Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: An SRAM cell with dynamic split ground (GND) and split wordline (WL) for extreme scaling is disclosed. The memory cell includes a first access transistor enabled by a first wordline to control access to cross coupled inverters by a first bitline. The memory cell further includes a second access transistor enabled by a second wordline to control access to the cross coupled inverters by a second bitline. The memory cell further includes a split ground line comprising a first ground line (GNDL) separated from a second ground line (GNDR). The GNDL is connected to a transistor of a first inverter of the cross coupled inverters and the GNDR is connected to a first transistor of a second inverter of the cross coupled inverters.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: According to one configuration, a shared wireless access node supports wireless access for multiple wireless network service providers. A mobile communication device receives notification of multiple wireless network service providers, each of which provides access to a remote network through the shared wireless access node. The notification includes connection information such as priority information assigned to the wireless network service providers. The priority information indicates an order in which to select amongst the multiple available wireless network service providers to access the remote network. Based at least in part on the priority information, the mobile communication device selects a wireless network service provider amongst the multiple wireless network service providers.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: The present techniques are directed to systems and a method for reducing trenching around piles. An exemplary method includes attaching a mooring line to one end of a padeye extender bar that is coupled by another end to a padeye on the pile. The pile is installed in a sediment layer. The padeye extender bar is deployed to hold an attachment point for the mooring line above the sedimenlt layer.

Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.

Abstract: An intraoral scanning apparatus has a source of low coherence light. An interferometer directs the low coherence light to a reference path and a sample path and generates image data according to interference from combined light returned along the reference and sample paths. A fixture is optically coupled to the sample path and has a bite portion featured for clamping between the jaws of a patient, a track that defines a curved scan path for scanning, one or more scanners configured to direct the sample path light to and from the teeth, and an actuator and translation apparatus that urges the one or more scanners along the curved scan path. A control logic processor synchronizes light scanning and acquisition from the fixture. A display is in signal communication with the control logic processor for display of acquired scan data.

Abstract: A method to detect and mitigate sensor or actuator degradation in an automobile system includes: collecting a signal data output from at least one device which is outputting the signal data in response to monitored operational parameters of a motor vehicle system; analyzing patterns of the signal data compared to a signal data output from a nominal operating one of the at least one device using an artificial intelligence program; and identifying when the patterns of the signal data exceed a threshold level indicating the at least one sensor or actuator is operating in a degraded condition.

Abstract: Computer-implemented systems and methods are provided for improved generation and control of conversations. A computing device is utilized to control or simulate conversation using estimated contextual cues extracted from profile information or prior responses. The computing device is configured to automatically tailor a flow of a conversation to an effort to improve relevancy and engagement without the need of a human operator to manually tailor the conversation, which, for example, could be impractically expensive. A structured workflow is maintained in the form of a series of conversation decisions, and a machine learning engine is utilized to maintain a continuously trained data structure that generates predictions that bias conversation decisions (e.g., by weighting tree options) for tailoring the conversation flow.

Abstract: A waveguide includes a core and an electrically-conductive transmission line. The core includes an electrically-insulating material that is transmissive at millimeter-wave frequencies. The core is configured to receive a millimeter-wave signal at a first end of the waveguide, and to guide the millimeter-wave signal to a second end of the waveguide. The electrically-conductive transmission line is coupled in propinquity to the core and is configured to conduct an electrical signal between the first end of the waveguide and the second end of the waveguide, in parallel with the millimeter-wave signal guided in the core.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The invention features soluble fusion protein complexes comprising at least two soluble fusion proteins. For example, the first fusion protein is an anti-CD3 antibody covalently linked to an interleukin-15 (IL-15) polypeptide or functional fragment thereof. The second fusion protein comprises a binding domain that recognizes disease antigens, wherein this domain is covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. One or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof, and the IL-15 domain of first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

Abstract: A self-aligned GaN FinFET device and a method of fabricating the same are disclosed. This self-aligned process helps to fabricate GaN FinFET devices in a scalable manner. This work transforms the T-gate process to incorporate fins to further improve pinch-off and decrease leakage currents on highly scaled GaN HEMT structures. The GaN FinFET structure will also allow for integration of normally-off devices with normally-on devices by varying the fin width. The FinFET improvement combines the fin structure consisting of various fin pitches and widths, gate dielectric, self-aligned gate design, ultra-low ohmic contacts, and vertically scaled epitaxy into a single scalable process.

Abstract: Techniques are disclosed relating to a massive MIMO base station architecture. In some embodiments, a base station is configured to combine signals received by multiple antennas and, for at least a subset of processing elements included in the base station, each processing element is configured to operate on a different portion of the combined signals. In these embodiments, each portion includes signals from multiple antennas. In some embodiments, the portions are different time and/or frequency portions of the combined signals. In some embodiments, this distributed processing may allow the number of antennas of the base station to scale dramatically, provide dynamic re-configurability, facilitate real-time reciprocity-based precoding, etc.

Abstract: The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQQL).

Abstract: Systems and methods for reducing scouring around piles are described. The system includes a pile and an enclosure. The pile has a maximum cross-sectional dimension, Dp. The enclosure is circumferentially disposed around the pile, the enclosure having a first end proximate a surface of a seabed; a second end distal the surface of the seabed; and a maximum cross-sectional dimension, De, wherein De is at least 1.25*Dp.

Abstract: A method for registering an imaging detector to a surface projects and records a sequence having a first sparse pattern of lines followed by a second sparse pattern of lines. A first subset of positions receives lines from both first and second sparse patterns corresponding to a first label. A second subset of positions receives only lines from the first sparse pattern corresponding to a second label. A third subset of positions receives only lines from the second sparse pattern corresponding to a third label. The first, second, and third labels are decoded and each member element of the first, second, and third subsets of positions registered to the imaging detector according to the decoded labels. One or more dense patterns of lines positionally correlated with registered member elements of the decoded labels are projected and recorded. An image of the surface contour is formed according to the recorded pattern.

Abstract: According to one configuration, a shared wireless access node supports wireless access for multiple wireless network service providers. A mobile communication device receives notification of multiple wireless network service providers, each of which provides access to a remote network through the shared wireless access node. The notification includes connection information such as priority information assigned to the wireless network service providers. The priority information indicates an order in which to select amongst the multiple available wireless network service providers to access the remote network. Based at least in part on the priority information, the mobile communication device selects a wireless network service provider amongst the multiple wireless network service providers.

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.