Patents by Inventor Carmen Almansa Rosales

Carmen Almansa Rosales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10065971
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. wherein Y is n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, —C(O)O—, —C(O)NR8—, —C(O)—, —O— or —C(R4R4?)—; R1 is C(O)R5 or S(O)2R5.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 4, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Ramón Merce-Vidal
  • AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20180237415
    Abstract: The present invention relates to amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 23, 2018
    Inventors: Monica GARCIA-LOPEZ, Carmen ALMANSA-ROSALES
  • SPIRO-ISOQUINOLINE-4,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20180230148
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to spiro-isoquinoline-4,4?-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 16, 2018
    Inventor: Carmen ALMANSA-ROSALES
  • 1,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10022359
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to 1,9-diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: July 17, 2018
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carlos Alegret-Molina, Carmen Almansa-Rosales
  • SPIRO-ISOQUINOLINE-3,4'-PIPERIDINE COMPOUNDS HAVING ACTIVITY AGAINST PAIN
    Publication number: 20180155343
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to spiro-isoquinoline-3,4?-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: April 27, 2016
    Publication date: June 7, 2018
    Inventor: Carmen ALMANSA-ROSALES
  • Piperidine derivatives having multimodal activity against pain
    Patent number: 9981942
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 29, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators
    Patent number: 9963453
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 8, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández, Carmen Almansa-Rosales
  • SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20180111935
    Abstract: The present invention relates to spiro-isoquinoline-1,4?-piperidine compounds having dual pharmacological activity towards both the sigma (?) receptor and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 20, 2015
    Publication date: April 26, 2018
    Inventors: Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ, Ana-Maria CAAMANO-MOURE
  • Piperidine compounds having multimodal activity against pain
    Patent number: 9902711
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: February 27, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez, Eva Maria Ayet Galcera, Maria Teresa Serafini Cabanes
  • 1-METHYLPYRAZOLE-PIPERAZINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170362215
    Abstract: The present invention relates to 1-methylpyrazole-piperazine compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 15, 2015
    Publication date: December 21, 2017
    Inventors: Carmen ALMANSA-ROSALES, Monica GARCIA-LOPEZ, Lourdes GARRIGA-SANAHUJA
  • 1,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170354648
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to 1,9-diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 20, 2015
    Publication date: December 14, 2017
    Applicant: Laboratorios del Dr. Esteve, S.A.
    Inventors: Marina VIRGILI-BERNADO, Carlos ALEGRET-MOLINA, Carmen ALMANSA-ROSALES
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Publication number: 20170313723
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 2, 2015
    Publication date: November 2, 2017
    Applicant: Laboratorios del Dr. Esteve, S.A.
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carlos ALEGRET-MOLINA, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ
  • METHYL-1H-PYRAZOLE ALKYLAMINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170305862
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to methyl-1 H-pyrazole alkylamine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 15, 2015
    Publication date: October 26, 2017
    Inventors: Antoni TORRENS-JOVER, Josep MAS-PRIO, Carmen ALMANSA-ROSALES, Monica GARCIA-LOPEZ
  • AMIDE DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170197984
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. wherein Y is n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, —C(O)O—, —C(O)NR8—, —C(O)—, —O— or —C(R4R4?)—; R1 is C(O)R5 or S(O)2R5.
    Type: Application
    Filed: June 2, 2015
    Publication date: July 13, 2017
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carlos ALEGRET-MOLINA, Carmen ALMANSA-ROSALES, Ramón MERCE-VIDAL
  • Fused imidazolyl derivatives, their preparation and use as medicaments
    Patent number: 9676784
    Abstract: The present invention relates to new fused imidazolyl derivatives having a high affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 13, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Díaz-Fernández, Carmen Almansa-Rosales, Piotr Nieczypor
  • ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170101420
    Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 13, 2017
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carlos ALEGRET-MOLINA, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ
  • 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
    Patent number: 9611229
    Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: April 4, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Antoni Torrens-Jover, Ute Christmann, Josè-Luis Diaz-Fernández, Carmen Almansa-Rosales
  • Pyrazolo[3,4-]pyrimidine compounds, their preparation and use as sigma ligands
    Patent number: 9567338
    Abstract: Pyrazolo[3,4-d]pyrimidine compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as a process for preparing these compounds, compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 14, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Maria Rosa Cuberes-Altisent, Jordi Corbera-Arjona, Jose Luis Diaz-Fernandez, Carmen Almansa-Rosales
  • Piperidine compounds having multimodal activity against pain
    Publication number: 20170001979
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 19, 2014
    Publication date: January 5, 2017
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ, Eva Maria AYET GALCERA, María Teresa SERAFINI CABANES
  • PIPERAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170001967
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 19, 2014
    Publication date: January 5, 2017
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ