Abstract: A device is provided herein for deploying a suture in a puncture through a vessel wall of a blood vessel, the puncture disposed within a tissue tract of a patient body. The device includes a shaft suitable for insertion along the tissue tract and into the vessel through a puncture, a plurality of needles, each needle having a proximal end and a distal end suitable for forming a needle path through the vessel wall, wires associated with each needle, each wire having a distal end and a proximal end, and hooks coupled to each of the distal ends of each wire, each hook being configured to anchor the wire to an interior portion of the vessel wall.

Abstract: A method for encoding a carrier signal in a video signal, the video signal having one or more frames, the frames each having a first field and a second field, the first field and the second field of each frame having a plurality of scan lines, each having a plurality of pixels with an intensity value indicating brightness, the method comprising selectively designating the plurality of scan lines of the first field of the one or more frames as up lines or down lines, calculating an optimum amount of adjustment to the pixels of the up lines and the down lines, and selectively increasing the intensity value of pixels of the up lines and decreasing the intensity value of pixels of the down lines by the optimum amount of adjustment thereby modulating the video signal with a carrier signal and creating a modulated video signal.

Abstract: An apparatus for placement into an opening formed in a wall of a body lumen to deploy a closure element. The apparatus comprising a housing having a handle portion formed at a distal end, the handle portion configured to be engaged by a user when advancing the housing to deploy the closure element. A locator assembly and a carrier assembly are at least partially received in the housing. The locator assembly can have one or more expansion members that can selectably contact the wall of the body lumen and a proximal end configured to cooperate with a portion of a locator control system operable to expand the one or more expansion members. A triggering system cooperates with the locator assembly and is moveable toward the one or more expansion members of the locator assembly upon the locator control system being operated to expand the one or more expansion members.

Abstract: The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

Abstract: An apparatus for placement into an opening formed in a wall of a body lumen to deploy a closure element. The apparatus comprising a housing having a handle portion formed at a distal end, the handle portion configured to be engaged by a user when advancing the housing to deploy the closure element. A locator assembly and a carrier assembly are at least partially received in the housing. The locator assembly can have one or more expansion members that can selectably contact the wall of the body lumen and a proximal end configured to cooperate with a portion of a locator control system operable to expand the one or more expansion members. A triggering system cooperates with the locator assembly and is moveable toward the one or more expansion members of the locator assembly upon the locator control system being operated to expand the one or more expansion members.

Abstract: An optimized pseudo-random period pattern can reduce audible noise in a system that includes an inverter circuit configured to provide power to an electric machine. A system can include a PWM optimization module (POM) comprising the PPP. A carrier period for a carrier signal used to provide PWM inverter drive signals can be selected in accordance with the PPP. The PPP can be expressed as an array of 200-400 elements, each element a period belonging to a finite set of 2 or more predetermined periods. A period can be selected by index from the array, and the index incremented to progress through the PPP, which can be repeated upon its completion. The PPP can be optimized to reduce audible noise while mitigating inverter losses. Modeling techniques can determine the number of array elements, the number of possible periods, and the period values that optimize the PPP.

Abstract: An interferometer has its performance enhanced by being suspended in a housing that is optionally evacuated. The frame that supports the interferometer is secured to a cover for the housing with a plurality of studs having mechanical vibration isolators. The frame comprises a support flange with a foam layer beneath the interferometer. An optics tray is disposed above the interferometer and holds the assembly to the support flange. The fibers that are connected to the interferometer enter the side of the housing and the entry is sealed off to allow the interior of the housing to be evacuated.

Abstract: The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

Abstract: An entertainment device is configured to receive a limited range wireless signal from at least one other entertainment device when adjacently arranged in close physical proximity to at least one other entertainment device, and to responsively operate in a first mode or a second mode based on whether the other entertainment device is adjacent a first side or second side. In the first mode, the entertainment device initiates one or more wireless activation signals to control an audio/visual element of another entertainment device. In the second mode, the entertainment device receives wireless activation signals from another entertainment device to control activation of an audio/visual element of the receiving entertainment device. Each device is interchangeable between operation in the first mode of controlling at least one other entertainment device and the second mode of being controlled by another entertainment device based on position of one entertainment device relative to the other.

Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.

Abstract: A method, apparatus and system for signal modulation. A plurality of pixels are selected in a pattern such that a first pixel group of the plurality of pixels is unpaired with a second pixel group of the plurality of pixels throughout the pattern in a portion of a video signal. The intensity of the plurality of the pixels is altered at a constant magnitude in the portion of the video signal pursuant to the pattern in a substantially invisible way.

Abstract: An apparatus for placement into an opening formed in a wall of a body lumen to deploy a closure element. The apparatus comprising a housing having a handle portion formed at a distal end, the handle portion configured to be engaged by a user when advancing the housing to deploy the closure element. A locator assembly and a carrier assembly are at least partially received in the housing. The locator assembly can have one or more expansion members that can selectably contact the wall of the body lumen and a proximal end configured to cooperate with a portion of a locator control system operable to expand the one or more expansion members. A triggering system cooperates with the locator assembly and is moveable toward the one or more expansion members of the locator assembly upon the locator control system being operated to expand the one or more expansion members.

Abstract: An apparatus for placement into an opening formed in a wall of a body lumen to deploy a closure element. The apparatus comprising a housing having a handle portion formed at a distal end, the handle portion configured to be engaged by a user when advancing the housing to deploy the closure element. A locator assembly and a carrier assembly are at least partially received in the housing. The locator assembly can have one or more expansion members that can selectably contact the wall of the body lumen and a proximal end configured to cooperate with a portion of a locator control system operable to expand the one or more expansion members. A triggering system cooperates with the locator assembly and is moveable toward the one or more expansion members of the locator assembly upon the locator control system being operated to expand the one or more expansion members.

Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.

Abstract: A method for modulating a video signal. Frames of a plurality of frames are selected for modulation. A first magnitude alternation pattern is designated for each of a first area of a field of the selected frames. A second magnitude alternation pattern is designated for each of a second area of the field of the selected frames. The intensity of a plurality of pixels of a plurality of scan lines of the field of the selected frames is altered as designated by either the first magnitude alternation pattern or the second magnitude alternation pattern.

Abstract: A fiber optic cable includes: a first elongated body, the first elongated body having a longitudinal axis; an elongated sleeve disposed coaxially with the first elongated body, the elongated sleeve including a plurality of second elongated bodies wrapped around an exterior surface of the first elongated body; and at least one elongated fiber optic component disposed inside of and coaxially with at least one of the first elongated body and a second elongated body.