Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, and an exhaust module. The fan assembly includes fan blades defining a fan diameter. The heat exchanger module is in communication with the fan assembly by an inlet duct, and the heat exchanger module further includes radially-extending hollow vanes arranged in a circumferential array, with a channel extending axially between hollow vanes. Each hollow vane accommodates at least one heat transfer element to transfer heat from a first fluid contained within the or each heat transfer element to a corresponding vane airflow passing through the hollow vane and over a surface of the or each heat transfer element. Each hollow vane further includes a flow modulator configured to regulate airflow in proportion to total airflow entering the heat exchanger module in response to a user requirement.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly includes fan blades defining a corresponding fan area (AFAN). The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, and includes radially-extending vanes arranged in a circumferential array with at least one vane including a heat transfer element for heat transfer from a first fluid contained within each element to an airflow passing over a surface of each heat transfer element before entering the fan assembly inlet. Each heat transfer element extends axially along the corresponding vane, with a swept heat transfer element area (AHTE) being the wetted surface area of all heat transfer elements in contact with the airflow. A Fan to Element Area parameter FEA of AHTE/AFAN lies in the range of 47 to 132.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, and an exhaust module. The fan assembly includes a plurality of fan blades defining a fan diameter. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, and the heat exchanger module including a plurality of heat transfer elements for transfer of heat from a first fluid contained within the heat transfer elements to an airflow passing over a surface of the heat transfer elements prior to entry of the airflow into an inlet to the fan assembly. Each heat transfer element may be individually and independently fluidly isolated from the remaining heat transfer elements.

Abstract: A shade matching method for a tooth obtains a plurality of digitized tooth shade references, obtains a three-dimensional (3D) surface representation of a tooth and associated color information defined on the three-dimensional (3D) surface, selects a region on the three-dimensional (3D) surface representation of the tooth, determines a plurality of correspondences with the common tooth shape of all the tooth shade references, computes color difference with each of the tooth shade reference from the plurality of tooth shade references, and records the label corresponding to the shade reference with a smallest difference.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, an inlet duct, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter D, and the heat exchanger module comprises a plurality of heat transfer elements for transfer of heat from a first fluid contained within the heat transfer elements to an airflow passing over a surface of the heat transfer elements prior to entry of the airflow into the fan assembly. In use, the first fluid has a maximum temperature of 80° C., and the heat exchanger module transfers at least 300 kW of heat energy from the first fluid to the airflow.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, and an exhaust module. The fan assembly includes a plurality of fan blades defining a fan diameter (D). The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, and the heat exchanger module includes a plurality of radially-extending hollow vanes arranged in a circumferential array with a channel extending axially between each pair of adjacent hollow vanes. An airflow entering the heat exchanger module is divided between a set of vane airflows through each of the hollow vanes and a set of channel airflows through each of the channels.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter (D), and the heat exchanger module comprises a plurality of heat exchanger elements. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, with the heat exchanger module having an axial length along a central axis between an upstream-most face of the heat exchanger elements and a downstream-most face of the heat exchanger elements. The axial length is in the range of 0.1*D to 5.0*D.

Abstract: An aircraft comprises a machine body. The machine body encloses a turbofan gas turbine engine and a plurality of ancillary systems. The turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a combustor module, a turbine module, and an exhaust module. The machine body comprises a single fluid inlet aperture, with the fluid inlet aperture being configured to allow a fluid cooling flow to enter the machine body and to pass through the heat exchanger module. The heat exchanger module is configured to transfer a waste heat load from the gas turbine engine and the ancillary systems to the fluid cooling flow prior to an entry of the entire fluid cooling flow into the fan module.

Abstract: A method of fabricating a gate with a mini field plate includes forming a dielectric passivation layer over an epitaxy layer on a substrate, coating the dielectric passivation layer with a first resist layer, etching the first resist layer and the dielectric passivation layer to form a first opening in the dielectric passivation layer, removing the first resist layer, and forming a tri-layer gate having a gate foot in the first opening, a gate neck extending from the gate foot, and a gate head extending from the gate neck. The gate foot has a first width, and the gate neck has a second width that is wider than the first width. The gate neck extends for a length over the dielectric passivation layer on both sides of the first opening. The gate head has a third width wider than the second width of the gate neck.

Abstract: A network includes a first candidate pool of multiple upper-layer communication processing units and a second candidate pool of lower-layer communication processing units to support the split-layer processing. Initially, a first upper-layer processing unit and a first lower-layer processing unit in the network provide a first service over a wireless communication link established between a wireless access point and a communication device in a network. In response to receiving a request to support a second service, the network notifies the first upper-layer processing unit of the second service. If a combination of the first upper-layer processing unit and the first lower-layer processing unit cannot support the second service, the first upper-layer processing unit selects a second upper-layer processing unit. The selected second upper-layer processing unit selected from the first candidate pool is used in conjunction with the first lower-layer processing unit to support the second service.

Abstract: A power amplification system includes a Power Amplifier (PA) for amplifying an input RF signal. An adaptive bias circuit is configured to adaptively set a bias of the PA. The adaptive biasing circuit includes a gain expansion circuit, a gain compression circuit and a biasing circuit. The gain expansion circuit derives a gain-expansion control signal from the input RF signal. For a first sub-range of the input RF signal, the gain-expansion control signal has a larger dynamic range than the input RF signal. The gain compression circuit derives a gain-compression control signal from the input RF signal. For a second sub-range of the input RF signal having higher power levels than the first sub-range, the gain-compression control signal has a smaller dynamic range than the input RF signal. The biasing circuit sets the bias of the PA responsively to the gain-expansion control signal and the gain-compression control signal.

Abstract: Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-? receptor.

Abstract: The present disclosure describes a Cone Beam Computed Tomography (CBCT) imaging system and methods of operating the system to minimize the degradation of projection images by metal in a scanned object. The methods determine the location of metal in the scanned object by making an initial low dose scan and then, using information obtained from the low dose scan, perform a second scan that may be used to create a reconstruction with reduced artifacts. The methods also calculate X-ray source and detector scan trajectories which minimize reconstruction artifacts and optimize image quality, especially when a region-of-interest is near metal in the scanned object. Additionally, the methods of the present invention calculate X-ray source and detector scan trajectories that maximize the angular range of X-rays which pass through the region-of-interest that are not blocked by metal in the scanned object.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A communication management resource receives notification of a registration request associated with user equipment present in a wireless network environment. In response to receiving the registration request, the communication management resource executes a roaming management function on behalf of the user equipment. Via the roaming management function, the communication management resource manages roaming of the user equipment in the wireless network environment. Using an SoR type mechanism as described herein allows a PLMN/SNPN operator to control their subscribers to what roaming SNPN network that they should select/reselect during wireless registration and at any time after registration based on the type of wireless services.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: Apparatus and method configured to determine locations of man-made objects within synthetic aperture radar (SAR) imagery. The apparatus and method prescreen SAR imagery to identify potential locations of man-made objects within SAR imagery. The potential locations are processed using a change detector to remove locations of natural objects to produce a target image containing location of substantially only man-made objects.