Abstract: Various systems and methods for streaming an impromptu community are described herein. In one example, a system for streaming impromptu communities includes a data storage device, a community analyzer, and a publisher. In an example, the data storage device can store a number of incoming data sets, wherein each data set identifies a time and location for the origin of the data, a media instance, and an identification of an origin device or origin user. In an example, the community analyzer can operate from the data storage device to use a processor in order to calculate an IC boundary and generate an impromptu community (IC) indicator based on the proximity and temporality of the number of incoming data sets. In an example, the processor can modify the number of data sets to include the IC indicator.

Abstract: Participants of a group of participants in a chat may be associated with neighborhoods. A neighborhood associated with a participant includes a subset of the participants and represents the participants whose messages the associated participant can see in the chat. When a participant generates a message, the message is presented to an audience that includes each participant with the participant that generated the message in their associated neighborhood. As the message receives indications of approval (e.g., “likes”), the size of the audience is increased to include additional participants. Once the message receives a threshold number of indications of approval, the message may be displayed to all of the participants in the chat. The size of the neighborhoods may be dynamically adjusted based on the number of messages that are generated in each neighborhood to keep the number of messages that are presented within a predetermined range.

Abstract: The present invention shows that intranasal administration of E1/E3-defective adenovirus particles may confer rapid and broad protection against viral and bacterial pathogens in a variety of disease settings. Protective responses lasted for many weeks in a single-dose regimen in animal models. When a pathogen-derived antigen gene was inserted into the E1/E3-defective adenovirus genome, the antigen-induced protective immunity against the specific pathogen was elicited before the adenovirus-mediated protective response declined away, thus conferring rapid, prolonged, and seamless protection against pathogens. In addition to E1/E3-defective adenovirus, other bioengineered non-replicating vectors encoding pathogen-derived antigens may also be developed into a new generation of rapid and prolonged immunologic-therapeutic (RAPIT).

Abstract: Embodiments described herein relate to enabling a lightweight way of recording and sharing video messages intended to provide input to a future meeting that cannot be personally attended. A person who cannot attend the meeting pre-records their thoughts and remarks for the meeting as video clips for presentation at the meeting. A physical device with at least a display is presented at the meeting. The physically present participants can play the pre-recorded clips on the device. Video of participants' responses to the clips is recorded and made available so that the represented attendee can view the participants' responses.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In particular, various delivery tools, including a variety of sheath inserter tools, are provided. The tools can be used to position a tendon within a prepared bone hole, and to deliver a sheath into the bone hole.

Abstract: A releasable gear strap for retaining and securing articles has a locking head and a strap portion. The locking head has a retaining loop and a tab. The strap portion connects to the locking head and has a tail section. A pivoting locking member extends from the tail section of the strap portion, and includes a release cam surface and an aperture. The retaining loop and the tab are positioned on the locking head such that the release cam surface clears the retaining loop simultaneously with the tab seating in the aperture, when the tail section of the strap portion is urged through the retaining loop. A stabilizer on the locking head under the retaining loop and tab help reduce bending of the locking head.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In one embodiment, a surgical implant is provided having a sheath and an expander that is received within the sheath. Various delivery tools, including a sheath inserter and a driver, are also provided. In use, the sheath inserter can be used to position a tendon within a prepared bone hole, and it can be used to deliver the sheath with a guidewire coupled thereto into the bone hole. The driver can be provided for delivering the expander into the sheath. A loader can optionally be used to load the driver and expander onto the guidewire coupled to the implanted sheath.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In particular, various delivery tools, including a variety of sheath inserter tools, are provided. The tools can be used to position a tendon within a prepared bone hole, and to deliver a sheath into the bone hole.

Abstract: A multielectrode array with a fluidic channel and its method of fabrication are presented here. In accordance with various embodiments, the present invention allows for scalability, reproducibility, and precision dimension control by utilizing a lithography dependent process. In one embodiment, the present invention provides for a microelectrode that is a neural implant, with the microelectrode configured for connection to a fluidic channel. In another embodiment, the fluidic channel may deliver growth factors and/or drugs.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In one embodiment, a surgical implant is provided having a sheath and an expander that is received within the sheath. Various delivery tools, including a sheath inserter and a driver, are also provided. In use, the sheath inserter can be used to position a tendon within a prepared bone hole, and it can be used to deliver the sheath with a guidewire coupled thereto into the bone hole. The driver can be provided for delivering the expander into the sheath. A loader can optionally be used to load the driver and expander onto the guidewire coupled to the implanted sheath.

Abstract: Participants of a group of participants in a chat may be associated with neighborhoods. A neighborhood associated with a participant includes a subset of the participants and represents the participants whose messages the associated participant can see in the chat. When a participant generates a message, the message is presented to an audience that includes each participant with the participant that generated the message in their associated neighborhood. As the message receives indications of approval (e.g., “likes”), the size of the audience is increased to include additional participants. Once the message receives a threshold number of indications of approval, the message may be displayed to all of the participants in the chat. The size of the neighborhoods may be dynamically adjusted based on the number of messages that are generated in each neighborhood to keep the number of messages that are presented within a predetermined range.

Abstract: The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to recombinant human adenovirus vectors for delivery of avian immunogens and antigens, such as avian influenza into avians. The invention also provides methods of introducing and expressing an avian immunogen in avian subjects, including avian embryos, as well as methods of eliciting an immunogenic response in avian subjects to avian immunogens.

Abstract: Mechanisms are provided to implement secure distributed patient consent and patient information management that addresses the competing needs for efficient access to electronic medical records by authorized parties while maintaining protection of privacy of patient health related information and complying with governing regulations. The mechanisms of the illustrative embodiments implement a tamper-proof and immutable ledger storage system to manage patient consent information and distribution of patient information based on the patient consent information. The ledger storage system operates in conjunction with a master patient record index (MPRI) component to enable the exchange of patient information among health providers once consent has been granted by the patient.

Abstract: Mechanisms are provided for executing patient information transactions. The mechanism store, in a ledger storage system, for each patient, a history of patient consents associated with patient transactions in a healthcare network, comprising patient consent data structures associated with the patient information transferred between participants as part of the transaction. The mechanisms store a master patient record index (MPRI) for each of the patients. The MPRI stores record locators identifying locations of portions of patient information for the patient on different computing devices associated with different health providers. The mechanisms execute, by a transaction manager, a transaction to grant access to a portion of a patient's information based on consent information stored in the ledger storage system and record locators in the MPRI. The mechanisms update, by a ledger storage engine of the data processing system, the history of transactions based on the execution of the transaction.

Abstract: A releasable gear strap for retaining and securing articles has a locking head and a strap portion. The locking head has a retaining loop and a tab. The strap portion connects to the locking head and has a tail section. A pivoting locking member extends from the tail section of the strap portion, and includes a release cam surface and an aperture. The retaining loop and the tab are positioned on the locking head such that the release cam surface clears the retaining loop simultaneously with the tab seating in the aperture, when the tail section of the strap portion is urged through the retaining loop. A stabilizer on the locking head under the retaining loop and tab help reduce bending of the locking head.

Abstract: Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

Abstract: The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to recombinant human adenovirus vectors for delivery of avian immunogens and antigens, such as avian influenza into avians. The invention also provides methods of introducing and expressing an avian immunogen in avian subjects, including avian embryos, as well as methods of eliciting an immunogenic response in avian subjects to avian immunogens.

Abstract: Surgical constructs and methods are provided for securing soft tissue to bone. One exemplary embodiment of a construct is formed from a suture filament and includes two terminal ends of filament and an intermediate portion disposed along at least a portion of a length extending between the terminal ends. The construct can have a first terminal end that is the first terminal end of the filament, and a second terminal end that includes a loop. The loop can be formed by disposing the second terminal end of the filament within a volume of a portion of the intermediate portion of the filament. In some disclosed methods, both terminal ends of the filament can be passed through tissue when performing soft tissue repairs. Various other embodiments of constructs and methods are provided, including constructs having two or more filaments associated with an anchor and methods of using such constructs.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In general, various inserter tools are provided for simultaneously delivering an expandable sheath and an expander into bone. With both components of the implant mounted on the same tool, the sheath and a ligament can be advanced into a bone hole and the expander, which trails behind the sheath during delivery of the sheath, can be advanced into the sheath to expand the sheath and anchor the sheath and ligament within the bone hole.