Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, A, and B are as defined herein. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

Abstract: The disclosure relates to synthetic linings for the gastrointestinal (GI) tract, “Gastrointestinal Synthetic Epithelial Linings” or “GSELs,” which can modulate absorption of drugs, nutrients, and other substances in the GI tract, and one or more permeation enhancers to aid in such absorption. A GSEL is a temporary lining on the inner surface of the lumen of the GI tract, keeping its active agent (e.g., drug, nutrients, or other substances) in intimate contact with the GI mucosa such that the active agent can be absorbed over long periods of time.

Abstract: Compounds of the formula I: or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

Abstract: Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

Abstract: Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: An orchestration controller in a storage solution may establish namespaces, assign each namespace to a host, and establish software-defined storage controllers to handle input-output operations between the hosts and the namespaces. Each namespace is assigned to a given host and the input-output operations to and from the namespace are handled by a specific primary software-defined storage controller. In response to failure of the software defined controller, a secondary software-defined storage controller will take over handling of the input-output operations to and from the namespace. Also, in response to the failure of the software-defined storage controller, the host will direct subsequent input-output operations destined for the namespace to the secondary software-defined storage controller.

Abstract: Local terrain feature location data is obtained from a local sensor device at a user location without a prior-known global position. The local terrain feature location data characterizes relative distances and directions to a plurality of local terrain features nearest to the user location. Global terrain feature location data stored in at least one hardware memory device is accessed. The global terrain feature location data characterizes relative distances and directions between a plurality of distinctive terrain features located in a defined terrain region in terms of absolute global location coordinates. The local terrain feature location data is compared to the global terrain feature location data to develop multiple pattern matching hypotheses, wherein each pattern matching hypothesis characterizes a likelihood of a subset of the local terrain features matching a subset the global terrain features. Global location coordinates for the user location is then determined from the pattern matching hypotheses.

Abstract: The present invention provides moldable, fully scalable cellulose silica-based hydrogels for use as low-cost and safe carriers and aqueous viscosity modifiers in various industrial and medical applications.

Abstract: The disclosure provides basemats for fibrous panels, including a mineral wool present in an amount of at least about 60 wt %, based on the total weight of the basemat, a mineral filler, a cellulose present in an amount of about 1 wt % to about 3 wt %, based on the total weight of the basemat, and a binder. The basemat has a backing side and a facing side. Also provided are fibrous panels including the basemat of the disclosure and a porous veil.

Abstract: The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R3, and R4, are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Abstract: Compositions and methods for treating or reducing symptoms of acute respiratory distress syndrome (ARDS) generally and COVID-19 infection in particular are provided herein. An exemplary method includes administering to the subject an effective amount of cannabichromene to reduce acute respiratory distress syndrome caused by ARDS generally and COVID-19 infection in particular.

Abstract: An orchestration controller in a storage solution may establish namespaces, assign each namespace to a host, and establish software-defined storage controllers to handle input-output operations between the hosts and the namespaces. Each namespace is assigned to a given host and the input-output operations to and from the namespace are handled by a specific primary software-defined storage controller. In response to failure of the software defined controller, a secondary software-defined storage controller will take over handling of the input-output operations to and from the namespace. Also, in response to the failure of the software-defined storage controller, the host will direct subsequent input-output operations destined for the namespace to the secondary software-defined storage controller.

Abstract: Among others, the present invention provides apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material.

Abstract: Among others, the present invention provides apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material.

Abstract: The invention relates to apparatus and methods for apparatus for simultaneously detecting presence or monitoring progression of two or more types of cancer in a biological subject, comprising: a channel or chamber in which the biological subject passes through; and at least one detector placed partially or completely alongside one or more side walls of the channel or chamber, wherein the at least one detector is configured to detect at least one bio-physical or physical property of the biological subject. The invention also relates to apparatus and methods for apparatus for treating the detected diseases or cancers.

Abstract: The invention relates to apparatus and methods for detecting presence or monitoring progression of a disease, particularly a pulmonary disease, comprising: a channel or chamber in which the biological subject passes through; and at least one detector placed partially or completely alongside one or more side walls of the channel or chamber, wherein the at least one detector is configured to detect at least one bio-physical or physical property of the biological subject, and the detected bio-physical or physical property is collected for analysis to determine whether the disease is likely to be present with the biological subject or to determine the status of the disease, thereby providing the ability to determine or monitor progression of the disease. The disease may include a pulmonary or lung disease.

Abstract: Among others, the present invention provides masks each with mask filter or mask body comprising one or more filter layers fabricated by integrated circuit fabrication processes. Such filter layer includes well-defined and substantially uniform pore size, and allows the mask to be washable and reusable. The prevention invention also provides methods for fabricating a single layer or multi-layer mask body or mask filter to be incorporated by a face mask.

Abstract: The invention relates to apparatus for detecting a disease in a biological subject, which comprises a delivery system and at least two sub-equipment units which are combined or integrated in the apparatus, wherein the delivery system is capable of delivering the biological subject to at least one of the sub-equipment units and each sub-equipment unit is capable of detecting at least one property of the biological subject. Also related to the invention are methods for detecting a disease with the apparatus.

Abstract: Among others, the present invention provides apparatus for interacting with a biological subject to detect circulating tumor cells therein, comprising one device for sending a signal to the biological subject and optionally receiving a response to the signal from the biological entity.