catalyst adapted for isomerization of xylenes.

Abstract: A high frequency alternating current medical device and method of using such is disclosed. High frequency alternating current medical device comprises a power source, an electric field generator, a self-limiting conductive material electrical component, at least one probe or needle-type projection, and at least two conductive segments located on probe or needle-type projection. At least two conductive segments are electrically connected to electric field generator so that an electric field is created between conductive segments, which induces an electrical current, which generates heat, and causes a certain desired precise cell injury. Self-limiting conductive material electrical component allows such precise cell injury because it limits electrical current through target tissue. Invention may be used in medical, dental, or veterinary applications. Exemplary embodiments include cosmetic applications, treatment of wrinkles, remodeling of subcutaneous tissue, treatment of muscle spasms, and others.

Abstract: The present invention relates to 1,4-Substituted Piperazine Derivatives, compositions comprising one or more 1,4-Substituted Piperazine Derivatives, and methods of using the 1,4-Substituted Piperazine Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

Abstract: Compounds of Formula I are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Abstract: In a process for producing sec-butylbenzene, a C4 olefinic hydrocarbon feedstock comprising isobutene and at least one n-butene is contacted with methanol and/or water in the presence of an acid catalyst to selectively oxygenate isobutene to produce an effluent stream rich in n-butene and containing less isobutene than the feedstock. The effluent stream is then contacted with benzene under alkylation conditions and in the presence of an alkylation catalyst to produce alkylation stream comprising sec-butylbenzene.

Abstract: In a process for reducing the level of tert-butylbenzene in a mixed butylbenzene feed comprising tert-butylbenzene and sec-butylbenzene, the feed is contacted under dealkylation conditions with a catalyst system comprising a dealkylation catalyst whereby the tert-butylbenzene is selectively dealkylated to produce an effluent stream which comprises benzene and which has a lower concentration of tert-butylbenzene than said feed.

Abstract: A disk spindle assembly cartridge is described. The disk spindle assembly cartridge includes a base, a spindle motor attached to the base, a disk seated on the spindle motor, a disk clamp attached to the spindle motor, wherein the disk clamp secures the disk to the spindle motor, and a cover attached to the base. The base is configured to detachably mount a head stack assembly cartridge, where the disk is accessible to a head stack assembly pivotally mounted in the head stack assembly cartridge via an opening defined by the base and the cover.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

Abstract: Process for the preparation of a catalyst suitable for use in a naphtha reforming process, the process including providing a Y zeolite with an initial SiO2:Al2O3 molar ratio of at least 150, introducing the Y zeolite to a binder to form an intermediate composition, extruding the intermediate composition, reducing the alpha acidity of the extruded composition to provide a low acid composition, and introducing a noble metal to the low acid composition. Processes and systems of converting naphtha to a higher-octane hydrocarbon supply using catalysts, as prepared herein, are also disclosed.

Abstract: The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

Abstract: In one aspect, a method of making a drill bit is disclosed that includes selecting a drill bit configuration, obtaining a stress map for the drill bit configuration relating to a drilling operation, performing a mechanical test with an actual drill bit having the selected configuration, and selecting a location on a surface of the drill bit for installing a sensor thereat based on a location of low stress from the stress map and results of the mechanical test, and placing a sensor at the selected location.

Abstract: The present disclosure relates to techniques for potentially increasing the reliability and/or stability of systems having virtual machines that support multiple modes of execution. For example, as described herein, a virtual machine partitions a plurality of program instructions into a plurality of traces for execution by a virtual machine operating on a computing device, wherein the virtual machine has first and second modes of execution, and wherein each of the plurality of traces comprises one or more of the plurality of program instructions. The virtual machine applies the second mode of execution to a first trace in the plurality of traces and determines an error condition that is caused by the application of the second mode of execution to the first trace. After determining the error condition, the virtual machine applies the first mode of execution to the first trace to recover the virtual machine from the error condition.

Abstract: The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

Abstract: Removable actuator assemblies for testing head gimbal assemblies of a storage device are provided. One such removable test assembly for a head gimbal assembly (HGA) includes an actuator base including at least one guide pin, a shoe assembly including a body including a first end portion opposite to a second end portion, a first attachment means for releaseably coupling the shoe assembly with the actuator base, the first attachment means positioned along the first end portion and including at least one hole in the body configured to receive the at least one guide pin, and a locking cam configured to rotate such that a portion of the cam is positioned over a portion of the at least one hole, and a second attachment means for releaseably coupling the shoe assembly with the HGA, the second attachment means positioned along the second end portion.

Abstract: A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.

Abstract: Components, such as a cutting element for an earth-boring drilling tool include an ultrasonic transducer coupled therewith, and configured to transmit an acoustic signal therethrough, and transmit a data signal to a data acquisition unit in response to receiving a returning echo of the acoustic signals. An earth-boring drilling tool, comprises a bit body including a plurality of components, an ultrasonic transducer, and a data acquisition unit operably coupled with the ultrasonic transducer. The data acquisition unit may be configured to receive the data signal and determine a temperature distribution of the component based, at least in part, on a time-of-flight of the acoustic signals and the returning echoes. Methods for forming such components and measuring a temperature of such components may relate to coupling and implementing such an ultrasonic transducer with a component of an earth-boring drilling tool.

Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are contacted under hydroalkylation conditions with a catalyst system comprising a MCM-22 family molecular sieve and at least one hydrogenation metal. The conditions comprise a temperature of about 140° C. to about 175° C., a pressure of about 135 psig to about 175 psig (931 kPag to 1207 kPag), a hydrogen to benzene molar ratio of about 0.30 to about 0.65 and a weight hourly space velocity of benzene of about 0.26 to about 1.05 hr?1.

Abstract: The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract: A process is described for producing a catalyst composition comprising an iridium component dispersed on a support. In the process, silica-containing support is treated with an iridium compound and an organic compound comprising an amino group to form an organic iridium complex on the support. The treated support is then heated in an oxidizing atmosphere at a temperature of about 325° C. to about 475° C. to partially decompose the organic metal complex on the support. The treated support is then heated in a reducing atmosphere at a temperature of about 350° C. to about 500° C. to convert the partially decomposed organic iridium complex into the desired iridium component.