Patents by Inventor Carmen Almansa Rosales

Carmen Almansa Rosales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine derivatives having multimodal activity against pain
    Patent number: 10745361
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 18, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia-Lopez
  • Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10703765
    Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: July 7, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • NEW PROPANAMINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200207759
    Abstract: The present invention relates to new compounds of general formula (I) that show dual activity towards ?2? subunit of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit, and to the noradrenallne transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: July 27, 2018
    Publication date: July 2, 2020
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Monica ALONSO-XALMA, Laura OSORIO-PLANES
  • (HETERO)ARYLALKYLAMINO-PYRAZOLOPYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200199127
    Abstract: The present invention relates to (hetero)arylalkylamino-pyrazolopyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the Noradrenaline transporter (NET), to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 29, 2018
    Publication date: June 25, 2020
    Inventors: Susana YENES-MINGUEZ, Ariadna FERNANDEZ-DONIS, Carmen ALMANSA-ROSALES
  • OXA-Diazaspiro compounds having activity against pain
    Patent number: 10689398
    Abstract: The present invention relates to oxa-diazaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 23, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
  • 2-PHENYL-2H-PYRAZOLO[3,4-D]PYRIDAZINE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20200190087
    Abstract: The present invention relates to 2-phenyl-2H-pyrazolo[3,4-d]pyridazine derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 18, 2020
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES
  • META SUBSTITUTED PHENYLPYRAZOLO- AND PHENYLPYRROLO- PYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200190081
    Abstract: The present invention relates to meta substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the NET receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 18, 2020
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carmen ALMANSA-ROSALES, José-Luis DÍAZ-FERNÁNDEZ
  • 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-Yl)methoxy)ethyl)piperazin-1- Yl)ethanone salts
    Patent number: 10640468
    Abstract: The present invention relates to 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethy)piperazin-1-y)ethanone salts, specifically to the hydrochloride and to the maleate, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor associated diseases.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: May 5, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Antoni Torrens-Jover, Carmen Almansa-Rosales
  • COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200123115
    Abstract: The present invention relates to a compound of formula (I): wherein the meanings for the various substituents are as disclosed in the description, having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the NET receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 25, 2018
    Publication date: April 23, 2020
    Inventors: Susana YENES-MINGUEZ, Carmen ALMANSA-ROSALES
  • NEW QUINOLINE AND ISOQUINOLINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200087291
    Abstract: The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).
    Type: Application
    Filed: December 20, 2017
    Publication date: March 19, 2020
    Inventors: Carmen ALMANSA-ROSALES, Susana YENES-MÍNGUEZ, Marina VIRGILI-BERNADO, Monica ALONSO-XALMA
  • Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions
    Patent number: 10590140
    Abstract: The present invention relates to new compounds of general formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels, and noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: March 17, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales
  • Arylamide derivatives having multimodal activity against pain
    Patent number: 10577360
    Abstract: The present invention relates to arylamide derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: March 3, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Pilar Goya, Antoni Torrens-Jover, Carmen Almansa-Rosales, Jose-Luis Diaz-Fernández, Ana-Maria Caamaño-Moure
  • SUBSTITUTED PYRROLIDINYL AND PIPERIDINYL PYRAZOLOPYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200062767
    Abstract: The present invention relates to substituted pyrrolidinyl and piperidinyl pyrazolopyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2??1 subunit, of the voltage-gated calcium channel and the Noradrenaline transporter (NET), to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 29, 2018
    Publication date: February 27, 2020
    Inventors: Carmen ALMANSA-ROSALES, José-Luís DÍAZ-FERNÁNDEZ, Ariadna FERNANDEZ-DONIS, Susana YENES-MINGUEZ
  • Ortho substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having multimodal activity against pain
    Patent number: 10562908
    Abstract: The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: February 18, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carmen Almansa-Rosales
  • TETRAHYDROPYRAN AND TETRAHYDROTHIOPYRAN AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200010457
    Abstract: The present invention relates to tetrahydropyran and tetrahydrothiopyran amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 15, 2017
    Publication date: January 9, 2020
    Inventors: Monica GARCIA-LOPEZ, Carmen ALMANSA-ROSALES
  • PYRAZOLE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20200002283
    Abstract: The present invention relates to pyrazole derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 26, 2017
    Publication date: January 2, 2020
    Inventors: Carmen ALMANSA-ROSALES, Susana YENES-MÍNGUEZ, José-Luis DÍAZ-FERNÁNDEZ, Antonio David RODRIGUEZ-GARRIDO
  • Spiro-isoquinoline-4,4?-piperidine compounds having multimodal activity against pain
    Patent number: 10508114
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to spiro-isoquinoline-4,4?-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: December 17, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventor: Carmen Almansa-Rosales
  • NITROGEN CONTAINING BICYCLIC DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20190345146
    Abstract: The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).
    Type: Application
    Filed: December 20, 2017
    Publication date: November 14, 2019
    Inventors: Carmen ALMANSA-ROSALES, Marina VIRGILI-BERNADO, Monica ALONSO-XALMA
  • Substituted amide derivatives having multimodal activity against pain
    Patent number: 10428051
    Abstract: The present invention relates to substituted amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: October 1, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales, Ana Virginia Llorente-Fernandez, Lourdes Garriga-Sanahuja, Ute Christmann
  • ORTHO SUBSTITUTED PHENYLPYRAZOLO- AND PHENYLPYRROLO-PYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190284195
    Abstract: The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: September 19, 2019
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carmen ALMANSA-ROSALES