Abstract: A variety of active units that sense environmental variables and take various actions are described. In one embodiment, an active unit includes at least one sensor to detect a change in an environmental variable and generate a sensor signal and an action module configured to influence the environmental. The active unit may also include a communication module and a processor module configured to accept the sensor signal and determine if the environmental variable exceeds a threshold and to instruct the action module not to take action to influence the environmental variable, and instruct the communication module to transmit a signal to other active units that the environmental variable has exceeded the threshold.

Abstract: Method and apparatus for a laterally extendable backup light system for placement on the trailer of the 18-wheeler tractor trailer truck. The backup light would be mounted underneath an outer edge of the trailer of the tractor-trailer so that it would be extendable laterally away from the edge of the trailer so that the light portion would extend far enough outwardly to travel beyond the outer edge of the trailer so that the beam of light emanating therefrom would illuminate the area behind the rear of the trailer. A linear actuator controlled wirelessly or via hardwire by the driver of the truck would actuate the light portion of the device so that the light portion would extend from an enclosure beyond the edge of the trailer of the truck-trailer or would be retracted back into the enclosure.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: Systems and methods disclosed herein include a robotic arm positioned outside of the vehicle. The robotic arm may include an end effector configured as a cleaning implement for cleaning a surface in the interior of the vehicle. The system may include a first camera configured to determine a position of the vehicle with respect to a reference point. The system may include a second camera configured to scan the interior of the vehicle. The second system may include a first controller configured to create and/or modify a tool path to execute a cleaning operation, based on the scan, and to send instructions to the robotic arm to execute the cleaning operation in accordance with the created and/or modified tool path.

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.

Abstract: The present disclosure relates to an electromechanical system comprising a toothed rotor and a stator segment. The stator segment comprises an armature coil defining a coil interior. The stator segment further comprises first and second stator portions, each stator portion comprising connected inner and outer radially extending poles. Each of the inner poles passes through the coil interior and each of the outer poles is provided outside of the coil interior. The stator segment further comprises a bridge spacing the stator portions and the bridge comprises a magnetic field generator arranged to generate a magnetic field between the stator portions.

Abstract: Disclosed herein is a web user experience improvement for digital magazines. A digital magazine viewing platform is integrated with a digital magazine publishing platform including features that leverage the integration including user interface arrangement based on viewing habits and ripped content that is insertable into draft digital magazine documents. In some embodiments, a machine learning model categorizes magazine styles and present publishing features based on those magazines viewed or subscribed to by a given user.

Abstract: Disclosed herein are methods for treating an Ebola virus and inhibiting the transmission and propagation thereof.

Abstract: A pontoon boat including a thruster system is disclosed. The pontoon boat executes various operations relating to a speed and heading of the pontoon boat.

Abstract: Described herein are devices and methods for pumping blood in a patient in need of circulatory assistance or a replacement heart. Instead of providing a temporary solution for these patients, the devices may be permanently implanted. The devices linearly reciprocate a shuttle within a housing to move blood into and out of the housing, and rotate the shuttle to selectively direct the movement of blood into and out of a plurality of ports in the housing.

Abstract: Method and Systems for configuring, monitoring, updating and validating Internet of Things (IoT) software code and configuration using blockchain smart contract technology. The use of smart contracts for delivering software code and or configuration scripts to IoT devices is an enhanced cybersecurity solution meant to ensure the security and integrity of IoT devices. The use of smart contracts is also shown how it can be used for verifying the integrity of the IoT devices software code and or configuration is a proactive method of cybersecurity. The proactive cybersecurity method will prevent man in the middle attacks as well as preventing rogue devices from impacting other IoT devices or networks.

Abstract: Providing a risk analysis report for an undesired event may include identifying an attack type resulting in the undesired event and at least one requirement for a successful attack. Providing the report may further include obtaining protection data associated with protection measures that affect the requirements for a successful attack, performing each simulation in a plurality of Monte Carlo simulations for the attack type a number N of times based on the undesired event, the attack type, and the protection data, and in response to determining that the N performances of a simulation indicate at least one wildcard, performing it an additional N times. Providing the report may also include identifying a vulnerability of the protection measures to the attack type based on the performances of the plurality of Monte Carlo simulations and generating the risk analysis report for the undesired event based on the attack type and the vulnerability.

Abstract: A drilling system for drilling a wellbore that includes a drill string rotatable in a first direction. The system also includes a bottom hole assembly (BHA) that includes: a drill bit, a housing with a bore, a first fluid-driven motor in fluid communication with the bore and connected with and configured to rotate a portion of the BHA in a second direction opposite the first direction, a second fluid-driven motor in fluid communication with the bore and connected with and configured to rotate the drill bit, a valve in fluid communication with a vent including a flow path arranged to direct fluid away from any one or both of the fluid-driven motors, and a controller in communication with and configured to adjust a drilling parameter of the BHA by controlling the valve to adjust a flow rate of the fluid output from the valve into the vent.

Abstract: A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, an acoustic waveguide, an articulation section, an end effector, and an articulation drive assembly. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The shaft couples the end effector and the body together. The acoustic waveguide is coupled with the transducer. The articulation section includes a collar that is located distal to a nodal portion of the waveguide and is operable to deflect the end effector away from the longitudinal axis. The end effector comprises an ultrasonic blade in acoustic communication with the ultrasonic transducer. The articulation drive assembly is operable to drive articulation of the articulation section. The articulation drive assembly comprises at least one translating articulation driver coupled with the collar. The ultrasonic blade is operable to deliver ultrasonic vibrations to tissue even when the articulation section is in an articulated state.

Abstract: A component includes an additively manufactured component with an internal passage; and an additively manufactured elongated member within the internal passage. A method of additively manufacturing a component including additively manufacturing a component with an internal passage; and additively manufacturing an elongated member within the internal passage concurrent with additively manufacturing the component.

Abstract: Disclosed herein is a web user experience improvement for digital magazines. A digital magazine viewing platform is integrated with a digital magazine publishing platform including features that leverage the integration including user interface arrangement based on viewing habits and ripped content that is insertable into draft digital magazine documents. In some embodiments, a machine learning model categorizes magazine styles and present publishing features based on those magazines viewed or subscribed to by a given user.

Abstract: A surgical apparatus comprises a body, a shaft assembly, and an end effector. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with an ultrasonic transducer via an acoustic waveguide that extends through the shaft assembly. The clamp arm is configured to pivot about a first pivot point toward and away from the ultrasonic blade along a first angular path from a first position to a second position to thereby provide a tissue sealing mode of operation. The clamp arm is further configured to pivot about a second pivot point toward and away from the ultrasonic blade along second angular path from the second position to a third position to thereby provide a tissue cutting and sealing mode of operation. The second pivot point is proximal to the first pivot point.

Abstract: Apparatuses and methods for delivering a fluid, including a viscous fluid. These apparatuses may include a fluid reservoir, two or more piston chambers, a manifold, a delivery port, and a drive assembly and may be configured to inject either a predetermined amount of fluid or a continuous stream of fluid. These apparatuses may also be configured to switch between filling, injection and aspiration modes. These apparatuses may generally be hand-held and lightweight and may provide a significant mechanical advantage to the user.

Abstract: A packaging system includes a container defining an internal volume. The container includes a container body and a lid hingedly connected to the container body. The packaging system further includes a dunnage panel received in the internal volume of the container. The dunnage panel includes a plurality of discontinuous lines of weakness.