Abstract: A millimeter-wave communication system includes a transmitter and a receiver. The transmitter is configured to be connected to a waveguide that is transmissive at millimeter-wave frequencies, the waveguide having a propagation parameter that varies with frequency at the millimeter-wave frequencies. The transmitter is configured to generate a millimeter-wave signal comprising multiple sub-carriers that are modulated with data, wherein each sub-carrier is modulated with a respective portion of the data and is subjected to only a respective fraction of a variation in the propagation parameter, and to transmit the millimeter-wave signal into a first end of the waveguide. The receiver is configured to receive the millimeter-wave signal from a second end of the waveguide, and to extract the data from the multiple sub-carriers.

Abstract: An aircraft comprises a machine body. The machine body encloses a turbofan gas turbine engine and a plurality of ancillary systems. The turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, a combustor module, and an exhaust module. The machine body comprises either one or two fluid inlet apertures. The or each fluid inlet aperture is configured to allow a fluid flow to enter the machine body and to pass through the heat exchanger module. The heat exchanger module is configured to transfer a waste heat load from the gas turbine engine and the ancillary systems to the fluid flow prior to an entry of the fluid flow into the fan module, and thence into the compressor module, the turbine module, the combustor module, and the exhaust module.

Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.

Abstract: Various embodiments relate to a cancellation circuit configured to generate a cancellation signal, including: an attenuator configured to attenuate a transmitted signal from an aggressor transmitter based upon a first attenuation value; an I/Q demodulator configured to split an attenuated signal into in-phase (I) and quadrature signals (Q); a phase interpolator configured to apply a calibration phase shift and a calibration attenuation to the I signal and Q signal and to recombine the I and Q signals; an auxiliary balun coupled to an output of the phase interpolator; and an auxiliary power amplifier with an input connected to the auxiliary balun configured to generate the cancellation signal, wherein the output of the auxiliary power amplifier is connected to an output of a victim transmitter.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: A method of fabricating a gate with a mini field plate includes forming a dielectric passivation layer over an epitaxy layer on a substrate, coating the dielectric passivation layer with a first resist layer, etching the first resist layer and the dielectric passivation layer to form a first opening in the dielectric passivation layer, removing the first resist layer; and forming a tri-layer gate having a gate foot in the first opening, the gate foot having a first width, a gate neck extending from the gate foot and extending for a length over the dielectric passivation layer on both sides of the first opening, the gate neck having a second width wider than the first width of the gate foot, and a gate head extending from the gate neck, the gate head having a third width wider than the second width of the gate neck.

Abstract: In one aspect, the present disclosure provides methods of inhibiting STAT3 in a cell comprising contacting the cell with a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure provides methods of using of the compounds disclosed herein for the treatment of cancer.

Abstract: User equipment receives first connection priority information. In accordance with the first connection priority information, the mobile communication device establishes a first wireless communication link between the user equipment and a first wireless network to communicate first communications. A controller/management resource provides notification of second connection priority information to be used instead of the first connection priority information. In response to detecting a trigger event in which the user equipment is operated to communicate second communications, the user equipment uses the second connection priority information as a replacement to the first connection priority information to establish a second wireless communication link connecting the user equipment to the second network instead of the first network.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: A method for registering an imaging detector to a surface projects and records a sequence having a first sparse pattern of lines followed by a second sparse pattern of lines. A first subset of positions receives lines from both first and second sparse patterns corresponding to a first label. A second subset of positions receives only lines from the first sparse pattern corresponding to a second label. A third subset of positions receives only lines from the second sparse pattern corresponding to a third label. The first, second, and third labels are decoded and each member element of the first, second, and third subsets of positions registered to the imaging detector according to the decoded labels. One or more dense patterns of lines positionally correlated with registered member elements of the decoded labels are projected and recorded. An image of the surface contour is formed according to the recorded pattern.

Abstract: A dental optical coherence tomography system for scanning a sample has a swept source laser configured to generate output light having a range of wavelengths. Two or more optical channels each provide a reference and sample path for the output light, wherein each optical channel has a corresponding detector to provide an output signal according to combined light from the sample and reference, wherein the detector output signal characterizes back-reflected or back-scattered light from the sample path over a range of depths below a surface. A scanning reflector simultaneously directs sample path output light from each of the two or more channels toward the sample surface and directs returned light from the sample to the corresponding sample path and detector. A processor is in signal communication with the detector for each optical channel and that is configured to record and store results from the output signals received from each detector.

Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: A communication management resource receives notification of a request from user equipment to establish a wireless communication link with a remote communication device through a first private wireless network. The communication management resource resides in a second private wireless network to which the user of the user equipment is a member. The request requests use of services provided by the second private wireless network to connect the user equipment to a remote communication device. In response to receiving the request, the second private wireless network retrieves a unique network identifier value assigned to the first private network. Via the unique network identifier value, the communication management resource detects that the first private wireless network is associated with the second wireless network. Based on the association, the communication management resource support communications between the user equipment and the remote communication device.

Abstract: A turbofan gas turbine engine includes heat exchanger module, fan assembly, compressor, turbine and exhaust modules. The fan includes a plurality of fan blades. The heat exchanger in fluid communicates with the fan assembly by an inlet duct, and the heat exchanger includes a plurality of radially-extending hollow vanes arranged in a circumferential array, with a channel extending axially between each pair of adjacent hollow vanes. An airflow entering the heat exchanger is divided between a set of vane airflows and a set of channel airflows. Each vane airflow has a vane mass flow rate FlowVane, and each channel air flow has a channel mass flow rate FlowChan. Each hollow vane includes, an inlet, heat transfer, and exhaust portions, with the inlet portion comprising a diffuser element and the heat transfer portion including at least one heat transfer element. The diffuser element causes FlowVane to be lower than FlowChan.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter (D). The heat exchanger module comprises a plurality of heat transfer elements. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct. The inlet duct has a fluid path length along a central axis of the inlet duct between a downstream-most face of the heat transfer elements and an upstream-most face of the fan assembly. The fluid path length is less than 10.0*D.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly includes a plurality of fan blades defining a fan diameter, and the heat exchanger module is in fluid communication with the fan assembly by an inlet duct. The heat exchanger module includes a plurality of heat transfer elements for transfer of heat from a first fluid contained within the heat transfer elements to an airflow passing over a surface of the heat transfer elements prior to entry of the airflow into an inlet to the fan assembly. At full-power condition, the engine produces a maximum thrust T (N), the heat exchanger module transfers a maximum heat rejection H (W) from the first fluid to the airflow, and a Heat Exchanger Performance parameter PEX (W/N) defined as PEX=H/T is 0.4 to 6.0.

Abstract: An aircraft comprises a machine body which encloses a turbofan gas turbine engine. The turbofan gas turbine engine includes a heat exchanger module, fan assembly, compressor module, turbine module, and exhaust module. The heat exchanger module communicates with the fan assembly by an inlet duct. The heat exchanger module includes first heat transfer elements that transfer heat energy from a first fluid within the transfer elements to an airflow passing over a surface of the transfer elements before entry of the airflow into a fan assembly inlet. The first fluid contained within transfer elements has a temperature, and the airflow passing over the transfer element surface has a temperature. The turbofan gas turbine engine further includes at least one second heat transfer element, with the or each second heat transfer element transfers heat energy from the first fluid to a second fluid.