Abstract: A mechanism is provided in a data processing system comprising a processor and a memory, the memory comprising instructions that are executed by the processor to specifically configure the processor to implement a question prediction and answering engine for predicting questions a medical professional is attempting to answer. An interaction monitoring component monitors interaction of a medical professional with a patient electronic medical record (EMR). A question selection component selects a set of questions the medical professional is attempting to obtain an answer to from the patient EMR. The question prediction and answering engine analyzes the patient EMR to generate a set of answers to the set of questions from at least a portion of the patient EMR and outputs a report correlating the set of questions and the set of answers to the medical professional.

Abstract: Methods and systems are provided for securing tissue to bone. A suture anchor can include an elongate body having a proximal end and a distal end and an external surface with a plurality of longitudinally spaced bone-engaging features formed at least partially circumferentially thereon over at least a portion of a length of the suture anchor. The proximal end can have a lumen extending at least partially into the elongate body and the distal end can have a suture engaging feature proximate thereto. A first series of bone-engaging features can have a dimension that increases from a distal to a proximal end of each bone-engaging feature of the first series of bone-engaging features. A second series of bone-engaging features can have a dimension that decreases from a distal to a proximal end of each bone-engaging feature of the second series of bone-engaging features.

Abstract: Provided herein are organ preservation solutions and methods of use thereof for preserving organs. In particular, provided herein are preservation solutions comprising a mineralocorticoid receptor antagonist, aldehyde dehydrogenase agonist, and/or histone deacetylase inhibitor, and methods of perfusing and storing an organ while awaiting transplantation or non-transplant surgery.

Abstract: A notation assistant system has a machine learning system, a notation processing system, a scoring system, and a suggestion system. The machine learning system trains a classifier for rating a factor related to a clinical narrative note that describes a patient's health status. The notation processing system processes a clinical narrative note and the scoring system determines a factor rating, such as a completion score or a clarity score. The scoring system provides the factor rating to an end-user device to display to a user. The notation assistant system is configured to perform a method as a user is entering a clinical narrative note to provide real-time feedback, such as the factor rating. The suggestion system is configured to provide suggestions for modifying the clinical narrative note to improve the rating factor. The notation assistant system applies to patient health conditions such as a health status of a patient's heart for a patient receiving care for congestive heart failure.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In one embodiment, a surgical implant is provided having a sheath and an expander that is received within the sheath. Various delivery tools, including a sheath inserter and a driver, are also provided. In use, the sheath inserter can be used to position a tendon within a prepared bone hole, and it can be used to deliver the sheath with a guidewire coupled thereto into the bone hole. The driver can be provided for delivering the expander into the sheath. A loader can optionally be used to load the driver and expander onto the guidewire coupled to the implanted sheath.

Abstract: A system and associated method for assessing level of completeness of healthcare data storage based on collected data. The system includes a collection system, a measurement system, an expectation system, and an alerting system. In a method of assessing the health of stored data, the system collects real-time data from at least one data source, determines measurements for a plurality of parameters based on the collected data, and generates expectations for a future period of time for the plurality of parameters based on data analysis technique. The system also compares the expectations for the future period of time to subsequent measurements collected for that period of time to determine whether the subsequent measurements satisfy an expectation threshold and provide an alert to a client terminal. The alert is a result of the comparison of the expectations and the subsequent measurements and provides an assessment of data storage quality and alerts on anticipated deficiencies.

Abstract: Various systems and methods for streaming an impromptu community are described herein. In one example, a system for streaming impromptu communities includes a data storage device, a community analyzer, and a publisher. In an example, the data storage device can store a number of incoming data sets, wherein each data set identifies a time and location for the origin of the data, a media instance, and an identification of an origin device or origin user. In an example, the community analyzer can operate from the data storage device to use a processor in order to calculate an IC boundary and generate an impromptu community (IC) indicator based on the proximity and temporality of the number of incoming data sets. In an example, the processor can modify the number of data sets to include the IC indicator.

Abstract: The present invention shows that intranasal administration of E1/E3-defective adenovirus particles may confer rapid and broad protection against viral and bacterial pathogens in a variety of disease settings. Protective responses lasted for many weeks in a single-dose regimen in animal models. When a pathogen-derived antigen gene was inserted into the E1/E3-defective adenovirus genome, the antigen-induced protective immunity against the specific pathogen was elicited before the adenovirus-mediated protective response declined away, thus conferring rapid, prolonged, and seamless protection against pathogens. In addition to E1/E3-defective adenovirus, other bioengineered non-replicating vectors encoding pathogen-derived antigens may also be developed into a new generation of rapid and prolonged immunologic-therapeutic (RAPIT).

Abstract: A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose on a first portion of at least a first limb and has a second portion connected to the filament engagement feature of the anchor. Preferably, at least one free filament limb, which in some embodiments is a length of the first filament and in other embodiments is a second filament, is capable of being passed through tissue to be repaired and has at least one end passable through the noose to enable incremental tensioning of the tissue after the anchor is fixated in bone. The noose strangulates the free filament limb when tension is applied to at least one of the free filament limb and the noose.

Abstract: The present invention shows that intranasal administration of E1/E3-defective adenovirus particles may confer rapid and broad protection against viral and bacterial pathogens in a variety of disease settings. Protective responses lasted for many weeks in a single-dose regimen in animal models. When a pathogen-derived antigen gene was inserted into the E1/E3-defective adenovirus genome, the antigen-induced protective immunity against the specific pathogen was elicited before the adenovirus-mediated protective response declined away, thus conferring rapid, prolonged, and seamless protection against pathogens. In addition to E1/E3-defective adenovirus, other bioengineered non-replicating vectors encoding pathogen-derived antigens may also be developed into a new generation of rapid and prolonged immunologic-therapeutic (RAPIT).

Abstract: A method, a system, and a computer program product are provided. Speech signals from a medical conversation between a medical provider and a patient are converted to text based on a first domain model associated with a medical scenario. The first domain model is selected from multiple domain models associated with a workflow of the medical provider. One or more triggers are detected, each of which indicates a respective change in the medical scenario. A corresponding second domain model is applied to the medical conversation to more accurately convert the speech signals to text in response to each of the detected one or more triggers. The corresponding second domain model is associated with a respective change in the medical scenario of the workflow of the medical provider. A clinical note is provided based on the text produced by converting the speech signals.

Abstract: The present invention shows that intranasal administration of E1/E3-defective adenovirus particles may confer rapid and broad protection against viral and bacterial pathogens in a variety of disease settings. Protective responses lasted for many weeks in a single-dose regimen in animal models. When a pathogen-derived antigen gene was inserted into the E1/E3-defective adenovirus genome, the antigen-induced protective immunity against the specific pathogen was elicited before the adenovirus-mediated protective response declined away, thus conferring rapid, prolonged, and seamless protection against pathogens. In addition to E1/E3-defective adenovirus, other bioengineered non-replicating vectors encoding pathogen-derived antigens may also be developed into a new generation of rapid and prolonged immunologic-therapeutic (RAPIT).

Abstract: A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose on a first portion of at least a first limb and has a second portion connected to the filament engagement feature of the anchor. Preferably, at least one free filament limb, which in some embodiments is a length of the first filament and in other embodiments is a second filament, is capable of being passed through tissue to be repaired and has at least one end passable through the noose to enable incremental tensioning of the tissue after the anchor is fixated in bone. The noose strangulates the free filament limb when tension is applied to at least one of the free filament limb and the noose.

Abstract: The present invention shows that intranasal administration of E1/E3-defective adenovirus particles may confer rapid and broad protection against viral and bacterial pathogens in a variety of disease settings. Protective responses lasted for many weeks in a single-dose regimen in animal models. When a pathogen-derived antigen gene was inserted into the E1/E3-defective adenovirus genome, the antigen-induced protective immunity against the specific pathogen was elicited before the adenovirus-mediated protective response declined away, thus conferring rapid, prolonged, and seamless protection against pathogens. In addition to E1/E3-defective adenovirus, other bioengineered non-replicating vectors encoding pathogen-derived antigens may also be developed into a new generation of rapid and prolonged immunologic-therapeutic (RAPIT).

Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.

Abstract: A mechanism is provided in a data processing system comprising a processor and a memory, the memory comprising instructions that are executed by the processor to specifically configure the processor to implement a relevant information graphical presentation engine for providing a graphical user interface (GUI) that presents information from a patient electronic medical record (EMR). The relevant information graphical presentation engine generates a GUI presenting patient EMR data pertinent to a condition of the patient. The relevant information graphical presentation engine identifies a change in treatment recorded in the patient EMR, submits a question to a healthcare cognitive system to query the patient EMR for a reason for the change in treatment, and receives at least one answer from the healthcare cognitive system identifying of a reason portion of the patient EMR that provides a reason for the change in treatment.

Abstract: Provided is a method, a computer program product, and a system for generating personalized treatment options and associated outcome estimates for patients. The method includes retrieving information from an electronic health records database relating to a patient cohort, detecting decision points from the information retrieved, and computing actual treatment options from the decision points. The method also includes computing precision cohort treatment options from the decision points using precision cohort analytics on a patient group and analyzing the decision points by comparing the actual treatment options with the precision cohort treatment options for each of the decision points to determine recommended measures. The method further includes generating a precision population analysis report based on the recommended measure.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In one embodiment, a surgical implant is provided having a sheath and an expander that is received within the sheath. Various delivery tools, including a sheath inserter and a driver, are also provided. In use, the sheath inserter can be used to position a tendon within a prepared bone hole, and it can be used to deliver the sheath with a guidewire coupled thereto into the bone hole. The driver can be provided for delivering the expander into the sheath. A loader can optionally be used to load the driver and expander onto the guidewire coupled to the implanted sheath.

Abstract: A mechanism is provided for presenting contextually relevant patient data in relation to other patients in a graphical user interface. Using a medical condition associated with a patient and a current treatment being followed by the patient, a cohort of similar patients with the same medical condition are identified. For each of the patients in the cohort, a set of next treatments are identified for those patients that stopped the current treatment and followed a next treatment. For each next treatment followed by a patent in the cohort of similar patients, a determination is made as to whether the next treatment controlled or failed to control the same medical condition for the patient. Then a presentation is provided indicating the set of next treatments, a number of patients following each next treatment, whether each treatment controlled or failed to control the same medical condition, and a statistical significance.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In one embodiment, a surgical implant is provided having a sheath and an expander that is received within the sheath. Various delivery tools, including a sheath inserter and a driver, are also provided. In use, the sheath inserter can be used to position a tendon within a prepared bone hole, and it can be used to deliver the sheath with a guidewire coupled thereto into the bone hole. The driver can be provided for delivering the expander into the sheath. A loader can optionally be used to load the driver and expander onto the guidewire coupled to the implanted sheath.