Abstract: An apparatus for intraoral imaging has an illumination source that directs light to an object. An imaging apparatus forms an image at an image sensor array from reflected light from the object, the imaging apparatus having an optical stop along an optical axis. A phase modulator is disposed at or near the optical stop. An image processor conditions data from the image sensor array and provides processed image data of the object.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A user interface (UI), data structures and algorithms facilitate programming, analyzing, debugging, embedding, and/or modifying problems that are embedded or to be embedded on an analog processor (e.g., quantum processor), increasing computational efficiency and/or accuracy of problem solutions. The UI provides graph representations (e.g., source graph, target graph and correspondence therebetween) with nodes and edges which may map to hardware components (e.g., qubits, couplers) of the analog processor. Characteristics of solutions are advantageously represented spatially associated (e.g., overlaid or nested) with characteristics of a problem. Characteristics (e.g., bias state) may be represented by color, pattern, values, icons. Issues (e.g., broken chains) may be detected and alerts provided.

Abstract: According to one configuration, a mobile communication device receives first communications over a first wireless communication link from a first wireless network (which potentially supports data only communications). The first communications received over the first wireless network can include a message indicating a pending incoming call available over a second wireless network (which potentially supports voice/call communications). In response to receiving the message indicating the pending incoming call, the mobile communication device is operated to receive second communications (such as a paging signal) from over the second wireless network. For example, the mobile communication device listens for a paging signal from the second wireless network further indicating the pending incoming call. If desired, an operator of the mobile communication device can accept the incoming call via a second wireless communication link to the second wireless network.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: Exemplary method and apparatus embodiments of this application can obtain a digital model of an individual intraoral dentition and perform tooth surface restoration after brace representation removal that includes wires and brackets.

Abstract: Contemplated compositions and methods comprise chimeric molecule complexes that advantageously provide activating signaling to immune competent cells when bound to ALL cells. Furthermore, chimeric molecule complexes include an Fc portion to extend serum half live time and facilitate purification.

Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A method relates generally to comparison of a communications system modelled with a behavioral model and implemented with a circuit realization. In this method, operation of the communications system is simulated with the behavioral model on a computing device to obtain a first pulse response. The simulating includes first equalizing first data with a first equalizer of the behavioral model to obtain the first pulse response. The circuit realization is operated to obtain a second pulse response. The operating includes: second equalizing second data corresponding to the first data with a second equalizer of the circuit realization to obtain the second pulse response. The second pulse response from the circuit realization is loaded to memory of the computing device. The first pulse is loaded to the memory of the computing device. The first pulse response and the second pulse response are compared with one another by the computing device.

Abstract: An exemplary optical apparatus has an OCT imaging apparatus with a first light source for low coherence light of wavelengths above a threshold wavelength and a signal detector that obtains an interference signal between low coherence light from the sample and low coherence light reflected from a reference. A surface contour imaging apparatus has a second light source that emits one or more wavelengths of surface illumination below the threshold wavelength, a camera to acquire images from illumination reflected from the sample. The exemplary optical apparatus and/or exemplary methods for using the same can provide reduced errors in generating a dental 3D surface mesh.

Abstract: The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.

Abstract: An electronic assembly, comprising a carrier wafer having a top wafer surface and a bottom wafer surface; an electronic integrated circuit being formed in the carrier wafer and comprising a wafer contact pad on the top wafer surface; said carrier wafer comprising a through-wafer cavity joining the top and bottom wafer surfaces; a component chip having a component chip top surface, a component chip bottom surface and component chip side surfaces, the component chip being held in said through-wafer cavity by direct contact of at least a side surface of said first component chip with an attachment metal that fills at least a portion of said through-wafer cavity; said component chip comprising at least one component contact pad on said component chip top surface; a first conductor connecting said wafer contact pad and said component contact pad.

Abstract: Disclosed herein are nucleic acids comprising multifunctional double-stranded break reporter constructs for stable or transient transfection into a cell, as well as detecting a type of double-stranded break repair mechanism in a cell. Also provided are methods for detecting types of double-stranded break repair mechanism in a cell, as well as vectors and cells comprising nucleic acids comprising multifunctional double-stranded break reporter constructs.

Abstract: System utilization related to memory usage can be monitored by storing host memory usage information in the corresponding host physical memory. However, retrieving this information can be a high overhead operation because it involves engaging with the operating system of each host. Moreover, storing memory usage information in the host physical memories can pose a security risk if they also store privileged data. Network interfaces according to the present disclosure provide unobtrusive and secure support for monitoring of network and other system resources such as regions of memory within host physical memories. Implementations according to the present disclosure include a plurality of memory region counters stored on a network interface. Each memory region counter corresponds to one of the memory regions located in a physical memory of a host coupled to the network interface. Each of the counters includes a system utilization metric associated with its corresponding memory region.

Abstract: A method for imaging a tooth surface, the method executed at least in part on a computer, directs an excitation signal toward the tooth from a scan head and obtains a depth-resolved response signal emanating from the tooth, wherein the response signal encodes tooth surface structure information. Liquid and tooth surfaces are segmented from the depth-resolved response signal. The tooth surface structure information is adjusted based on the segmented liquid. A 3D image of the tooth is reconstructed according to the depth-resolved response signal and the adjusted tooth surface structure information. The 3D image content is displayed, stored, or transmitted.

Abstract: Chimeric proteins comprising an N-terminal domain derived from an N-terminal nucleotide binding domain of TDP-43 and a C-terminal domain derived from a splicing repressor are described. These proteins may be administered to a subject to treat or prevent disease manifesting TDP-43 proteinopathy such as inclusion body myocytosis, amyotrophic lateral sclerosis (ALS), or frontotemporal dementia (FTD).

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: A testing device is provided. The testing device includes a capturing tool and a microfluidic chip having a plurality of chambers connected in a network, a sample receiving port connected to the network, and a guide structure configured to receive the capturing tool, wherein the capturing tool is configured to capture sample in a distal position from the guide structure and further configured to transfer the captured sample to the sample receiving port in a proximal position from the guide structure.