Patents by Inventor C. Wade

C. Wade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4020064
    Abstract: Compounds of the following formula and their pharmaceutically acceptable salts ##STR1## wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: April 26, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4012374
    Abstract: Compounds having the formula ##STR1## wherein A is a straight or branched chain alkylene group; R.sub.1 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, nitro, amino, or cyano; and n is 0, 1, or 2; are useful central nervous system depressants.
    Type: Grant
    Filed: September 29, 1975
    Date of Patent: March 15, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • Patent number: 4007191
    Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from ##STR2## R.sup.3 is selected from phenyl, phenyl-lower alkyl, substituted phenyl, and substituted phenyl-lower alkyl; R.sup.4 is selected from R.sup.3 and a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine; and A is a straight or branched chain alkylene of 2 to 8 carbons are disclosed. These compounds exhibit antidepressant activity.
    Type: Grant
    Filed: October 14, 1975
    Date of Patent: February 8, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 4006238
    Abstract: Method of treating allergies with a pharmaceutical composition containing as the active ingredient a compound or mixture of compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, or cyano; and A is a straight or branched chain alkylene of 1 to 8 carbons.
    Type: Grant
    Filed: August 28, 1975
    Date of Patent: February 1, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter C. Wade
  • Patent number: 4002574
    Abstract: The invention provides aqueous solutions of (1) the reaction product of anhydrous trimethyl borate with titanium tetrachloride and (2) polyvinyl alcohol, preferably not exceeding about 0.5 weight percent of each. These solutions have a pH of about 1, but when ammonium hydroxide is added, the pH may be raised to about 10 without precipitation of titanium or gelation of the polyvinyl alcohol.When the pH of the above solutions is adjusted to between about 2 and about 10, the solutions are photosensitive. When these solutions are in a confined zone, sunlight or actinic radiation in the range between ultraviolet light and the lower wavelengths of the visible spectrum causes oxygen from the air above the solutions to be consumed until it is all gone. Then, reduction of the colorless dissolved Ti(IV) compound to the dark blue Ti(III) state occurs without precipitation of the Ti(III) product or reoxidation to Ti(IV). The blue Ti(III) solution is quickly reoxidized by reexposure to air.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: January 11, 1977
    Assignee: Ventron Corporation
    Inventor: Robert C. Wade
  • Patent number: 3996363
    Abstract: Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, amino, nitro and cyano; R.sup.3 is hydrogen, lower alkyl or lower alkenyl; R.sup.4 is hydrogen, halogen, or lower alkyl; and A is straight or branched chain alkylene are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: December 7, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3996362
    Abstract: Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, trifluoromethyl, or cyano; R.sup.3 is hydrogen or lower alkyl; R.sup.4 and R.sup.5 are selected from hydrogen, halogen, lower alkyl, or lower alkoxy; the dashed line indicates the optional presence of a double bond; and A is straight or branched chain alkylene of 1-8 carbons; are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: May 28, 1975
    Date of Patent: December 7, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3995045
    Abstract: Compounds which are useful as anti-inflammatory agents have the formula ##SPC1##Wherein X, Y, Y' and Z are as defined herein.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: November 30, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • Patent number: 3981881
    Abstract: Compounds having the formula ##SPC1##Wherein A is a straight or branched chain alkylene group; R.sub.1 is hydrogen, halogen, alkyl, alkoxy, alkylthio, nitro, amino, or cyano; and R.sub.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, nitro, amino, or cyano; and n is 1 or 2, with the proviso that when n is 2, R.sub.1 is alkyl, alkoxy, or halogen; are useful central nervous system depressants.
    Type: Grant
    Filed: August 14, 1975
    Date of Patent: September 21, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • Patent number: 3969366
    Abstract: Compounds of the following formula and their pharmaceutically acceptable salts ##SPC1##Wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: July 13, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3969343
    Abstract: Triazolo[4,3-d][1,4]benzodiazepine-3,6-diones having in the 2-position an alkyl, phenyl or arylalkyl substituent are useful anti-inflammatory agents.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: July 13, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • Patent number: 3959286
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; R.sup.3 is phenyl or substituted phenyl; and R is lower alkyl or cycloalkyl of 3 to 7 carbons are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: January 6, 1975
    Date of Patent: May 25, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3947452
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and m is 1 or 2 are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: January 6, 1975
    Date of Patent: March 30, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3946010
    Abstract: Compounds of the structure ##SPC1##Are provided which are useful as anti-inflammatory agents.Compounds having the structure ##SPC2##Wherein R is lower alkyl, phenyl, or benzyl and X is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy or alkylthio, are useful as anti-inflammatory agents.The term "alkyl", as used throughout the specification, either by itself or as part of a larger group, refers to both straight and branched chain alkyl groups containing 1, 2, 3 or 4 carbon atoms.The term "alkoxy", as used throughout the specification, refers to a group of the formula Y--O--, wherein Y is alkyl as defined above.The term "halogen", as used throughout the specification, refers to fluorine, chlorine, bromine, and iodine.Preferred are those compounds wherein R is alkyl and X is hydrogen or halogen; most preferred are those compounds wherein R is methyl and X is 5-Cl.The compounds of formula I are useful in the treatment of inflammatory conditions in mammalian speices, e.g., rats, dogs, cats, monkeys, etc.
    Type: Grant
    Filed: April 9, 1975
    Date of Patent: March 23, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • Patent number: 3943727
    Abstract: A portable electrically refrigerated water cooler is adapted for year-round outdoor use by means of a thermostatically controlled heating cable wrapped about the water-containing components, and a similarly controlled heating element immersed in the water reservoir. A combined faucet-switch unit permits cool water to be pumped through the faucet for immediate use and prevents contaminants from entering the water when the switch is off.
    Type: Grant
    Filed: April 10, 1974
    Date of Patent: March 16, 1976
    Inventor: George C. Wade
  • Patent number: 3940398
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and R is a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are also useful as antiinflammatory agents.
    Type: Grant
    Filed: January 23, 1975
    Date of Patent: February 24, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3940397
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is ##SPC2##Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.
    Type: Grant
    Filed: November 13, 1974
    Date of Patent: February 24, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3935227
    Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is selected from ##SPC2##Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: August 28, 1974
    Date of Patent: January 27, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold Richard Vogt
  • Patent number: 3933676
    Abstract: This invention relates to stabilized aqueous solutions of sodium borohydride containing soluble zinc in the form of sodium zincate. They may contain from about 35 to about 46.9 percent sodium hydroxide and from about 9.35 to about 12.9 percent sodium borohydride and 0.5 to 3 percent zinc which is preferentially added as zinc oxide and reacted with the sodium hydroxide present in the solution to form sodium zincate. These solutions may be used to react with sodium bisulfite to form solutions of sodium hydrosulfite in excellent yield. Such hydrosulfite solutions do not form trace amounts of hydrogen sulfide and do not darken or corrode copper based paper machine wires in contrast to hydrosulfite solutions which contain no soluble zinc.
    Type: Grant
    Filed: April 8, 1974
    Date of Patent: January 20, 1976
    Assignee: Ventron Corporation
    Inventor: Robert C. Wade