Abstract: A method executed by at least one server, comprising: receiving, from a first monitored system comprising an internal combustion engine and a first sensor, a first signal associated with a first occurrence and a second occurrence of an internal combustion engine event and first measurement data of the first sensor; determining a first measurement from the first measurement data and a second measurement from the first measurement data based on the first and second occurrences, respectively; determining a reference measurement; determining a first reference deviation; determining a second reference deviation; after determining the first reference deviation is less than a first reference threshold and the second reference deviation is less than a second reference threshold, determining a measurement deviation; comparing the measurement deviation to a measurement threshold; and after determining the measurement deviation satisfies the measurement threshold, determining a first exhibited useful life of the first s

Abstract: In example implementations, the end cap of a vertical panel door stacking system is coupled to a panel. The end cap includes a body portion, a cam lever to rotate around an axis to generate a lift force to lift and separate an adjacent panel of a plurality of panels of the vertical panel door stacking system, a first track wheel, a second track wheel, and a third track wheel.

Abstract: A medical waste fluid collection cart may include a container assembly and a suction tube having a lumen extending through the suction tube. The suction tube may communicate with the container to deposit waste fluid from a surgical site in the container. The container assembly may include a container, a base forming a bottom of the container, and a lid assembly. The base may include an interior surface defining a draining opening. The interior surface may extend along a ramped path toward the drain opening. The lid assembly may include a lid ring and a lid capable of engaging each other with a twist lock mechanism. The lid ring may engage the container and the lid may cover at least part of a central opening to the container. The container may have a window and a tinting assembly. The container assembly may have a vacuum level detection system.

Abstract: A variety of active cover plate configurations with prongs configured to contact side screw terminals of electrical receptacles are described.

Abstract: Described herein are pumps that linearly reciprocate to assist with circulating blood within the body of a patient. Red blood cell damage may be avoided or minimized by such linear pump movement. The linearly reciprocating movement may also generate a pulsatile pumping cycle that mimics the natural pumping cycle of the heart. The pumps may be configured to reside at various body locations. For example, the pumps may be situated within the right ventricle, the left ventricle, the ascending aorta, the descending aorta, the thoracic aorta, or the abdominal aorta. In some instances, the pump may be deployed within the venous circulation. In other instances, the pump may reside outside the patient.

Abstract: A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel.

Abstract: A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.

Abstract: A vehicle includes an engine and a curb cutting assembly. The curb cutting assembly is mounted on the chassis. The curb cutting assembly includes a main beam, a saw assembly, vertical cylinders, horizontal cylinders, pivot cylinders, and a pump. The vertical cylinders are configured to raise and lower the main beam in a vertical direction. The horizontal cylinders are configured to extend or retract the main beam in a lateral direction. The pivot cylinders are configured to extend or retract to pivot the main beam, the horizontal cylinders, and the vertical cylinders about a longitudinal direction. The pump is configured to be driven by the engine and pressurize hydraulic fluid for the saw assembly, the vertical cylinders, the horizontal cylinders, and the pivot cylinders.

Abstract: A three-dimensional printing system can include a particulate build material including metal particles. The three-dimensional printing system can include a binding agent applicator fluidly coupled or coupleable to a binding agent. The three-dimensional printing system can include a suppression agent applicator fluidly coupled or coupleable to a melting point suppression agent, the melting point suppression agent including a dispersion of melting point suppression particles. The three-dimensional printing system can include a hardware controller to generate a command to direct the binding agent applicator to iteratively apply the binding agent to the particulate build material to form individually patterned object layers of a green body object, and direct the suppression agent applicator to iteratively apply the melting point suppression agent to a discrete location of the individually patterned object layers. The discrete location can include a discrete surface region of the green body object.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (II) and compounds of formula (III), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Steering responses for a lean-to-steer device can be provided by controlling the steering angle of at least one wheel by a steering actuator that is operated by a controller. The controller receives signals that are indicative to the current operating conditions and adjusts the steering angle for at least one wheel responsive to the signals.

Abstract: Described herein are pumps that linearly reciprocate to assist with circulating blood within the body of a patient. Red blood cell damage may be avoided or minimized by such linear pump movement. The linearly reciprocating movement may also generate a pulsatile pumping cycle that mimics the natural pumping cycle of the heart. The pumps may be configured to reside at various body locations. For example, the pumps may be situated within the right ventricle, the left ventricle, the ascending aorta, the descending aorta, the thoracic aorta, or the abdominal aorta. In some instances, the pump may reside outside the patient.

Abstract: A lock module comprising a housing, a lock pawl, and an actuator. The lock pawl may be moveable between an extended position and a retracted position, wherein the lock pawl extends from the housing by a greater distance in the extended position than in the retracted position. The actuator may be configured to selectively couple to the lock pawl, the lock module being in a locked configuration when the actuator is coupled to the lock pawl. The lock pawl may be configured to move in a first direction as a closure moves from a first position to a second position and the lock pawl may be configured to move in a second direction as the closure moves from the second position to the first position. The first direction may be opposite the second direction. The lock pawl may be configured to block movement of the closure when the lock module is in the locked configuration.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: Processes for producing n-heptane from a mixture of 1-hexene and 1-octene in the presence of a suitable isomerization-metathesis catalyst followed by a hydrogenation step are disclosed. Integrated manufacturing systems for producing n-heptane with minimal waste also are disclosed.

Abstract: User interface techniques provide user vocalists with mechanisms for seeding subsequent performances by other users (e.g., joiners). A seed may be a full-length seed spanning much or all of a pre-existing audio (or audiovisual) work and mixing, to seed further contributions of one or more joiners, a user's captured media content for at least some portions of the audio (or audiovisual) work. A short seed may span less than all (and in some cases, much less than all) of the audio (or audiovisual) work. For example, a verse, chorus, refrain, hook or other limited “chunk” of an audio (or audiovisual) work may constitute a seed. A seeding user's call invites other users to join the full-length or short-form seed by singing along, singing a particular vocal part or musical section, singing harmony or other duet part, rapping, talking, clapping, recording video, adding a video clip from camera roll, etc.

Abstract: A medical waste fluid collection cart may include a container assembly and a suction tube having a lumen extending through the suction tube. The suction tube may communicate with the container to deposit waste fluid from a surgical site in the container. The container assembly may include a container, a base forming a bottom of the container, and a lid assembly. The base may include an interior surface defining a draining opening. The interior surface may extend along a ramped path toward the drain opening. The lid assembly may include a lid ring and a lid capable of engaging each other with a twist lock mechanism. The lid ring may engage the container and the lid may cover at least part of a central opening to the container. The container may have a window and a tinting assembly. The container assembly may have a vacuum level detection system.

Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: At least one server comprising at least one processor coupled to at least one memory storing instructions. The server can receive a first signal from a first monitored system comprising an internal combustion engine and a first sensor, the first signal associated with a first occurrence of an internal combustion engine event, a second occurrence of the internal combustion engine event, and first measurement data of the first sensor. The server can determine a first measurement from the first measurement data. The server can determine a second measurement from the first measurement data. The server can determine a measurement deviation between the first measurement and the second measurement. The server can compare the measurement deviation to a stored measurement threshold. The server can determine a first exhibited useful life of the first sensor based on the measurement deviation and at least one of the first measurement or the second measurement.