Patents by Inventor Carmen Almansa Rosales

Carmen Almansa Rosales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20240059690
    Abstract: The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 20, 2021
    Publication date: February 22, 2024
    Inventors: Ariadna FERNANDEZ-DONIS, José-Luis DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Mónica GARCIA-LOPEZ, Joan-Carles FERNANDEZ-COLLADO, Jordi GONZALEZ-GARCIA, Maria GARRIDO-MARTINEZ
  • Alkylaminoproline derivatives as alpha-2-delta-1 blockers
    Patent number: 11905243
    Abstract: The present invention relates to compounds showing pharmacological activity towards the subunit ?2?#of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels. More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: February 20, 2024
    Assignee: ACONDICIONAMIENTO TARRASENSE
    Inventors: Anita Wegert, Carmen Almansa-Rosales
  • Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Patent number: 11649248
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: May 16, 2023
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
  • Alkylaminoproline Derivatives as alpha-2-delta-1 Blockers
    Publication number: 20230100599
    Abstract: The present invention relates to compounds showing pharmacological activity towards the subunit ?2? # of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels. More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.
    Type: Application
    Filed: October 28, 2022
    Publication date: March 30, 2023
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Anita WEGERT, Carmen ALMANSA-ROSALES
  • HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20220380345
    Abstract: The present invention relates to homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 5, 2020
    Publication date: December 1, 2022
    Inventors: Carmen ALMANSA-ROSALES, Ariadna FERNANDEZ-DONIS, José-Luís DÍAZ-FERNÁNDEZ, Monica GARCIA-LOPEZ, Sergi RODRIGUEZ-ESCRICH, Ute CHRISTMANN
  • Alcoxyamino derivatives for treating pain and pain related conditions
    Patent number: 11401270
    Abstract: The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 2, 2022
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • Salts of (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
    Patent number: 11236110
    Abstract: The present invention relates to (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one salts, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor and/or ?-opioid receptor associated disease.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: February 1, 2022
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Nicolas Tesson
  • PIPERAZINYL AND PIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20220002314
    Abstract: The present invention relates to piperazinyl and piperidinyl quinazolin-4(3H)-one derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 31, 2019
    Publication date: January 6, 2022
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Ariadna FERNÁNDEZ-DONIS, Jose Luís DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Adriana LORENTE-CRIVILLÉ
  • NEW ALKOXYAMINOPYRIDINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20210395249
    Abstract: The present invention relates to new compounds of formula (I) that show dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: November 4, 2019
    Publication date: December 23, 2021
    Inventors: Carmen ALMANSA-ROSALES, Félix CUEVAG-CORDOBÉS
  • NEW TETRAHYDROPYRIMIDODIAZEPIN AND TETRAHYDROPYRIDODIAZEPIN COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20210395254
    Abstract: The present invention relates to new compounds of general formula (I) that show dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels, and noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions composing them, and to their use as medicaments.
    Type: Application
    Filed: November 4, 2019
    Publication date: December 23, 2021
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES
  • Propanamine derivatives for treating pain and pain related conditions
    Patent number: 11111220
    Abstract: The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: September 7, 2021
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION
    Publication number: 20210115062
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazespiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 22, 2021
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • Quinoline and isoquinoline derivatives for treating pain and pain related conditions
    Patent number: 10941138
    Abstract: The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: March 9, 2021
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Susana Yenes-Mínguez, Marina Virgili-Bernado, Monica Alonso-Xalma
  • Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Patent number: 10927128
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: February 23, 2021
    Assignee: ESTEVE PHARMACEUTICALS. S.A.
    Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
  • PROPANAMINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200377464
    Abstract: The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: October 16, 2018
    Publication date: December 3, 2020
    Inventors: Carmen ALMANSA-ROSALES, Félix CUEVAS-CORDOBÉS
  • ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200339597
    Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 18, 2020
    Publication date: October 29, 2020
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • SALTS OF (R)-9-(2,5-DIFLUOROPHENETHYL)-4-ETHYL-2-METHYL-1-OXA-4,9-DIAZASPIRO[5.5]UNDECAN-3-ONE
    Publication number: 20200331929
    Abstract: The present invention relates to (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one salts, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor and/or ?-opioid receptor associated disease.
    Type: Application
    Filed: October 16, 2018
    Publication date: October 22, 2020
    Inventors: Carmen ALMANSA-ROSALES, Nicolas TESSON
  • Tetrahydropyran and thiopyran derivatives having multimodal activity against pain
    Patent number: 10807970
    Abstract: The present invention relates to tetrahydropyran and thiopyran derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 20, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales, Ana Virginia Llorente-Fernandez, Ute Christmann, Sergio Rodriguez Escrich
  • NEW ALCOXYAMINO DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200299297
    Abstract: The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: October 26, 2018
    Publication date: September 24, 2020
    Inventors: Carmen ALMANSA-ROSALES, Félix CUEVAS-CORDOBES
  • NEW ALKOXYAMINO COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200270237
    Abstract: The present invention relates to new compounds of general formula (I) showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the ?-opioid receptor (MOR or mu-opioid receptor). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: October 19, 2018
    Publication date: August 27, 2020
    Inventors: Carmen ALMANSA-ROSALES, Félix CUEVAS-CORDOBES