Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: An endoscope comprises a handpiece housing, an elongate flexible shaft extending from the handpiece housing, a pull wire extending from the handpiece housing into the elongate flexible shaft, and a tensioning mechanism configured to adjust tension in the pull wire. A method for adjusting tension in a pull wire of a controller for an endoscope comprises preparing an endoscope for use before a procedure, adjusting tension in a pull wire for deflecting a flexible elongate shaft of the endoscope to reduce knob dwell, and performing an endoscopic procedure with the endoscope.

Abstract: A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel.

Abstract: A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.

Abstract: Systems and methods for continuous injection of fluid, in some examples these apparatuses may include a manifold, a pair of reciprocating pistons, and an actuation control that may apply both suction (aspiration) and injection of fluid as part of the same actuation. The systems and methods may be configured to simplify the operation of a continuous fluid injection system, including one that aspirated prior, to injection to confirm the absence/presence of blood.

Abstract: A vertical panel door stacking system for a door having panels with end caps coupled thereto. The end caps include a body portion, a cam lever to rotate around an axis to generate a lift force to lift and separate an adjacent pair of panels of the panels of the door, a first track wheel, a second track wheel, and a third track wheel. The track wheels interact with a track system to guide movement of the door panels between a closed position and an open position.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A digital display of an active window is provided. An application, separate from the application providing the digital display, is capable of identifying an artifact in the active window of the digital display without a priori knowledge or an application programming interface to the application providing the digital display. The artifacts may be alpha-numeric artifacts or non-alpha-numeric artifacts. The active window may be examined in multiple dimensions including 2 dimensions, 3 dimensions or more. Alpha-numeric artifacts, once identified, are pre-processed to remove anti-aliasing to allow for processor optical recognition.

Abstract: In example implementations, a horizontal door guide for a vertically stacking door is provided. The horizontal door guide includes a first track and a second track to vertically stack panels of a door along a horizontal line, a drive shaft coupled to a bottom most panel to lift the door vertically, a Geneva drive shaft coupled to the drive shaft, and a lifting cam coupled to the Geneva drive shaft, wherein the lifting cam comprises a rotating lever to separate and lift adjacent panels of the door as the door is opened in a vertical direction by the drive shaft and to push panels into the first track and the second track.

Abstract: Described herein are devices and methods for pumping blood in a patient in need of circulatory assistance or a replacement heart. Instead of providing a temporary solution for these patients, the devices may be permanently implanted. The devices linearly reciprocate a shuttle within a housing to move blood into and out of the housing, and rotate the shuttle to selectively direct the movement of blood into and out of a plurality of ports in the housing.

Abstract: Disclosed herein is a web user experience improvement for digital magazines. A digital magazine viewing platform is integrated with a digital magazine publishing platform including features that leverage the integration including user interface arrangement based on viewing habits and ripped content that is insertable into draft digital magazine documents. In some embodiments, a machine learning model categorizes magazine styles and present publishing features based on those magazines viewed or subscribed to by a given user.

Abstract: An under hood storage system of a vehicle includes an under hood storage compartment located in an under hood area of a vehicle, and a hood assembly that, when in a closed position closes the under hood storage compartment. The hood assembly includes an under hood panel having a first portion formed from a first material, and a second portion surrounding the first portion defining an outer perimeter of the under hood panel. The second portion is formed from a second material softer than the first material. One or more attachment features secure the under hood panel to the hood assembly. The under hood panel interacts with the under hood storage compartment to close the under hood storage compartment.

Abstract: Processes for producing n-heptane from a mixture of 1-hexene and 1-octene in the presence of a suitable isomerization-metathesis catalyst followed by a hydrogenation step are disclosed. Integrated manufacturing systems for producing n-heptane with minimal waste also are disclosed.

Abstract: A variety of active cover plate configurations with prongs configured to contact side screw terminals of electrical receptacles are described.

Abstract: At least one server comprising at least one processor coupled to at least one memory storing instructions. The server can receive a first signal from a first monitored system comprising an internal combustion engine and a first sensor, the first signal associated with a first occurrence of an internal combustion engine event, a second occurrence of the internal combustion engine event, and first measurement data of the first sensor. The server can determine a first measurement from the first measurement data. The server can determine a second measurement from the first measurement data. The server can determine a measurement deviation between the first measurement and the second measurement. The server can compare the measurement deviation to a stored measurement threshold. The server can determine a first exhibited useful life of the first sensor based on the measurement deviation and at least one of the first measurement or the second measurement.

Abstract: A system for physical rehabilitation is disclosed. The system comprises a plurality of motors configured to be coupled to a ceiling, and a plurality of cable portions. Each cable portion is connected at a first end to a motor, among the plurality of motors, and connected at a second end to a connector element for attaching to a patient. The system also comprises a controller in operative communication with the plurality of motors to move the connector element in relation to a staircase. The controller is configured to adjust one or both of position and speed of the connector element based on tracked kinematics of the patient as the patient moves along the staircase.

Abstract: In example implementations, a track system of a vertically stacking door includes a vertical track, a track coupling coupled to the vertical track, a first curved track portion coupled to the track coupling, a second curved track portion coupled to the track coupling, and a ramp coupled to the vertical track. The ramp interacts with a cam lever to separate adjacent panels of the vertically stacking door.